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Creatine Phosphokinase and Psychiatric Illness

Published online by Cambridge University Press:  29 January 2018

Lynn A. Cunningham ,
Charles L. Rich ,
Robert A. Woodruff Jr.  and
John W. Olney
Lynn A. Cunningham
Affiliation:
Washington University School of Medicine, St Louis, Missouri 63110, U.S.A
Charles L. Rich
Affiliation:
Washington University School of Medicine, St Louis, Missouri 63110, U.S.A
Robert A. Woodruff Jr.
Affiliation:
Washington University School of Medicine, St Louis, Missouri 63110, U.S.A
John W. Olney
Affiliation:
Washington University School of Medicine, St Louis, Missouri 63110, U.S.A
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Extract

Since Schiavone and Kaldor (16) reported the incidental finding of increased creatine Phosphokinase (CPK) in patients with schizophrenia a number of studies of the enzyme have appeared in the literature. Bengzon et al. (2), reported among a group of 30 schizophrenics, CPK elevations, which returned to normal during the course of treatment with phenothiazines. These authors investigated a second group of 60 untreated patients who were ‘acutely psychotic’ and found abnormally high CPK levels in half of them. However no mention was made of diagnostic criteria, nor of attempts to control for extraneous circumstances known to elevate the enzyme.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 124 , Issue 578 , January 1974 , pp. 87 - 91
Copyright
Copyright © Royal College of Psychiatrists, 1974 

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Footnotes

∗.

This work was supported in part by U.S.P.H.S. grants MH-19972, 13002, 09247, 05804, and by NS-09156.

A synopsis of this paper was published in the April 1973 Journal.

References

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