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The Withdrawal of Benztropine Mesylate in Chronic Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

Linda A. Baker ,
L. Y. Cheng  and
I. B. Amara
Linda A. Baker
Affiliation:
Department of Psychology, Queen's University, Kingston, Ontario, Canada
L. Y. Cheng
Affiliation:
Department of Psychiatry, Queen's University, Kingston Psychiatric Hospital, Kingston, Ontario, Canada
I. B. Amara
Affiliation:
Kingston Psychiatric Hospital, Department of Psychiatry, Queen's University
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Summary

In this double-blind, four-week study, 28 chronic schizophrenic patients receiving neuroleptic medication plus the antiparkinsonian drug, benztropine mesylate, were either switched to placebo or maintained on benztropine. Patients withdrawn from benztropine reliably increased their overall scores on the Wechsler Memory Scale in comparison with the drug group. Sub-test scores suggest that deficits in attention and concentration were induced by treatment with benztropine. Psychotio decompensation appeared to develop simultaneously with extrapyramidal symptoms (EPS) in some patients, but only 14.2 per cent of the placebo group experienced extrapyramidal symptoms severe enough to require resumption of benztropine therapy. It is suggested that antiparkinsonian agents should be prescribed only if and when EPS occur.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 143 , Issue 6 , December 1983 , pp. 584 - 590
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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