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Fusarial Mycotoxins and Behaviour: Possible Implications for Psychiatric Disorder

Published online by Cambridge University Press:  29 January 2018

R. Schoental
R. Schoental*
Affiliation:
Affiliated to Department of Pathology, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU
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Summary

Man and animals are sporadically exposed to mycotoxins (the secondary metabolites of moulds), which include those produced in damp and cool environment by the almost ubiquitous soil-microfungi, the Fusaria. Perinatal exposure to the mycotoxins may cause damage to many organs, including the CNS and those which are targets for oestrogenic agents. Depending on the levels of the mycotoxins and the time of their action, the effects may manifest themselves as neonatal abnormalities, or as neurological and behavioural anomalies and chronic disorders later in life. The relationship between the anatomical and behavioural development of individuals and their perinatal exposure to fusarial mycotoxins requires further investigation.

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Information
The British Journal of Psychiatry , Volume 146 , Issue 2 , February 1985 , pp. 115 - 119
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

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References

Anon, (1979) Wernicke's encephalopathy. British Medical Journal. 3, 291–292.Google Scholar
Anon, (1983) Seasonality. Down's syndrome and anencephaly. Lancet. 1, 1312–1313.Google Scholar
Bamburg, J. R. & Strong, F. M. (1971) 12.13-cpoxytricholheccnes. In Microbial Toxins. A Comprehensive Treatise. Algal and Fungal Toxins (eds. Kadis, S., Ciegler, A. & Ajl, S. J.). Vol 7, London: Academic Press.Google Scholar
Boom, C. (1971) The genus Fusarium. Kew: Commonwealth Mycological Institute.Google Scholar
Chi, M. S., El-Halawani, M. E., Weibel, P. E. & Mirocha, C. J. (1981) Effects of T-2 toxin on brain catecholamines and selected blood components in growing chickens. Poultry Science. 60, 137–141.CrossRefGoogle ScholarPubMed
Gunn, J. (1975) Psychiatric aspects of violence and violent offenders. Forensic Science. 5, 219–227.Google Scholar
Haikara, A. (1983) Malt and beer from barley artificially contaminated with Fusarium in the field. European Brewing Convention Congress Proceedings, 401–408.Google Scholar
Hare, E. H. (1978) Variations in the seasonal distribution of births of psychotic patients in England and Wales. British Journal of Psychiatry, 132, 155–158.Google Scholar
Joffe, A. Z. (1978) Fusarium poae and F. sporotrichioides as principal causal agents of alimentary toxic aleukia. In Mycotoxic Fungi. Mycotocins. My cotoxicoses. An Encyclopedic Handbook (eds. Wyllie, T. D. & Morehouse, L. G.). New York: Marcel Dekker.Google Scholar
Jongbloei, P. H. (1970) Chromosomal aberrations and month of birth. Lancet. 2, 1317–1318.Google Scholar
Kholodenko, M. I. (1947) Changes in the nervous system in toxic alimentary aleukia (so-called “septic angina”). Nevropatologiia i Psykhiatriia. 16:4, 67–68.Google Scholar
Lamb, H. H. (1964) The English Climate. Calendar of Historic Weather Events since 1500, appendix 2. London: English University Press.Google Scholar
Laurence, K. M., Carter, C. O. & David, P. A. (1968) Major central nervous system malformations in South Wales. 1. Incidence, local variations and geographical factors. British Journal of Preventive & Social Medicine. 22, 146–160 and 212–222.Google Scholar
Lombroso, C. (1891) Man of Genius. London: Walter Scott.Google Scholar
Ludlum, D. M. (1971) Weather Record Book . The outstanding events 1871–1970. Princeton: Weatherwise Inc.Google Scholar
McKeown, T. & Record, R. G. (1951) Seasonal trends in congenital malformations of the central nervous system. Lancet, i, 192–196.Google Scholar
McNuti, S. R., Purwin, P. & Murray, C. (1928) Vulvovaginitis in swine. Preliminary report. Journal of the American Veterinary Medical Association. 73, 484–492.Google Scholar
Matsuoka, Y., Kubota, K. & Ueno, Y. (1979) General pharmacological studies of fusarcnon-X. a trichothecenc mycotoxin from Fusarium species. Toxicology & Applied Pharmacology. 50, 87–94.Google Scholar
