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Evidence for a Pseudoautosomal Locus for Schizophrenia

II: Replication of a Non-random Segregation of Alleles at the DXYS14 Locus

Published online by Cambridge University Press:  02 January 2018

T. D'Amato ,
D. Campion ,
Ph. Gorwood ,
M. Jay ,
O. Sabate ,
C. Petit ,
M. Abbar ,
A. Malafosse ,
M. Leboyer  and
D. Hillaire
...Show all authors
T. D'Amato
Affiliation:
CNRS, F-91198 Gif-sur-Yvette, and CHS “Le Vinatier” (Pr Dalery), F-69677 Lyon-Bron, France
D. Campion
Affiliation:
Département de Recherche, F-76300 Sotteville-les-Rouens, and Laboratoire de Génétique Epidémiologique, INSERM U-155, Château de Longchamp, F-75016 Paris
Ph. Gorwood
Affiliation:
INSERM U-155, Cháteau de Longchamp, F-75016 Paris
M. Jay
Affiliation:
97460 St Paul, La Réunion
O. Sabate
Affiliation:
CNRS, F-91198 Gif-sur-Yvette
C. Petit
Affiliation:
INSERM-U-163, CNRS UA-271, Institut Pasteur, F-75015 Paris
M. Abbar
Affiliation:
F-34059 Montpellier
A. Malafosse
Affiliation:
CNRS, F-91198 Gif-sur-Yvette
M. Leboyer
Affiliation:
F-75651 Paris
D. Hillaire
Affiliation:
INSERM, 97405 St Denis, La Réunion
F. Clerget-Darpoux
Affiliation:
INSERM U-155, Château de Longchamp, F-75016 Paris
J. Feingold
Affiliation:
INSERM U-155, Château de Longchamp, F-75016 Paris
G. Waksman
Affiliation:
CNRS, F-91198 Gif-sur-Yvette
J. Mallet*
Affiliation:
CNRS, F-91198 Gif-sur-Yvette, France
*
∗Laboratoire NBCM, CNRS UPR0023, 1 Avenue de la Terrasse, 91–198 Gif-sur-Yvette, France
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Abstract

Because of an association between sexual aneuploidies and schizophrenia, and because schizophrenic siblings have been found to be more often of the same than of the opposite sex, the susceptibility locus for schizophrenia is thought to lie within the pseudoautosomal region of the sex chromosomes. We analysed 33 sibships comprising 18 pairs, 13 trios, and 2 quartets of affected siblings, and found support for non-random segregation of alleles at the DXYS14 locus in affected siblings. These findings are consistent with the pseudoautosomal hypothesis for schizophrenia and favour a genetic linkage between DXYS 14 and the disease.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 1 , July 1992 , pp. 59 - 62
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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