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Whole Blood 5-Hydroxytryptamine during Treatment of Endogenous Depressive Illness

Published online by Cambridge University Press:  29 January 2018

J. J. Gayford ,
A. L. Parker ,
Eileen M. Phillips  and
A. R. Rowsell
J. J. Gayford
Affiliation:
Roffey Park Hospital, Horsham, Sussex
A. L. Parker
Affiliation:
Roffey Park Hospital, Horsham, Sussex
Eileen M. Phillips
Affiliation:
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, E.C.1
A. R. Rowsell
Affiliation:
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, E.C.1
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Extract

In the course of a study on endogenous depressive illness, whole blood 5-hydroxytryptamine (5HT) has been recorded in sixteen in-patients at Roffey Park Hospital. Thirteen patients received L-tryptophan 1 G t.d.s. and 3 G nocte, of whom two received in addition phenelzine 15 mg. b.d. for 48 hours followed by 30 mg. b.d. thereafter. Three patients received amitriptyline 25 mg. b.d. and 50 mg. nocte for 48 hours followed by 50 mg. b.d. and 75 mg. nocte thereafter. One patient receiving Ltryptophan had essential hypertension and received α-methylDOPA throughout. Observation continued for six weeks.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 122 , Issue 570 , May 1973 , pp. 597 - 598
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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References

Ashcroft, G. W., Crawford, T. B. B., Binns, J. K., and MacDougall, Elizabeth J. (1964). ‘Estimation of 5-hydroxytryptamine in human blood.’ Clin. Chim. Acta, 9, 364–9.CrossRefGoogle ScholarPubMed
Hamilton, M. (1960). ‘A rating scale for depression.’ J. Neurol. Neurosurg. Psychiat., 23, 56.CrossRefGoogle ScholarPubMed
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