Mayer, C. F. (1953) Endemic panmycolotoxicosis in the Russian grain belt. The Military Surgeon. 113, 173–189 and 295–315.Google Scholar
Mirocha, C. J., Pathre, S. V. & Christensen, C. M. (1977) Zearalenone. In Mycotoxins in Human and Animal Health (eds. Rodricks, J. V., Hesseltine, G. W. & Mehlman, M. A.) Park Forest South. Illinois: Pathotox Publications.Google Scholar
Nesterov, V. C. (1948) The clinical course of septic angina. Klinicheskaia Meditsina, 26:7, 34–41.Google Scholar
Payen, J., Girard, T., Gaillardin, M. & Lafont, P. (1983) About contamination of beers by mycotoxins. Microbiologie-Aliments-Nutrition. 1, 143–146.Google Scholar
Pulver, A. E., Sawyer, J. W. & Childs, B. (1981) The association between season of birth and the risk for schizophrenia. American Journal of Epidemiology, 114, 735–749.Google Scholar
Sáenz de Rodriguez, C. A. (1984) Environmental hormone contamination in Puerto Rico. New England Journal of Medicine. 310, 1741–1742.Google Scholar
Schneider, D. J., Marasas, W. F. O., Kuys, J. C. O., Kriek, N. P. J. & Schalkwyk, , van, G. C. (1979) A field outbreak of suspected stachybotryotoxicosis in sheep. Journal of the South African Veterinary Association, 50, 73–81.Google Scholar
Schoental, R. (1980) A corner of history. Moses and mycotoxins. Preventive Medicine. 9, 159–161.Google Scholar
Schoental, R. (1981a) Relationships of Fusarium toxins to tumours and other disorders in livestock. Journal of Veterinary Pharmacology and Therapeutics, 4, 1–6.Google Scholar
Schoental, R. (1981b) Carcinogenic mycotoxins. In Dietary Influences on Cancer, Traditional and Modem (eds. Schoental, R. & Connors, T. A.). Boca Raton: CRC Press.Google Scholar
Schoental, R. (1981c) Carcinogenic contaminants of food, ibid. Google Scholar
Schoental, R. (1982) Behavioural and other effects of secondary metabolites of certain Fusarium species. In Behavioral Models and the Analysis of Drug Action (eds. Spiegelstein, M. Y. & Levy, A.) Amsterdam: Elsevier.Google Scholar
Schoental, R. (1983a) Mozart's illnesses and death. Journal of the Royal Society of Medicine , 76, 1079, and idem. (1984a) ibid., 77, 157.Google Scholar
Schoental, R. (1983b) Health hazards of secondary metabolites of Fusarium. Microbiologie-Aliments-Nutrition, 1, 101–107.Google Scholar
Schoental, R. (1984) Mycotoxins and the Bible. Perspectives in Biology, 28, in press.Google Scholar
Schoental, R., Joffe, A. Z. & Yagen, B. (1979) Cardiovascular lesions and various tumours found in rats given T-2 toxin, a trichothecene metabolite of Fusarium species. Cancer Research, 39, 2179–2189.Google Scholar
Serafimov, B. N. (1946) Psychiatric symptomatology in alimentary toxic aleukia (septic angina). Nevropatologiia i Psykhiatriia, 15:6, 50–54.Google Scholar
Soulaiuac, M.-L. & Soulairac, A. (1974) Consequences de l'oestrogenisation post-natale sur le comportement sexuel et le tractus génital du rat mâle adulte. Journal de Physiologie, Paris, 68, 19B–20B.Google Scholar
Stob, M., Baldwin, R. S., Tuite, J., Andrews, F. N. & Gillette, K. G. (1962) Isolation of an anabolic, uterotropic compound from com infected with Gibberella zeae. Nature, 196, 1318.Google Scholar
Ueno, Y. (1980) Trichothecene mycotoxins. Mycology, chemistry and toxicology. Advances in Nutrition Research, 3, 301–353.Google Scholar
Utian, W. H. (1973) Comparative trial of P. 1496, a new non-steroidal oestrogen. British Medical Journal, i, 579–581.Google Scholar
Vannier, B. & Raynaud, J. P. (1980) Long-term effects of prenatal oestrogen treatment on genital morphology and reproductive function in the rat. Journal of Reproduction and Fertility, 59, 43–49.Google Scholar
Wilson, B. J., Maronpot, R. R. & Hildebrandt, P. K. (1973) Equine leukoencephalomalacia. Journal of the American Veterinary Medical Association, 163, 1293–5.Google Scholar
Wyatt, R. D., Colwell, W. M., Hamilton, P. B. & Burmeister, H. R. (1973) Neural disturbances in chickens caused by dietary T-2 toxin. Applied Microbiology, 26, 757–761.Google Scholar
Yagen, B., Joffe, A. Z., Horn, P., Mor, N. & Lutsky, I. I. (1977) Toxins from a strain involved in ATA. In Mycotoxins in Human and Animal Health (eds. Rod ricks, J. V., Hesseltine, G. W. & Mehlman, M. A. Forest Park South, Illinois, Pathotox Publications.Google Scholar
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