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Cerebral Ventricular Enlargement in Non-Genetic Schizophrenia: a Controlled Twin Study

Published online by Cambridge University Press:  29 January 2018

Adrianne M. Reveley*
Affiliation:
Institute of Psychiatry, de Crespigny Park, SE5 8AF
Michael A. Reveley
Affiliation:
Institute of Psychiatry, de Crespigny Park, SE5 8AF
Robin M. Murray
Affiliation:
Institute of Psychiatry, de Crespigny Park, SE5 8AF
*
Correspondence

Summary

In a group of schizophrenics of twin birth, no evidence of ventricular enlargement was found where there was a family history of major psychiatric disorder. Among those schizophrenics without such a family history, cerebral ventricular size was significantly increased (P <0.01), and there was also evidence of birth complications. Among normal control twins, those who reported complicated births had significantly larger ventricles.

Type
Research Article
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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References

Farr, V. (1975) Prognosis for the babies, early and late. In Human Multiple Reproduction (eds. MacGillivray, I., Nylander, P. P. S. and Corney, G.), pp. 188211. London: W. B. Saunders.Google Scholar
Gottesman, I. I. & Shields, J. (1972) Schizophrenia and Genetics. A Twin Study Vantage Point. New York and London: Academic Press.Google Scholar
Gottesman, I. I. & Shields, J. (1982) Schizophrenia: The Epigenetic Puzzle. Cambridge: Cambridge University Press.Google Scholar
Haug, J. O. (1962) Pneumoencephalographic studies in mental disease. Acta Psychiatrica Scandinavica, 38, Supplement 165.Google ScholarPubMed
Rett, S. S., Rosenthal, D., Wender, P. H., Schulsinger, F. & Jacobsen, B. (1975) Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic. In Genetic Research in Psychiatry (eds. Fieve, R. R., Rosenthal, D. and Brill, H.), pp.147–65. Baltimore: Johns Hopkins Press.Google Scholar
Lancet Editorial (1982) The CT scan in schizophrenia. Lancet, ii, 968.Google Scholar
McNeil, T. F. & Kaij, L. (1978) Obstetric factors in the development of schizophrenia. In The Nature of Schizophrenia (eds. Wynne, L. C., Cromwell, R. L. and Matthysse, S.), pp. 401–29. New York: John Wiley.Google Scholar
Norman, M. G. (1982) Mechanisms of brain damage in twins. Canadian Journal of Neurological Science, 9.3, 339–44.Google Scholar
Propping, P. (1983) Genetic disorders presenting as ‘schizophrenia’. Human Genetics (in press).Google Scholar
Reveley, A. M. & Reveley, M. A. (1983) Aqueduct stenosis and schizophrenia. Journal of Neurology, Neurosurgery and Psychiatry, 46, 1822.CrossRefGoogle ScholarPubMed
Reveley, A. M., Gurling, H. M. D. & Murray, R. M. (1981) Mortality and psychosis in twins. Progress in Clinical and Biological Research, 69b, 175–8.Google Scholar
Reveley, A. M., Reveley, M. A., Clifford, C. A. & Murray, R. M. (1982) Cerebral ventricular size in twins discordant for schizophrenia. Lancet, i, 540–1.Google Scholar
Rieder, R. O., Mann, L. S., Weinberger, D. R., van Kammen, D. P. & Post, R. M. (1983) Computerised tomographic scans in patients with schizophrenia, schizoaffective and bipolar affective disorder. Archives of General Psychiatry, 40, 735–9.Google Scholar
Schulsinger, F. (1982) Paper presented to the Royal College of Psychiatrists at the Institute of Psychiatry, London.Google Scholar
Slater, E. T. O. & Cowie, V. (1971) The Generics of Mental Disorders, pp. 27–8. London: Oxford University Press.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1975) Research Diagnostic Criteria. Instrument No. 58. New York: New York State Psychiatric Institute.Google Scholar
Spitzer, R. L., Endicott, J. (1977) The Schedule for Affective Disorders and Schizophrenia, Lifetime Version, 3rd ed. New York: New York State Psychiatric Institute.Google Scholar
Thompson, W. D., Orvaschel, H., Prusoff, B. A. & Kidd, K. K. (1982) An evaluation of the family history method for ascertaining psychiatric disorders. Archives of General Psychiatry, 39, 53–8.Google Scholar
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