Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-30T15:06:21.907Z Has data issue: false hasContentIssue false
  • English
  • Français

A Double-Blind Comparison of Dothiepin and Amitriptyline in Patients with Primary Affective Disorder: Serum Levels and Clinical Response

Published online by Cambridge University Press:  29 January 2018

J. Mendlewicz ,
P. Linkowski  and
J. A. Rees
J. Mendlewicz
Affiliation:
Erasme Hospital, University of Brussels, Route de Lennick, 808, 1070 Brussels, Belgium
P. Linkowski
Affiliation:
Erasme Hospital, University of Brussels, Route de Lennick, 808, 1070 Brussels, Belgium
J. A. Rees
Affiliation:
Research Department, The Boots Company Ltd., Nottingham, England
Get access Rights & Permissions [Opens in a new window]

Summary

In a double-blind parallel group study, thirty-two patients suffering from a primary affective disorder received either dothiepin or amitriptyline. Serum concentrations of total dothiepin plus northiaden or amitriptyline and nortriptyline were estimated. A similar therapeutic response was seen with both drugs but there was no correlation with serum concentrations of amitriptyline or nortriptyline, whereas serum dothiepin correlated positively with clinical response.

Type
Papers
Information
The British Journal of Psychiatry , Volume 136 , Issue 2 , February 1980 , pp. 154 - 160
Copyright
Copyright © Royal College of Psychiatrists, 1980 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Åsberg, M., Crönholm, B., SjöQvist, F. & Tuck, D. (1971) Relationship between plasma level and therapeutic effect of nortriptyline. British Medical Journal, iii, 331–4.Google Scholar
Bradley, J. V. (1968) Distribution-free Statistical Tests, Pp. 105–14. USA: Prentice-Hall.Google Scholar
Braithwaite, R. A., Goulding, R., Theano, G., Bailey, J. & Coppen, A. (1972) Plasma concentration of amitriptyline and clinical response. Lancet, i, 1297–1300.Google Scholar
Braithwaite, R. A. & Widdop, B. (1971) A specific gas chromatographic method for the measurement of ‘steady-state’ plasma levels of amitriptyline and nortriptyline in patients. Clinica Chimica Acta, 35, 461–72.CrossRefGoogle ScholarPubMed
Burrows, G. D., Davies, B. & Scoggins, B. A. (1972) Plasma concentration of nortriptyline and clinical response in depressive illness. Lancet, ii, 619–23.Google Scholar
Coppen, A., Ghose, K., Montgomery, S., Rama Rao, V. A., Bailey, J., Christiansen, J., Mikkleson, P. L., Van Praag, H. M., Van de Poel, F., Minsker, E. J., Kozulja, V. G., Matussek, N., Kungkunz, G. & Jørgensen, A. (1978) Amitriptyline plasma concentration and clinical effect. A World Health Organization Collaborative Study. Lancet, i, 63–6.Google Scholar
Endicott, J. & Spitzer, R. L. (1972) Current and past psychopathology scales: rationale, reliability and validity. Archives of General Psychiatry, 27, 678–87.Google Scholar
Fairchild, R. (1975) A gas chromatographic method for the assay of dothiepin in serum. (Unpublished. Available from Rees, J. A., Research Department, The Boots Co. Ltd., Nottingham).Google Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle ScholarPubMed
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.CrossRefGoogle ScholarPubMed
Kragh-Sorensen, P., Åsberg, M. & Eggert-Hansen, C. (1973) Plasma nortriptyline levels in endogenous depression. Lancet, i, 113–15.Google Scholar
Kupfer, D. J., Hanin, I., Spiker, D. G., Grau, T. & Coble, T. (1977) Amitriptyline plasma levels and clinical response in primary depression. Clinical Pharmacology and Therapeutics, 22, 904–11.Google Scholar
Lipsedge, M. S., Linford Rees, W. & Pike, D. J. (1971) A double-blind comparison of dothiepin and amitriptyline for the treatment of depression with anxiety. Psychopharmacologia, 19, 153–62.CrossRefGoogle ScholarPubMed
Montgomery, S. A., McAuley, R., Arani, S. J., Montgomery, D. D., Braithwaite, R. & Dawling, S. (1979) Amitriptyline plasma concentrations and clinical response. British Medical Journal, 230–1.CrossRefGoogle Scholar
Perel, J. M., Mendlewicz, J., Shostak, M., Kantor, S. J. & Glassman, A. H. (1976) Plasma levels of imipramine in depression. Environmental and genetic factors. Neuropsychobiology, 2, 193–202.CrossRefGoogle ScholarPubMed
Siegel, S. (1956) Nonparametric Statistics for the Behavioural Sciences, Pp. 213–229. USA: McGraw-Hill.Google Scholar
Sim, M., Reid, D., Pallett, J. & Gordon, E. (1975) The Hamilton rating scale. An assessment based on a dothiepin (‘Prothiaden’) versus imipramine (‘Tofranil’) clinical trial. International Pharmacopsychiatry, 10, 142–8.Google Scholar
The General Practitioner Research Group (1976) A comparison between dothiepin and doxepin in the treatment of depression. The Practitioner, 216, 581–3.Google Scholar
Ziegler, V. E., Clayton, P. J., Taylor, J. R., Co, B. T. & Biggs, J. T. (1976) Nortriptyline plasma levels and therapeutic response. Clinical Pharmacology and Therapeutics, 20, 458–63.Google Scholar
Ziegler, V. E., Clayton, P. J. & Biggs, J. T. (1977) A comparison study of amitriptyline and nortriptyline with plasma levels. Archives of General Psychiatry, 34, 607–12.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.