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Genetic Linkage in Mental Illness

Limitations and Prospects

Published online by Cambridge University Press:  02 January 2018

Miron Baron ,
Jean Endicott  and
Jurg Ott
Miron Baron*
Affiliation:
Columbia University College of Physicians & Surgeons, Director, Division of Psychogenetics, Department of Medical Genetics, New York State Psychiatric Institute
Jean Endicott
Affiliation:
Department of Research Assessment and Training
Jurg Ott
Affiliation:
Statistical Genetics Unit, Department of Medical Genetics
*
∗New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032, USA
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Abstract

Advances in genetic linkage strategies, including techniques of molecular genetics, augur well for the discovery of disease-related genes in mental disorders. Recent studies showing linkage of chromosomal loci to bipolar affective illness and schizophrenia attest to the potential in the ‘new genetics'. However, the failure to replicate some of the early findings has led to calls for re-evaluation of the methodology in psychiatric research. Problems in studying complex (psychiatric) disorders include diagnostic uncertainties, unclear mode of transmission, aetiological heterogeneity, cohort effects, and assortative mating. Knowing the potential pitfalls in linkage analysis of mental illness should avert spurious findings and will increase the prospects of success.

Type
Review Article
Information
The British Journal of Psychiatry , Volume 157 , Issue 5 , November 1990 , pp. 645 - 655
Copyright
Copyright © The Royal College of Psychiatrists 

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