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Conventional versus atypical neuroleptics: subjective quality of life in schizophrenic patients

Published online by Cambridge University Press:  03 January 2018

M. Franz ,
Stefanie Lis ,
K. Plüddemann  and
B. Gallhofer
M. Franz
Affiliation:
Centre for Psychiatry, Justus-Liebig University, Giessen, Germany
Stefanie Lis*
Affiliation:
Centre for Psychiatry, Justus-Liebig University, Giessen, Germany
K. Plüddemann
Affiliation:
Centre for Psychiatry, Justus-Liebig University, Giessen, Germany
B. Gallhofer
Affiliation:
Centre for Psychiatry, Justus-Liebig University, Giessen, Germany
*
Dr Michael Franz.Centre for Psychiatry, Justus-Liebig University, School of Medicine, Am Steg 22, D-3838S Giessen, Germany
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Abstract

Background

The effectiveness of anti-psychotic drugs against positive psychotic symptoms has been demonstrated in many studies, but their effects on quality of life have yet to be clarified. The impact of different neuroleptic therapies on the subjective quality of life of schizophrenic patients is evaluated in a cross-sectional open study.

Method

During a four-month period a standardised quality of life interview for schizophrenic patients was applied on day 10 after admission; 33 patients on atypical neuroleptics (AAP) were compared with 31 matched patients on conventional neuroleptics (CAP).

Results

The AAP group had significantly higher scores in general quality of life as well as in different life domains: physical well-being, social life and everyday life. In separate comparisons of the AAP group, patients on clozapine and risperidone were found to have a higher quality of life score than patients on CAP or zotepine.

Conclusions

The pharmacological profile of clozapine and risperidone may provide a basis for explaining the higher subjective quality of life found in this study. The lower quality of life of the CAP group may possibly be related to intrinsic effects of the conventional antipsychotics.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 5 , May 1997 , pp. 422 - 425
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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