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High-Dose Propranolol in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Graham P. Sheppard
Graham P. Sheppard*
Affiliation:
Warley Hospital, Essex
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Summary

Eight male schizophrenics were treated in an open study with d.l. propranolol. The dose was increased by 160 mg/day until a maximum of 2,400 mg/day was achieved on day 15, and this remained constant until day 21. Seven patients showed significant clinical evidence of psychiatric improvement, while the incidence of toxic side-effects was low. There was wide inter-patient variation in plasma levels of propranolol. Despite a significant increase of plasma propranolol between day 15 and day 21 of the study, there was no significant change in serum prolactin.

Type
Papers
Information
The British Journal of Psychiatry , Volume 134 , Issue 5 , May 1979 , pp. 470 - 476
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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