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ICI 204, 636: A New Atypical Antipsychotic Drug

Published online by Cambridge University Press:  06 August 2018

Steven R. Hirsch ,
Christopher G. G. Link ,
Jeffrey M. Goldstein  and
Lisa A. Arvanitis
Steven R. Hirsch*
Affiliation:
Charing Cross and Westminster Medical School, London
Christopher G. G. Link
Affiliation:
Zeneca Pharmaceuticals, Mereside
Jeffrey M. Goldstein
Affiliation:
CNS Clinical Research, Zeneca Pharmaceuticals, Wilmington, Delaware, USA
Lisa A. Arvanitis
Affiliation:
CNS Clinical Research, Zeneca Pharmaceuticals, Wilmington, Delaware, USA
*
Professor Steven R. Hirsch, Department of Psychiatry, Charing Cross and Westminster Medical School, London W6 8RP
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Extract

The therapeutic effects of ‘classic’ (typical) antipsychotic agents lie in their ability to block central dopaminergic receptors – a property that is also responsible for the frequent occurrence of undesirable extrapyramidal side-effects (EPS). In contrast to these typical agents, clozapine alone has distinguished itself in humans – by virtue of its enhanced antipsychotic action and lack of concurrent EPS – as an atypical antipsychotic. However, the use of clozapine has been limited by the occurrence of agranulocytosis and, to a lesser extent, seizures (Alvir et al, 1993; Haring et al, 1994). The mechanism underpinning the atypical profile of clozapine remains elusive. One hypothesis suggests that it lies in clozapine's higher serotonin 5-HT2: D2 binding ratio, when compared with typical agents – a factor being considered as a predictor of atypicality (Meltzer, this issue; Meltzer et al, 1989). However, an emerging view is that it is not a single pharmacological action, but rather multiple properties that may define an atypical, clozapine-like compound (Lieberman, 1993).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 168 , Issue S29: Current Issues in the Development of Atypical Antipsychotic Drugs , May 1996 , pp. 45 - 56
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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