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Growth Hormone and other Responses to Clonidine in Patients with Endogenous Depression

Published online by Cambridge University Press:  29 January 2018

S. A. Checkley ,
A. P. Slade  and
E. Shur
S. A. Checkley
Affiliation:
Institute of Psychiatry, De Crespigny Park, London SE5 8AF; Honorary Consultant, Maudsley Hospital, London SE5 6AZ
A. P. Slade
Affiliation:
Institute of Psychiatry
E. Shur
Affiliation:
Institute of Psychiatry
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Summary

The growth hormone response to clonidine was significantly less in 10 drug-free patients with endogenous depression than in 10 normal subjects who were individually matched with the patients for age and sex. The hypotensive and sedative effects of clonidine in the two groups were similar. The findings may indicate a defect at central a adrenoceptors at least in neuroendocrine systems.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 138 , Issue 1 , January 1981 , pp. 51 - 55
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Audigier, Y. Virion, A. & Schwartz, J-C. (1976) Stimulation of cerebral histamine H2 receptors by clonidine. Nature, 262, 307–308.CrossRefGoogle ScholarPubMed
Blackard, W. G. & Heidingsfelder, S. A. (1968) Adrenergic receptor control mechanism for growth hormone secretion. Journal of Clinical Investigation, 47, 1407–1414.CrossRefGoogle ScholarPubMed
Bond, A. J. & Lader, M. H. (1974) The use of analogue scales in rating subjective feelings. British Journal of Medical Psychology, 47, 211–218.CrossRefGoogle Scholar
Borkowski, K. R. & Finch, L. (1979) A comparison of the cardiovascular effects of centrally administered clonidine and adrenaline in the anaesthetized rat. Journal of Pharmacy and Pharmacology, 31, 16–19.CrossRefGoogle ScholarPubMed
Buckler, J. H. M. Bold, A. M. Tabener, M. & London, D. R. (1969) Modification of normal responses to arginine by alpha-adrenergic blockade. British Medical Journal, iii, 153–154.CrossRefGoogle Scholar
Carney, M. W. P. Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry, 111, 659–674.Google Scholar
Casper, R. C. Davis, J. M. Pandey, G. N. Garver, D. L. & Dekirmenjian, H. (1977) Neuroendrocrine and amine studies in affective illness. Psychoneuroendocrinology, 2, 105–114.CrossRefGoogle Scholar
Cavero, I. & Roach, A. G. (1978) The effects of prazosin on the clonidine induced hypotension and bradycardia in rats and sedation in chicks. British Journal of Pharmacology, 62, 468–469.Google ScholarPubMed
Chan, S. H. H. & Koo, A. (1978) The participation of medullary reticular formation in clonidine-induced hypotension in rats. Neuropharmacology, 17, 367–373.CrossRefGoogle ScholarPubMed
Checkley, S. A. (1978) A new distinction between the euphoric and the antidepressant effects of methylamphetamine. British Journal of Psychiatry, 133, 416–423.CrossRefGoogle ScholarPubMed
Checkley, S. A. (1979) Corticosteroid and growth hormone responses to methylamphetamine in depressive illness. Psychological Medicine, 9, 107–116.Google Scholar
Checkley, S. A. (1980) Neuroendocrine studies of monoamine function in man: A review of basic theory and its application to the study of depressive illness. Psychological Medicine, 10, 35–53.CrossRefGoogle Scholar
Checkley, S. A. & Crammer, J. L. (1977) Hormonal responses to methylamphetamine in depression: A new approach to the noradrenaline depletion hypothesis. British Journal of Psychiatry, 131, 582–586.CrossRefGoogle Scholar
Delbarre, B. & Schmitt, H. (1971) Sedative effects of a sympathomimetic drugs and their antagonism by adrenergic and cholinergic blocking drugs. European Journal of Pharmacology, 13, 356–363.Google Scholar
Drew, G. M. Gower, A. J. & Marriott, A. S. (1979) α2 adrenoceptors mediate clonidine-induced sedation in rats. British Journal of Pharmacology, 67, 133–141.Google Scholar
Finch, L. Harvey, C. A. Hicks, P. E. & Owen, D. A. A. (1978) Clonidine-induced hypotension: Further evidence of a central interaction with histamine H2 receptor antagonists in the rat. Neuropharmacology, 17, 307–313.CrossRefGoogle ScholarPubMed
Frazer, A. (1975) Adrenergic responses in depression: implications for a receptor defect. In Biological Psychiatry (ed. Mendels, J.), pp 7–26. New York: John Wiley.Google Scholar
Ganong, W. F. Wise, B. L. Reid, I. A. Holland, J. Kaplan, S. Shackleford, R. & Boryczka, A. T. (1978) Effect of spinal cord transection on the endocrine and blood pressure responses to intravenous clonidine. Neuroendocrinology, 25, 105–110.CrossRefGoogle ScholarPubMed
