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Double-Blind, Placebo-Controlled, Crossover Trial of Glycine Adjuvant Therapy for Treatment-Resistant Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Uriel Heresco-Levy ,
Daniel C. Javitt ,
Marina Ermilov ,
Clara Mordel ,
Avraham Horowitz  and
Dalia Kelly
Uriel Heresco-Levy*
Affiliation:
Ezrath Nashim–Herzog Memorial Hospital and Department of Psychiatry, Hadassah Medical School–Hebrew University, Jerusalem, Israel
Daniel C. Javitt
Affiliation:
Nathan S. Kline Institute for Psychiatric Research, and Department of Psychiatry, New York University Medical Center, New York, USA
Marina Ermilov
Affiliation:
Ezrath Nashim–Herzog Memorial Hospital, Jerusalem, Israel
Clara Mordel
Affiliation:
Ezrath Nashim–Herzog Memorial Hospital, Jerusalem, Israel
Avraham Horowitz
Affiliation:
Ezrath Nashim–Herzog Memorial Hospital, Jerusalem, Israel
Dalia Kelly
Affiliation:
Ezrath Nashim–Herzog Memorial Hospital, Jerusalem, Israel
*
Uriel Heresco-Levy, Psychiatry Department, Ezrath Nashim–Herzog Memorial Hospital, P.O. Box 35300, Jerusalem 91351, Israel. Fax: (02) 653 6075
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Abstract

Background

It has been proposed that schizophrenia is associated with underactivity of brain glutamatergic neurotransmission, especially at the level of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. Glycine potentiates NMDA receptor-mediated neurotransmission, indicating that it may serve as an effective therapeutic agent in the treatment of schizophrenia.

Method

Eleven treatment-resistant patients with chronic schizophrenia completed a double-blind placebo-controlled, six-week, randomly assigned, crossover treatment trial of 0.8 g/kg body weight/day of glycine, added to their prior antipsychotic treatment.

Results

Glycine was well tolerated, resulted in significantly increased serum glycine levels and induced a mean 36 (7%) reduction in negative symptoms (P < 0.0001). Significant improvments were also induced in depressive and cognitive symptoms. The greatest reduction in negative symptoms was registered in the patients who had the lowest baseline serum glycine levels.

Conclusions

These results extend previous findings and suggest an additional approach to the pharmacotherapy of negative symptoms and cognitive deficits in schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 169 , Issue 5 , November 1996 , pp. 610 - 617
Copyright
Copyright © Royal College of Psychiatrists, 1996 

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