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Inhibition of In Vitro Production of Aldosterone by Manic-Depressive Sera

Published online by Cambridge University Press:  29 January 2018

R. P. Hullin ,
M. J. Levell ,
M. J. O'Brien  and
K. J. Toumba
R. P. Hullin
Affiliation:
Leeds Area Health Authority (Teaching), Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, West Yorkshire, LS29 6AQ
M. J. Levell
Affiliation:
Department of Chemical Pathology, Leeds Area Health Authority (Teaching), Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, West Yorkshire, LS29 6AQ
M. J. O'Brien
Affiliation:
Department of Biochemistry, Leeds Area Health Authority (Teaching), Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, West Yorkshire, LS29 6AQ
K. J. Toumba
Affiliation:
Department of Biochemistry, Leeds Area Health Authority (Teaching), Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, West Yorkshire, LS29 6AQ
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Summary

Serum samples from psychiatric patients were added to incubations of rat adrenal cortical cells synthesizing aldosterone. A high proportion of sera from patients with bipolar manic-depressive psychosis inhibited aldosterone production, but chronic in-patients without affective disorders gave few inhibitory sera. Inhibition was greatest in depression, lowest during normal affect. In one patient studied through 11 affective cycles the inhibitor score increased during transitions from mania to depression, showing a significant regression on time. The possible relationship of this in vitro phenomenon to the defect of aldosterone regulation in manic-depressive psychosis is discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 138 , Issue 5 , May 1981 , pp. 373 - 380
Copyright
Copyright © Royal College of Psychiatrists, 1981 

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