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A Genetic Model of Narcolepsy

Published online by Cambridge University Press:  29 January 2018

James F. Leckman  and
Elliot S. Gershon
James F. Leckman
Affiliation:
Unit on Clinical Psychogenetics, Adult Psychiatry Branch, National Institute of Mental Health, Bldg. 10, Rm. 3N218, 9000 Rockville Pike, Bethesda, Maryland 20014
Elliot S. Gershon
Affiliation:
Unit on Clinical Psychogenetics, Adult Psychiatry Branch, National Institute of Mental Health, Bldg. 10, Rm. 3N218, 9000 Rockville Pike, Bethesda, Maryland 20014
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Summary

An analysis of recently published family history data on rapid eye movement (REM) narcolepsy was undertaken to determine the goodness-of-fit of a multifactorial (MF) model of inheritance. The analysis revealed that a two-threshold MF model can successfully account for the prevalence of REM narcolepsy and other disorders of excessive sleep (DES) observed in the first-degree relatives of the REM narcoleptic probands studied.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 128 , Issue 3 , March 1976 , pp. 276 - 279
Copyright
Copyright © Royal College of Psychiatrists, 1976 

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