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Cytogenetic Studies in the Offspring of Lsd Users

Published online by Cambridge University Press:  29 January 2018

J. Fernandez ,
T. Brennan ,
J. Masterson  and
M. Power
J. Fernandez
Affiliation:
St. Brendan's Hospital, Dublin, 7, Ireland
T. Brennan
Affiliation:
St. Brendan's Hospital, Dublin, 7, Ireland
J. Masterson
Affiliation:
Department of Pathology, University College Dublin, Ireland
M. Power
Affiliation:
Department of Pathology, University College Dublin, Ireland
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Extract

The presumed carcinogenic and chromosome-breaking potential of d-lysergic acid diethylamide (d-LSD 25) in human somatic cells has been reviewed by Fernandez et al. (1973). Reports concerning its teratogenic effect in experimental animals and man have been either contradictory or inconclusive. The following possible teratogenic mechanisms may be considered: (1) A direct effect on organogenesis of LSD ingested by the mother during early pregnancy; (2) A similar disturbance of organogenesis by a persistent metabolite of LSD ingested by the mother at some time prior to the pregnancy; (3) Chromosome damage or point mutations in parental germ cells exposed to LSD before initiation of a pregnancy.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 124 , Issue 580 , March 1974 , pp. 296 - 298
Copyright
Copyright © Royal College of Psychiatrists, 1974 

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