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Familial Tourette's Syndrome in a Large British Pedigree

Associated Psychopathology, Severity, and Potential for Linkage Analysis

Published online by Cambridge University Press:  03 January 2018

Mary M. Robertson  and
Alison Gourdie
Mary M. Robertson*
Affiliation:
Institute of Neurology, Academic Department of Psychiatry, University College and Middlesex School of Medicine, Wolfson Building, Riding House Street, London W1N 8AA
Alison Gourdie
Affiliation:
Academic Department of Psychiatry, University College and Middlesex School of Medicine
*
∗Correspondence
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Abstract

A British pedigree multiply affected by the Gilles de la Tourette syndrome and spanning six generations is described. Of 122 members identified, 85 were individually interviewed, and 50 were diagnosed as ‘cases'. ‘Cases' consisted of 29 with definite or probable Gilles de la Tourette syndrome, 17 with definite or probable chronic multiple tics, and four with definite or probable obsessive-compulsive behaviour. Only eight of the 50 ‘cases' had consulted a doctor for their symptoms. ‘Cases' and ‘non-cases' could be distinguished on the basis of echo-phenomena, obsessive-compulsive features, self-injurious behaviour, and the trait score of the Leyton Obsessional Inventory, but did not differ significantly on any other psychopathological variables. The pattern of inheritance of the Gilles de la Tourette syndrome in this pedigree is consistent with autosomal dominant transmission.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 156 , Issue 4 , April 1990 , pp. 515 - 521
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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