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Altered Magnetic Resonance White-Matter T1 Values in Patients with Affective Disorder

Published online by Cambridge University Press:  02 January 2018

R. J. Dolan ,
A. M. Poynton ,
P. K. Bridges  and
M. R. Trimble
R. J. Dolan*
Affiliation:
Royal Free Hospital School of Medicine, Pond St, London NW3, and National Hospital for Nervous Diseases, Queen Square, London WC1
A. M. Poynton
Affiliation:
York Clinic, Guy's Hospital, London Bridge, London SE1 9RT
P. K. Bridges
Affiliation:
Guy's Hospital Medical School, London SE1 9RT
M. R. Trimble
Affiliation:
The National Hospital for Nervous Diseases, and Institute of Neurology, London WC1
*
∗Correspondence
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Abstract

The MRI T1 proton relaxation values were assessed in 14 patients with bipolar affective disorder and 10 with a unipolar disorder and a matched normal control group. The T1 values in the frontal white matter of patients significantly exceeded those of the controls. This difference was accounted for by an increase in T1 values in the frontal white matter of unipolar patients: the values for bipolar patients alone did not differ from those for controls. These preliminary findings support a hypothesis of frontal lobe dysfunction mediating pathological changes in mood.

Type
Papers
Information
The British Journal of Psychiatry , Volume 157 , Issue 1 , July 1990 , pp. 107 - 110
Copyright
Copyright © The Royal College of Psychiatrists 

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