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Cyclic AMP in the CSF of Patients with Schizophrenia

Published online by Cambridge University Press:  29 January 2018

J. Biederman ,
R. Rimon ,
R. Ebstein ,
R. H. Belmaker  and
J. T. Davidson
J. Biederman
Affiliation:
Jerusalem Mental Health Centre, POB 140, Jerusalem, Israel
R. Rimon
Affiliation:
Jerusalem Mental Health Centre, POB 140, Jerusalem, Israel
R. Ebstein
Affiliation:
Jerusalem Mental Health Centre, POB 140, Jerusalem, Israel
R. H. Belmaker
Affiliation:
Jerusalem Mental Health Centre, POB 140, Jerusalem, Israel
J. T. Davidson
Affiliation:
Hadassah Hospital, Hebrew University of Jerusalem
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Summary

The dopamine hypothesis of schizophrenia proposes that schizophrenia is associated with increased brain dopaminergic function. Because dopamine is thought to stimulate the production of cyclic AMP in the brain, we hypothesized that CSF cyclic AMP would be increased in schizophrenia. Cyclic AMP in the CSF was determined in 19 schizophrenic patients who had not received neuroleptic treatment in the preceding two weeks. No significant difference could be shown between CSF cyclic AMP in these patients and CSF cyclic AMP in 10 psychiatrically normal controls.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 130 , Issue 1 , January 1977 , pp. 64 - 67
Copyright
Copyright © Royal College of Psychiatrists 1977 

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