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Head Circumference in ‘Preschizophrenic’ and Control Neonates

Published online by Cambridge University Press:  02 January 2018

Thomas F. McNeil ,
Elizabeth Cantor-Graae ,
Lars G. Nordström  and
Thomas Rosenlund
Thomas F. McNeil*
Affiliation:
University of Lund Department of Psychiatry, Malmö General Hospital, S-214 01, Malmö, Sweden
Elizabeth Cantor-Graae
Affiliation:
University of Lund Department of Psychiatry, Malmö General Hospital, S-214 01, Malmö, Sweden
Lars G. Nordström
Affiliation:
University of Lund Department of Psychiatry, Malmö General Hospital, S-214 01, Malmö, Sweden
Thomas Rosenlund
Affiliation:
University of Lund Department of Psychiatry, Malmö General Hospital, S-214 01, Malmö, Sweden
*
∗Correspondence
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Abstract

Head circumference, body weight, body length, and shoulder circumference at birth were studied in 70 RDC schizophrenic patients and 70 demographically matched controls from the same delivery series, using information recorded in the medical records at the time of birth. With preterm babies removed from both samples, only head circumference among preschizophrenic infants was significantly smaller than that of controls. Preschizophrenic infants also had a disproportionately smaller head circumference in relation to body length than did controls. Among the former, a small head circumference was systematically related to an absence of family history of psychosis, but was not related to season of birth or recorded pregnancy complications. The findings were strongest for females. The results suggest there is an unidentified non-genetic factor in schizophrenia that disturbs prenatal cerebral development.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 162 , Issue 4 , April 1993 , pp. 517 - 523
Copyright
Copyright © Royal College of Psychiatrists, 1993 

