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Intracranial Haemorrhage in Patients Treated with Monoamineoxidase Inhibitors

Published online by Cambridge University Press:  29 January 2018

J. C. de Villiers*
Affiliation:
Atkinson Morley's Hospital, Wimbledon, London, S.W.20

Extract

The monoamineoxidase inhibitor drugs are now widely used in the treatment of depression, and complications occurring in patients so treated have been reported with varying frequency. The drugs most frequently implicated have been tranylcypromine (Parnate), tranylcypromine plus trifluoperazine (Parstelin) and phenelzine (Nardil) in decreasing order of frequency. These complications may be divided into three symptom-complexes which may merge one into the other, as they have the common basis of rapid elevation of systemic blood pressure.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1966 

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References

Asatoor, A. M., Levi, A. J., and Milne, M. D. (1963). “Tranylcypromine and cheese.” Lancet, ii, 733734.CrossRefGoogle Scholar
Arenillas, L. (1963). “Tranylcypromine.” Ibid., ii, 586.Google Scholar
Ayd, , Arenillas, L. Quoted by Mann and Laing.Google Scholar
Bass, B. H. (1961). “Side effects of tranylcypromine.” Lancet, ii, 1099.CrossRefGoogle Scholar
Bethune, H. C., Burrell, R. H., and Culpan, R. H. (1963). “Headache associated with monoamine oxidase inhibitors.” Ibid., ii, 12331234.Google Scholar
Blackwell, B. (1963). “Hypertensive crises due to monoamine oxidase inhibitors.” Ibid., ii, 849851; and Correspondence i, 167, ii, 414.Google Scholar
Blackwell, B. and Marley, E. (1964). “Interaction between cheese and monoamine-oxidase inhibitors in rats and cats.” Ibid., i, 530531.Google Scholar
Bram, G. (1963). “Side-effects of tranylcypromine.” Brit. med. J. ii, 1407.Google Scholar
Brown, D. D., and Waldron, D. H. (1962). “An unusual reaction to tranylcypromine.” Practitioner, 189, 8386.Google Scholar
Burke, C. W. (1963). “Collapse after Parstelin.” Brit. med. J., ii, 998999.Google Scholar
Clark, J. A. (1961). “Side-effects of tranylcypromine.” Lancet, i, 618619.CrossRefGoogle Scholar
Cooper, A. J., Magnus, R. V., and Rose, M. J. (1964). “A hypertensive syndrome with tranylcypromine medication.” Ibid., i, 527529.Google Scholar
Cuthill, J. M., Griffiths, A. B., and Powell, D. E. (1964). “Death associated with tranylcypromine and cheese.” Ibid., i, 1076–77.Google Scholar
Dally, P. J. (1962). “Fatal reaction associated with tranylcypromine and methylamphetamine.” Ibid., i, 12351236.Google Scholar
Davies, E. B. (1963a). “Tranylcypromine and cheese.” Ibid., ii, 691692.Google Scholar
Davies, E. B. (1963b). “Combining the antidepressant drugs.” Ibid., ii, 781782.Google Scholar
Denton, P. H., Borrelli, V. M., and Edwards, H. V. (1962). “Dangers of monoamineoxidase inhibitors.” Brit. Med. J., ii, 1752.CrossRefGoogle Scholar
Dorrell, W. (1963a). “Tranylcypromine.” Lancet, i, 388.Google Scholar
Dorrell, W. (1963b). “Tranylcypromine and intracranial bleeding.” Ibid., ii, 300.Google Scholar
Enoch, M. D. (1963). “Tranylcypromine.” Ibid., ii, 464465.Google Scholar
Espir, M. L. E., and Mitchell, L. (1963). “Tranylcypromine and intracranial hemorrhage.” Ibid., ii, 639.Google Scholar
