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The Importance of Dosage in Prescribing Antidepressants

Published online by Cambridge University Press:  29 January 2018

Frederick M. Quitkin
Frederick M. Quitkin*
Affiliation:
Department of Psychiatry, College of Physicians and Surgeons, Columbia University; and New York Psychiatric Institute, 722 West 168th Street, New York, New York 10032, USA
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Extract

The treatment of depressive disorders was significantly altered by the introduction of the tricyclic antidepressants and the monoamine oxidase inhibitors. One salient factor in determining efficacy is the dose prescribed. The few good dose response studies which are available indicate that patients should receive 300 mg of imipramine or equivalent, and a separate trial of 90 mg of phenelzine or equivalent, before concluding they are treatment refractory. Data are reviewed which suggest many patients receive inadequate doses.

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Annotation
Information
The British Journal of Psychiatry , Volume 147 , Issue 6 , December 1985 , pp. 593 - 597
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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