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Does previous experience of antidepressants form the expectations necessary for a placebo response?

Published online by Cambridge University Press:  02 January 2018

Nathan T. M. Huneke  and
David S. Baldwin
Nathan T. M. Huneke
Affiliation:
Psychiatry ACFST1, University of Southampton, UK. Email: [email protected]
David S. Baldwin
Affiliation:
University of Southampton, UK
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Abstract

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The British Journal of Psychiatry , Volume 207 , Issue 6 , December 2015 , pp. 561
Copyright
Copyright © Royal College of Psychiatrists, 2015 

We thank Dr McKenna (and colleagues) for his interest in our editorial, and respect his long record of research into schizophrenia. His point about the authors of influential national clinical guidelines such as NICE, the British Association for Psychopharmacology (BAP) and the Scottish Intercollegiate Guidelines Network (SIGN) needing to take negative evidence into account is well made, and analogous to the AllTrials movement in pharmacotherapeutics. Schizophrenia is such a common and potentially devastating illness that it is incumbent on mental health professionals such as psychologists and psychiatrists to work together to deliver best-evidenced treatments.

References

1 Leuchter, AF, Hunter, AM, Tartter, M, Cook, IA. Role of pill-taking, expectation and therapeutic alliance in the placebo response in clinical trials for major depression. Br J Psychiatry 2014; 205: 443–9.CrossRefGoogle ScholarPubMed
2 Benedetti, F, Carlino, E, Pollo, A. How placebos change the patient's brain. Neuropsychopharmacology 2011; 36: 339–54.Google Scholar
3 Price, DD, Milling, LS, Kirsch, I, Duff, A, Montgomery, GH, Nicholls, SS. An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain 1999; 83: 147–56.Google Scholar
4 Morton, DL, Brown, CA, Watson, A, El-Deredy, W, Jones, AKP. Cognitive changes as a result of a single exposure to placebo. Neuropsychologia 2010; 48: 1958–64.Google Scholar
5 Huneke, NTM, Brown, CA, Burford, E, Watson, A, Trujillo-Barreto, NJ, El-Deredy, W, et al. Experimental placebo analgesia changes resting-state alpha oscillations. PLoS One 2013; 8: e78278.CrossRefGoogle ScholarPubMed
6 Watson, A, El-Deredy, W, Vogt, BA, Jones, AKP. Placebo analgesia is not due to compliance or habituation: EEG and behavioural evidence. Neuroreport 2007; 18: 771–5.Google Scholar
7 Petrovic, P, Dietrich, T, Fransson, P, Andersson, J, Carlsson, K, Ingvar, M. Placebo in emotional processing–induced expectations of anxiety relief activate a generalized modulatory network. Neuron 2005; 46: 957–69.CrossRefGoogle ScholarPubMed
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