Foster, A. R. (1963). “Tranylcypromine and cheese.” Ibid., ii, 587.Google Scholar
Garmany, G. (1964). “Monoamine-oxidase inhibitors.” Ibid., i, 932.Google Scholar
Glazener, F. S., Morgan, A., Simpson, J. M., and Johnson, P. K. (1964). “Pargyline, cheese and acute hypertension.” J. Amer. Med. Assoc., 188, 754755.Google Scholar
Greene, D. (1963). “Tranylcypromine.” Lancet, ii, 586.Google Scholar
Hodge, J. V., and Nye, E. R. (1964). “Hypertensive crises after eating broad beans in patients treated with monoamine-oxidase inhibitor.” Proc. Univ. Otago Med. Sch., 42, 910.Google Scholar
Horwitz, D., Lovenberg, W., Engelman, K., and Sjoerdsma, A. (1964). “Monoamine oxidase inhibitors, tyramine and cheese.” J. Amer. Med. Assoc., 188, 11081110.Google Scholar
Lees, C. W., and Burke, , Sjoerdsma, A. (1963). “Tranylcypromine.” Lancet, i, 1316.Google Scholar
Low-Beer, G. A., and Tidmarsh, D. (1963). “Collapse after Parstelin.” Brit. med. J., ii, 683684.CrossRefGoogle Scholar
Luby, E. D., and Domino, E. F. (1961). “Toxicity from large doses of imipramine and MAO inhibitor in suicidal intent.” J. Amer. Med. Assoc., 177, 6869.Google Scholar
Lurie, M. L., and Salzer, M. M. (1961). “Tranylcypromine (Parnate) in the ambulatory treatment of depressed patients.” Amer. J. Psychiat., 118, 152155.Google Scholar
MacDonald, R. (1963). “Tranylcypromine.” Lancet, i, 269.Google Scholar
Mann, A. M., and Laing, W. A. R. (1963). “Tranylcypromine cephalalgia.” Canad. Med. Assoc. J., 89, 11151118.Google Scholar
Mason, A. (1962). “Fatal reaction associated with tranylcypromine and methylamphetamine.” Lancet, i, 1073.Google Scholar
McLure, J. L. (1962). “Reactions associated with tranylcypromine,Ibid., i, 1351.Google Scholar
Mendels, J. (1964). “The cheese reaction.” Ibid., i, 762763.Google Scholar
Milligan, L. W. (1963). “Tranylcypromine.” Ibid., i, 442.Google Scholar
Morgan, D. H. (1963). “Tranylcypromine.” Ibid., i, 389.Google Scholar
Natoff, I. L. (1964). “Cheese and monoamine-oxidase inhibitors.” Ibid., i, 532533.Google Scholar
Resnick, O. (1959). “The influence of amine oxidase inhibitors on epinephrine metabolism in man.” Ann. N.Y. Acad. Sci., 80, 726733.Google Scholar
Richardson, A. E. (1964). Personal communication.Google Scholar
Richmond, P. W., and Roberts, A. M. (1963). “Side effects of tranylcypromine.” Brit. med. J., ii, 999.CrossRefGoogle Scholar
Sargant, W. (1963). “Combining the antidepressant drugs.” Lancet, ii, 634635.Google Scholar
Schrire, I. (1963). “Collapse after Parstelin.” Brit. med. J., ii, 748.Google Scholar
Schrire, I. (1964). Quoted in leading article. Ibid., i, 578579.Google Scholar
Taylor, D. C. (1962). “Alarming reactions to pethidine in patients on phenelzine. Lancet, ii, 401.Google Scholar
Thomas, J. C. S. (1963). “Monoamine-oxidase inhibitors and cheese.” Brit. med. J., ii, 1606.Google Scholar
Warner, R. R. P. (1964) “Monoamine-oxidase inhibitors.” Lancet, i, 932.Google Scholar
Watts, C. A. H. (1964). “Antidepressant drugs.” Brit. med., J., i, 932.Google Scholar
Weber, J. C. P. (1964). Personal communication.Google Scholar
Womack, A. M. 1963. “Tranylcypromine,Brit. med. J., ii, 366.Google Scholar
Zeck, P. (1961). “The dangers of some antidepressant drugs.” Med. J. Australia, ii, 607608.Google Scholar
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