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Depression, Weight Loss and the Dexamethasone Suppression Test

Published online by Cambridge University Press:  29 January 2018

Alec Coppen ,
Janet Harwood  and
Keith Wood
Alec Coppen*
Affiliation:
West Park Hospital, Epsom, Surrey
*
∗Correspondence.
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Summary

The dexamethasone suppression test (DST) was carried out on 143 patients with a major depressive disorder, who were classified into those with a history of weight loss (n = 89) and those without (n = 54). Seventy-three per cent of patients with weight loss and 61% of patients without had an abnormal DST; this difference was not statistically significant. Of the patients receiving prophylactic lithium therapy, 13 were found to have changed their DST status on retesting after a period of 14 months, but there was no significant difference in their weight. It is concluded that weight loss is not a necessary condition for an abnormal DST in depressive illness.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 145 , Issue 1 , July 1984 , pp. 88 - 90
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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References

Berger, M., Pirke, K. M., Dorr, P., Krieg, C. & von Zerssen, D. (1983) Influence of weight loss on the dexamethasone suppression test. Archives of General Psychiatry, 40, 585–8.CrossRefGoogle ScholarPubMed
Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and prediction of ECT response. British Journal of Psychiatry, 111, 659–74.Google Scholar
Carroll, B. J. (1982) The dexamethasone suppression test for melancholia. British Journal of Psychiatry, 140, 292–304.CrossRefGoogle ScholarPubMed
Coppen, A., Abou-Saleh, M., Milln, P., Metcalfe, M., Harwood, J. & Bailey, J. (1983) Dexamethasone suppression test in depression and other psychiatric illness. British Journal of Psychiatry, 142, 498–504.Google Scholar
Edelstein, C. K., Roy-Byrne, P., Fawzy, F. I. & Dornfield, L. (1983) Effects of weight loss on the dexamethasone suppression test. American Journal of Psychiatry, 140, 338–41.Google Scholar
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Clinical and Social Psychology, 6, 278–96.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research diagnostic criteria: Rationale and reliability. Archives of General Psychiatry, 35, 773–82.Google Scholar
Targum, S. D. (1983) Reported weight loss and the dexamethasone suppression test. Psychiatry Research, 9, 173–4.Google Scholar
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