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Clinical Pharmacology and Pharmacokinetics of Fluoxetine: A Review

Published online by Cambridge University Press:  06 August 2018

R. F. Bergstrom ,
L. Lemberger ,
N. A. Farid  and
R. L. Wolen
R. F. Bergstrom*
Affiliation:
Lilly Laboratory for Clinical Research, Eli Lilly and Company, and the Departments of Pharmacology, Medicine and Psychiatry, Indiana University School of Medicine
L. Lemberger
Affiliation:
Lilly Laboratory for Clinical Research, Eli Lilly and Company, and the Departments of Pharmacology, Medicine and Psychiatry, Indiana University School of Medicine
N. A. Farid
Affiliation:
Lilly Laboratory for Clinical Research, Eli Lilly and Company, and the Departments of Pharmacology, Medicine and Psychiatry, Indiana University School of Medicine
R. L. Wolen
Affiliation:
Lilly Laboratory for Clinical Research, Eli Lilly and Company, and the Departments of Pharmacology, Medicine and Psychiatry, Indiana University School of Medicine
*
∗Correspondence
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Extract

Drugs are discovered by a variety of approaches, which include a systematic evaluation of synthetic compounds, using extensive structure activity relationships. After a lead compound which possesses desirable pharmacological properties is found, through the exhaustive screening of a variety of compounds, a number of congeners are then synthesised and tested, using specific physiological or biochemical models of therapeutic agents. The discovery of fluoxetine involved this complex process, and led to the description in the literature of one of the first selective serotonin uptake inhibitors (Wong et al, 1974); it was subsequently tested clinically, and these studies demonstrated its effectiveness and safety as an antidepressant drug (Chouinard, 1985). This paper reviews the published information relevant to fluoxetine's pharmacology and pharmacokinetics in man.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 153 , Issue S3: Progress in Antidepressant Therapy , September 1988 , pp. 47 - 50
Copyright
Copyright © 1988 The Royal College of Psychiatrists 

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References

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