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Behavioural pharmacology of the new generation of antipsychotic agents

Published online by Cambridge University Press:  06 August 2018

N. A. Moore
N. A. Moore*
Affiliation:
Lilly Research Centre, Eli Lilly & Co., Erl Wood Manor, Windlesham, Surrey GU20 6PH. Tel: 44 (0) 1276 853553. Fax: 44 (0) 1276 853525. e-mail: [email protected]
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Extract

Antipsychotic agents have been the mainstay in the management of schizophrenia for a number of years. Their therapeutic efficacy is primarily attributed to dopamine receptor antagonism (Creese et al, 1976), leading to a reduction in the positive symptoms of schizophrenia such as paranoia and hallucinations. Unfortunately, they have little effect on the negative symptoms (such as flattened affect, poverty of speech, anhedonia and social withdrawal) or cognitive deficits. The blockade of central dopamine receptors by classical antipsychotic agents also leads to the development of both acute and chronic motor disturbances (extrapyramidal side-effects) (EPS) (Meltzer, 1992).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 174 , Issue S38: New antipsychotics - preclinical and clinical comparisons , May 1999 , pp. 5 - 11
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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