Gold, M. S. Donabedian, R. K. & Redmond, D. E. (1978) Clonidine-induced increase in serum growth hormone: possible role of epinephrine-mediated synapses. Psychoneuroendocrinology, 3, 187–194.Google Scholar
Heidingsfelder, G. V. & Blackard, W. G. (1968) Adrenergic control mechanism of vasopressin-induced plasma growth hormone response. Metabolism, 17, 1019–1024.CrossRefGoogle ScholarPubMed
Imura, H. Nakai, Y. Kato, Y. Hoshimoto, Y. & Moridera, K. (1973) Effect of adrenergic drugs on growth hormone and ACTH secretion. In Endocrinology: Proceedings of the Fourth International Congress of Endocrinology (ed. Scow, R. O.), pp 156–162. New York: Excerpta Medica.Google Scholar
Karppanen, H. Paakkari, I. Paakkari, P. Huotari, R. & Orma, A-L. (1976) Possible involvement of central histamine H2 receptors in the hypotensive effect of clonidine. Nature, 259, 587–588.Google Scholar
Laakmann, G. & Benkert, O. (1978) Neuroendokrinologie und Psychopharmaka. Arzneimittel-Forschung/ Drug Research, 28, 1277–1280.Google Scholar
Lal, S. Tolis, G. Martin, J. B. Brown, G. M. & Guyda, H. (1975) Effect of clonidine on growth hormone, prolactin, luteinising hormone, follicle-stimulating hormone and thyroid stimulating hormone in the serum of normal men. Journal of Clinical Endocrinology and Metabolism, 41, 827–832.CrossRefGoogle ScholarPubMed
Lancranjan, I. & Marbach, P. (1977) New evidence for growth hormone modulation by the α-adrenergic system in Man. Metabolism, 26, 1225–1230.CrossRefGoogle ScholarPubMed
Langer, S. Z. (1977) Presypantic receptors and their role in the regulation of transmitter release. British Journal of Pharmacology, 60, 481–497.CrossRefGoogle ScholarPubMed
Maj, J. Baran, L. Sowinska, H. & Zielinski, M. (1975) The influence of cholinolytics on clonidine action. Polish Journal of Pharmacology and Pharmacy, 27. 17–26.Google ScholarPubMed
Matussek, N. (1978) Neuroendokrinologische Untersuchungen bei depressiven Syndromen. Der Nervenarzt 49, 569–575.Google Scholar
Nakai, Y. Imura, H. Yoshimi, T. & Matsukura, S. (1973) Adrenergic control mechanism for ACTH secretion in man. Acta Endocrinologica, 74, 263–270.Google ScholarPubMed
Pontiroli, A. E. Viberti, G. G. Vicari, A. & Pozza, G. (1976) Effect of antihistamine agents meclastine and dexchlorphreniramine on the response of human growth hormone to arginine infusion and insulin hypoglycaemia. Journal of Clinical Endocrinology and Metabolism, 43, 582–586.Google Scholar
Reid, J. L. Tangri, K. K. & Wing, L. M. H. (1977) The central hypotensive action of clonidine and propranolol in animals and man. Progress in Brain Research, 47, 369–384.Google Scholar
Rockhold, R. W. & Caldwell, R. W. (1979) Effect of lesions of the nucleus tractus solitarii on the cardiovascular actions of clonidine in conscious rats. Neuropharmacology, 18, 347–354.CrossRefGoogle ScholarPubMed
Sachar, E. J. Altman, N. Gruen, P. H. Glassman, A. Halpern, F. S. & Sassin, J. (1975) Human growth hormone response to L-DOPA in relation to menopause, depression and plasma level of L-DOPA. Archives of General Psychiatry, 3 2, 502–503.Google Scholar
Schmitt, H. Schmitt, H. & Fenard, S. (1971) Evidence for an a sympathomimetic component in the effects of catapresan on vasomotor centres: antagonism by piperoxane. European Journal of Pharmacology, 14, 98–100.CrossRefGoogle ScholarPubMed
Sharma, J. N. Sandrew, B. B. & Wang, S. C. (1978) CNS site of clonidine induced hypotension: a microiontophoretic study of bulbar cardiovascular neurons. Brain Research, 151, 127–133.Google Scholar
Spitzer, R. L. Endicott, J. & Robbins, E. (1977) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders. 3rd edition. New York State Psychiatric Institute, New York.Google Scholar
Tadepalli, A. S. & Mills, E. (1978) Contribution of supracollicular structures of the brain to the central depression of cardiovascular function by clonidine. The Journal of Pharmacology and Experimental Therapeutics, 205, 693–701.Google Scholar
Timmermans, P. B. Lam, E. & Van Zwieten, P. A. (1979) The interaction between prazosin and clonidine at a adrenoceptors in rats and cats. European Journal of Pharmacology, 55, 57–66.Google Scholar
Vogt, M. (1977) Histamine H2 receptors in the brain and sleep produced by clonidine. British Journal of Pharmacology, 61, 441–443.Google Scholar
Zandberg, P. De Jong, W. & De Wied, D. (1979) Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata. European Journal of Pharmacology, 55, 43–56.CrossRefGoogle ScholarPubMed
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