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A Comparison of Paroxetine, Imipramine and Placebo in Depressed Out-patients

Published online by Cambridge University Press:  02 January 2018

G. C. Dunbar ,
J. B. Cohn ,
L. F. Fabre ,
J. P. Feighner ,
R. R. Fieve ,
J. Mendels  and
R. K. Shrivastava
G. C. Dunbar*
Affiliation:
CNS Therapeutic Unit, Clinical Research and Development, SmithKline Beecham Pharmaceuticals
J. B. Cohn
Affiliation:
Psychopharmacology Research Institute, Long Beach
L. F. Fabre
Affiliation:
Research Testing, Inc.
J. P. Feighner
Affiliation:
Feighner Research Institute
R. R. Fieve
Affiliation:
The Foundation for Depression and Manic Depression, Inc.
J. Mendels
Affiliation:
Philadelphia Medical Institute
R. K. Shrivastava
Affiliation:
Eastside Comprehensive Medical Services, New York
*
∗47–49 London Road, Reigate, Surrey RH2 9YF
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Abstract

To compare the safety and antidepressant efficacy of paroxetine, imipramine, and placebo, data from six centres using the same protocol were pooled. A double-blind parallel-group design was used, with therapy lasting six weeks. From week 2 onwards, both the 240 paroxetine-treated and the 237 imipramine-treated patients were significantly different from the 240 placebo-treated patients, but no different from each other. Side-effects with paroxetine were less likely to lead to drop-out than with imipramine. Paroxetine had a possible earlier antidepressant effect than imipramine, and a possible earlier beneficial effect on anxiety symptoms associated with depression.

Type
Papers
Information
The British Journal of Psychiatry , Volume 159 , Issue 3 , September 1991 , pp. 394 - 398
Copyright
Copyright © 1991 The Royal College of Psychiatrists 

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