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The Finnish Adoptive Family Study of Schizophrenia

Implications for Family Research

Published online by Cambridge University Press:  06 August 2018

Pekka Tienari ,
Lyman C. Wynne ,
Juha Moring ,
Ilpo Lahti ,
Mikko Naarala ,
Anneli Sorri ,
Karl-Erik Wahlberg ,
Outi Saarento ,
Markku Seitamaa  and
Merja Kaleva
...Show all authors
Pekka Tienari*
Affiliation:
University of Oulu
Lyman C. Wynne
Affiliation:
University of Rochester
Juha Moring
Affiliation:
University of Oulu
Ilpo Lahti
Affiliation:
University of Oulu
Mikko Naarala
Affiliation:
University of Oulu
Anneli Sorri
Affiliation:
University of Oulu
Karl-Erik Wahlberg
Affiliation:
University of Oulu
Outi Saarento
Affiliation:
University of Oulu
Markku Seitamaa
Affiliation:
University of Oulu
Merja Kaleva
Affiliation:
University of Oulu
Kristian Läksy
Affiliation:
University of Oulu
*
∗Department of Psychiatry, Kajaanintie 43, SF-90210 Oulu, Finland
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Abstract

A nationwide Finnish sample of schizophrenics' offspring given up for adoption was compared blindly with matched controls, who were adopted offspring of non-schizophrenic biological parents. The adoptive families were investigated thoroughly using joint and individual interviews and psychological tests. The biological parents were also interviewed and tested. Among the 155 index offspring, the percentage of both psychoses and other severe diagnoses (borderline syndrome and severe personality disorders) was significantly higher than in the 186 matched control adoptees. This supports a genetic hypothesis. However, notable differences between these two groups only emerged in the families which were rated as disturbed. Thus the genetic effect (i.e. the differences between high and low genetic propensity) was only manifested as a psychiatric disorder in the presence of a disturbed family environment. The impact of disturbed family relations was strongest in the presence of the appropriate genotype.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 164 , Issue S23: Integrated Approach to Schizophrenia , April 1994 , pp. 20 - 26
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn). Washington, DC: APA.Google Scholar
Asarnow, R. F. & Granholm, E. (1991) The contributions of cognitive psychology to vulnerability models. In Search for the Causes of Schizophrenia, Vol. II (eds Hairier, H. & Gattaz, W. F.), pp. 205–220. Berlin: Springer.Google Scholar
Fowles, D. C. (1992) Schizophrenia: diathesis–stress revisited. Annual Review of Psychology, 43, 303–336.Google Scholar
Goldfried, M. R., Stricker, G. & Weiner, I. B. (1971) Rorschach Handbook of Clinical and Research Applications. Englewood Cliffs, NJ: Prentice Hall.Google Scholar
Heston, L. L. (1966) Psychiatric disorders in foster home reared children of schizophrenic mothers. British Journal of Psychiatry, 112, 819–825.Google Scholar
Holzman, P. S. (1985) Eye movement dysfunction and psychosis. International Review of Neurobiology, 27, 179–205.Google Scholar
Johnston, M. H. & Holzman, P. S. (1979) Assessing Schizophrenic Thinking: a Clinical and Research Instrument for Measuring Thought Disorder. San Francisco: Jossey–Bass.Google Scholar
Kendler, K. S. & Eaves, L. J. (1986) Models for the joint effect of genotype and environment on liability to psychiatric illness. American Journal of Psychiatry, 143, 279–289.Google Scholar
Kety, S. S. (1988) Schizophrenic illness in the families of schizophrenic adoptees. Schizophrenia Bulletin, 14, 217–222.Google Scholar
Kringlen, E. (1991) Adoption studies in functional psychosis. European Archives of Psychiatry and Clinical Neurosciences, 240, 307–313.Google Scholar
Lidz, T., Blatt, S. & Cook, B. (1981) Critique of the Danish–American studies of the adopted-away offspring of schizophrenic parents. American Journal of Psychiatry, 138, 1063–1068.Google ScholarPubMed
Lidz, T., Blatt, S. & Cook, B. (1983) Critique of the Danish–American studies of the biological and adoptive relatives of adoptees who became schizophrenic. American Journal of Psychiatry, 140, 426–434.Google Scholar
Moring, J., Asarnow, K., Nuechterlein, K., et al (1991) Information processing impairment in Finnish adopted-away offspring of schizophrenic mothers and control mothers (abstract). Schizophrenia Research, 4, 282.CrossRefGoogle Scholar
Naarala, M., Moring, J., Sorri, A., et al (1988) Oulu Family Assessment Scale (OPAS) (abstract). IX International Symposium on the Psychotherapy of Schizophrenia, Turin, p. 181.Google Scholar
Nuechterlein, K. H. & Dawson, M. E. (1984) A heuristic vulnerability/stress model of schizophrenic episodes. Schizophrenia Bulletin, 10, 300–312.Google Scholar
Nuechterlein, K. H. & Dawson, M. E., Ventura, J., et al (1991) Testing vulnerability models: stability of potential vulnerability indicators across clinical state. In Search for the Causes of Schizophrenia. Vol. II (eds Häfner, H. & Gattaz, W. F.), pp. 177–191. Berlin: Springer.Google Scholar
