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Hypertensive Interactions Between Monoamine Oxidase Inhibitors and Foodstuffs

Published online by Cambridge University Press:  29 January 2018

B. Blackwell ,
E. Marley ,
J. Price  and
D. Taylor
B. Blackwell
Affiliation:
The Maudsley Hospital
E. Marley
Affiliation:
Institute of Psychiatry
J. Price
Affiliation:
M.R.C. Psychiatric Genetics Research Unit, Institute of Psychiatry
D. Taylor
Affiliation:
Guys-Maudsley Neurosurgical Unit London, S.E.5
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Extract

Hypertensive attacks during treatment with amine oxidase inhibitors were first described in tuberculous patients, and were “rediscovered'’ when these drugs were introduced into psychiatry. In an assessment of iproniazid for tuberculosis (Ogilvie, 1955), 4 out of 42 patients experienced “attacks of a most distressing nature”, with severe throbbing occipital headache and high blood pressure. Six years later, similar attacks were observed in 5 out of 212 patients treated for depression with nialamide (Davies, 1959), but it was not until the introduction of tranylcypromine that reports again appeared (Lurie and Salzer, 1961; Clark, 1961). By the beginning of 1963, over 40 such cases had been reported, including several complicated by intracerebral haemorrhage or cardiac failure due to the rise in blood pressure (Songco, 1961; McClure, 1962; Dorrell, 1963).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 113 , Issue 497 , April 1967 , pp. 349 - 365
Copyright
Copyright © Royal College of Psychiatrists, 1967 

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