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Concurrent Agranulocytosis and Hepatitis Secondary to Clomipramine Therapy

Published online by Cambridge University Press:  02 January 2018

Christopher P. Alderman ,
Michelle M. Atchison  and
Janet I. McNeece
Christopher P. Alderman*
Affiliation:
Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia 5041
Michelle M. Atchison
Affiliation:
The Queen Elizabeth Hospital, Woodville, South Australia
Janet I. McNeece
Affiliation:
Drug and Therapeutics Information Service, Repatriation General Hospital, South Australia
*
∗ Correspondence
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Abstract

A 67-year-old man developed concurrent severe agranulocytosis and elevation of hepatic transaminases as a result of treatment with clomipramine. Although such adverse drug reactions can be considered rare events, the potentially serious nature of these reactions vindicate the routine monitoring of blood picture, and liver function tests, after initiation of treatment with tricyclic antidepressants.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 162 , Issue 5 , May 1993 , pp. 688 - 689
Copyright
Copyright © Royal College of Psychiatrists, 1993 

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