Plomin, R., Defries, J. C. & Loehlin, J. C. (1977) Genotype–environment interaction and correlation in the analysis of human behavior. Psychological Bulletin, 84, 309–322.CrossRefGoogle ScholarPubMed
Pogue-Geile, M. F. & Rose, R. J. (1987) Psychopathology: a behavior genetic perspective. In Family Interaction and Psychopathology: Theories, Methods and Findings (ed. Jacob, T.), pp. 629–650. New York: Plenum Press.CrossRefGoogle Scholar
Rosenthal, D. (ed.) (1963) The Genain Quadruplets: a Case Study and Theoretical Analysis of Heredity and Environment in Schizophrenia. New York: Basic Books.Google Scholar
Rosenthal, D., Wender, P. H., Kety, S. S., et al (1971) The adopted-away offspring of schizophrenics. American Journal of Psychiatry, 128, 307–311.CrossRefGoogle ScholarPubMed
Scarr, S. & McCartney, K. (1983) How people make their own environments: a theory of genotype-environment effects. Child Development, 54, 424–435.Google Scholar
Shenton, M. E., Solovay, M. R. & Holzman, P. (1987) Comparative studies of thought disorders: II. Schizoaffective disorder. Archives of General Psychiatry, 44, 21–30.Google Scholar
Singer, M. T., Wynne, L. C. & Toohey, M. L. (1978) Communication disorders and the families of schizophrenics. In The Nature of Schizophrenia: New Approaches to Research and Treatment (eds Wynne, L. C., Cromwell, R. L. & Matthysse, S.), pp. 491–511. New York: Wiley.Google Scholar
Solovay, M. R., Shenton, M. E. & Holzman, P. S. (1987) Comparative studies of thought disorders: I. Mania and schizophrenia. Archives of General Psychiatry, 44, 13–20.Google Scholar
Soloway, M. E., Shenton, C., Gasparetti, M., et al (1986) Scoring manual for the Thought Disorder Index. Schizophrenia Bulletin, 12, 483–496.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry, 35, 773–782.Google Scholar
Tienari, P. (1991a) Genes, family environment or interaction: findings from an adoption study. In Etiology of Mental Disorder (eds Kringlen, E., Lavik, N. J. & Torgersen, S.), pp. 33–48. Oslo: Department of Psychiatry, Vindern, University of Oslo.Google Scholar
Tienari, P. (1991b) Cross-fostering: a research strategy for clarifying the role of genetic and experiential factors in the etiology of schizophrenia. In Psychiatry at the Crossroads Between Social Science and Biology in Psychiatry at the Crossroads Between Social Science and Biology (eds Torgersen, S., Abrahamsen, P. & Sorensen, T.), pp. 122–133. Oslo: Norwegian University Press.Google Scholar
Tienari, P. (1991c) Interaction between genetic vulnerability and family environment: the Finnish adoptive family study of schizophrenia. Acta Psychiatrica Scandinavica, 84, 460–465.CrossRefGoogle ScholarPubMed
Tienari, P. (1992a) Implications of adoption studies on schizophrenia. British Journal of Psychiatry, 161 (suppl. 18), 52–58.Google Scholar
Tienari, P. (1992b) Interaction between genetic vulnerability and rearing environment. In Psychotherapy of Schizophrenia: Facilitating and Obstructive Factors (eds Werbart, A. & Cullberg, J.), pp. 154–172. Oslo: Universitetsforlaget.Google Scholar
Tienari, P., Sorri, A., Lahti, I., et al (1985) Interaction of genetic and psychosocial factors in schizophrenia. Acta Psychiatrica Scandinavica, 71 (suppl. 319), 19–30.Google Scholar
Tienari, P., Lahti, I., Sorri, A., et al (1990) Adopted-away offspring of schizophrenics and controls: the Finnish adoptive family study of schizophrenia. In Straight and Devious Pathways from Childhood to Adulthood (eds Robins, L. & Rutter, M.), pp. 365–379. New York: Cambridge University Press.Google Scholar
Wachs, T. D. (1983) The use and abuse of environment in behavior–genetic research. Child Development, 54, 396–407.Google Scholar
Wahlberg, K.-E., Wynne, L. C., Keskitalo, P., et al (1991) Genetic versus environmental Rorschach variables in the Finnish adoptive family study of schizophrenia (abstract). Schizophrenia Research, 4, 309.CrossRefGoogle Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.Google Scholar
Wynne, L. C., Singer, M. T. & Toohey, M. L. (1976) Communication of the adoptive parents of schizophrenics. In Schizophrenia 75 (eds Jorstad, J. & Ugelstad, E.), pp. 413–451. Oslo: Universitetsforlaget.Google Scholar
Wynne, L. C., Singer, M. T., Bartko, J. J., et al (1977) Schizophrenics and their families: research on parental communication. In Developments in Psychiatric Research (ed. Tanner, M.), pp. 254–286. London: Hodder & Stoughton.Google Scholar
Wynne, L. C., Jones, J. E. & Al-Khayyal, M. (1982) Healthy family communication patterns: observations in families ‘at risk’ for psychopathology. In Normal Family Processes (ed. Walsh, F.), pp. 142–164. New York: Guilford Press.Google Scholar
Wynne, L. C. & Cole, R. E. (1983) The Rochester risk research program: a new look at parental diagnoses and family relationships. In Psychosocial Intervention in Schizophrenia: an International View (eds Stierlin, H., Wynne, L. C. & Wirsching, M.), pp. 25–48. Berlin: Springer.Google Scholar
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