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Drug Treatment of the Personality Disorders

Published online by Cambridge University Press:  02 January 2018

George Stein
George Stein*
Affiliation:
King's College Hospital, and Farnborough Hospital, Farnborough Common, Orpington, Kent BR6 8ND
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Abstract

Many people with well defined borderline and schizotypal personality disorders may benefit considerably from small doses of neuroleptics. Depression that occurs with personality disorders, which is frequent, responds poorly to tricyclics but may respond better to neuroleptics, while the response to ECT is usually short lived. Selected borderline subjects may respond to MAOIs, particularly where there is a history of childhood hyperactivity. Carbamazepine and lithium may help some individuals with episodic behavioural dyscontrol and aggression, even in the absence of epileptic, affective or organic features. Drug treatments can be combined with psychotherapy, but further placebo-controlled trials are needed to clarify which drugs are most useful, and whether there are any useful clinical predictors of drug responsiveness.

Type
Review Articles
Information
The British Journal of Psychiatry , Volume 161 , Issue 2 , August 1992 , pp. 167 - 184
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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