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References

Andreasen, N. C., Nasrallah, H. A., Dunn, V. et al (1986) Structural abnormalities in the frontal system in schizophrenia: a magnetic resonance imaging study. Archives of General Psychiatry, 43, 136–144.Google Scholar
Andreasen, N. C., Ehrhardt, J. C., Crossett, J. H., et al (1987) Hat size in schizophrenia. Archives of General Psychiatry, 44, 674–676.Google Scholar
Andreasen, N. C., Swayze, V., Flaum, M., et al (1990) Ventricular enlargement in schizophrenia evaluated with computed tomographic scanning. Archives of General Psychiatry, 47, 1008–1015.Google Scholar
Baum, J. D. & Searls, D. (1971) Head shape and size of pre–term low-birthweight infants. Developmental Medicine and Child Neurology, 13, 576–581.Google Scholar
Bogerts, B., Meertz, E. & Schönfeldt–Bausch, R. (1985) Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage. Archives of General Psychiatry, 42, 784–791.CrossRefGoogle ScholarPubMed
Bruton, C. J., Crow, T. J., Frith, C. D., et al (1990) Schizophrenia and the brain: a prospective clinico–neuropathological study. Psychological Medicine, 20, 285–304.CrossRefGoogle Scholar
Casanova, M. F., Daniel, D. G., Goldberg, T. E., et al (1989) Shape analysis of the middle cranial fossa of schizophrenic patients. A computerized tomographic study. Schizophrenia Research, 2, 333–338.Google Scholar
Coffey, V. P. & Jessop, W. J. E. (1959) Maternal influenza and congenital deformities: a prospective study. Lancet, ii, 935–938.Google Scholar
Daniel, D. G., Myslobodsky, M. S., Ingraham, L. J., et al (1989) The relationship of occipital skull asymmetry to brain parenchymal measures in schizophrenia. Schizophrenia Research, 2, 465–472.Google Scholar
DeLisi, L. E. & Goldin, L. R. (1987) Hat size in schizophrenia. Archives of General Psychiatry, 44, 672–673.Google Scholar
DeLisi, L. E., Dauphinais, I. D. & Gershon, E. S. (1988) Perinatal complications and reduced size of brain limbic structures in familial schizophrenia. Schizophrenia Bulletin, 14, 185–191.Google Scholar
Falkai, P. & Bogerts, B. (1986) Cell loss in the hippocampus of schizophrenics. European Archives of Psychiatric Neurological Science, 263, 154–161.CrossRefGoogle Scholar
Finnström, O. (1971a) Studies on maturity in newborn infants. I. Birth weight, crown–heel length, head circumference and skull diameters in relation to gestational age. Acta Paediatrica Scandinavica, 60, 685–694.Google Scholar
Finnström, O. (1971b) Studies on maturity in newborn infants. III. Neurological examination. Neuropädiatrie, 3, 72–96.Google Scholar
Gamstorp, I. (1970) Paediatric Neurology. London: Butterworths.Google Scholar
Green, M. F., Satz, P., Gaier, D. J., et al (1989) Minor physical anomalies in schizophrenia. Schizophrenia Bulletin, 15, 91–99.Google Scholar
Hays, W. L. (1963) Statistics for Psychologists. New York: Holt, Rinehart and Winston.Google Scholar
Illowsky, B., Juliano, D. M., Bigelow, L. B., et al (1988) Stability of CT scan findings in schizophrenia: results of an 8 year follow–up study. Journal of Neurology, Neurosurgery and Psychiatry, 51, 209–213.Google Scholar
Jakob, H. & Beckmann, H. (1986) Prenatal developmental disturbances in the limbic allocortex in schizophrenics. Journal of Neural Transmissions, 65, 303–326.Google Scholar
Jernigan, T. L., Zisook, S., Heaton, R. K., et al (1991) Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Archives of General Psychiatry, 48, 881–890.Google Scholar
Jones, G. H. & Lewis, J. E. (1991) Head circumference in elderly long–stay patients with schizophrenia. British Journal of Psychiatry, 159, 435–438.Google Scholar
Kendell, R. E. & Kemp, I. W. (1989) Maternal influenza in the etiology of schizophrenia. Archives of General Psychiatry, 46, 878–882.Google Scholar
Kinney, D. K. & Jacobsen, B. (1978) Environmental factors in schizophrenia: new adoption study evidence. In The Nature of Schizophrenia: New Approaches to Research and Treatment (eds Wynne, L. C., Cromwell, R. L. & Matthysse, S.), pp. 38–51. New York: Wiley.Google Scholar
Klein, J. O., Remington, J. S. & Marcy, S. M. (1983) Current concepts of infections of the fetus and newborn infant. In Infections and Diseases of the Fetus and Newborn (eds Remington, J. S. & Klein, J. O.), pp. 9–26. Philadelphia: Saunders.Google Scholar
Kovelman, J. A. & Scheibel, A. B. (1984) A neurohistological correlate of schizophrenia. Biological Psychiatry, 19, 1601–1621.Google Scholar
Lewis, S. W. & Murray, R. M. (1987) Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia. Journal of Psychiatric Research, 21, 413–421.Google Scholar
Lewis, S. W., Reveley, A. M., Reveley, M. A., et al (1987) The familial/sporadic distinction as a strategy in schizophrenia research. British Journal of Psychiatry, 151, 306–313.Google Scholar
McGuffin, P., Farmer, A. & Gottesman, I. I. (1987) Is there really a split in schizophrenia? The genetic evidence. British Journal of Psychiatry, 150, 581–592.CrossRefGoogle ScholarPubMed
McMillen, M. M. (1979) Differential mortality by sex in fetal and neonatal deaths. Science, 204, 89–90.Google Scholar
McNeil, T. F. (1987) Perinatal influences in the development of schizophrenia. In Biological Perspectives of Schizophrenia (eds Helmchen, H. & Henn, F. A.), pp. 125–138. Chichester: Wiley.Google Scholar
Nellhaus, G. (1968) Head circumference from birth to eighteen years. Pediatrics, 41, 106–114.Google Scholar
Netter, F. H. (1983) CIBA Collection of Medical Illustrations. Vol. 1. Nervous System. Part II. Neurologic and Neuromuscular Disorders. West Caldwell, New Jersey: CIBA.Google Scholar
O'Callaghan, E., Gibson, T., Colohan, H. A., et al (1991a) Season of birth in schizophrenia. Evidence for confinement of an excess of winter births to patients without a family history of mental disorder. British Journal of Psychiatry, 158, 764–769.Google Scholar
O'Callaghan, E., Sham, P., Takei, N., et al (1991b) Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet, 337, 1248–1250.Google Scholar
Oxenstierna, G., Bergstrand, G., Bjerkenstedt, L., et al (1984) Evidence of disturbed CSF circulation and brain atrophy in cases of schizophrenic psychosis. British Journal of Psychiatry, 144, 654–661.Google Scholar
Pakkenberg, B. (1987) Post–mortem study of chronic schizophrenic brains. British Journal of Psychiatry, 151, 744–752.Google Scholar
Schwarzkopf, S. B., Nasrallah, H. A., Olson, S. C., et al (1989) Perinatal complications and genetic loading in schizophrenia: preliminary findings. Psychiatry Research, 27, 233–239.Google Scholar
Siegel, S. (1957) Nonparametric Statistics. New York: McGraw Hill.Google Scholar
Spitzer, R., Endioott, J. & Robins, E. (1978) Research Diagnostic Criteria rationale and reliability. Archives of General Psychiatry, 35, 773–782.Google Scholar
Volpe, J. J. (1987) Neurology of the Newborn. Philadelphia: W. B. Saunders.Google Scholar
Walker, E. & Emory, E. (1983) Infants at risk for psychopathology: offspring of schizophrenic parents. Child Development, 54, 1269–1285.Google Scholar
Zipursky, R. B. & Schulz, S. C. (1987) Seasonality of birth and CT findings in schizophrenia. Biological Psychiatry, 22, 1288–1292.Google Scholar
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