Hostname: page-component-745bb68f8f-g4j75 Total loading time: 0 Render date: 2025-01-26T07:46:06.816Z Has data issue: false hasContentIssue false
  • English
  • Français

The Strength of the Genetic Effect

Is There Room for an Environmental Influence in the Aetiology of Schizophrenia?

Published online by Cambridge University Press:  02 January 2018

Peter Mcguffin ,
Philip Asherson ,
Michael Owen  and
Anne Farmer
Peter Mcguffin*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF4 4XN
Philip Asherson
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine
Michael Owen
Affiliation:
Departments of Medical Genetics and Psychological Medicine, University of Wales College of Medicine
Anne Farmer
Affiliation:
Departments of Psychological Medicine and Postgraduate Education, University of Wales College of Medicine
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

The evidence for a genetic contribution to schizophrenia is compelling. However, the pattern of inheritance is complex and it is usually assumed that environmental factors also have a role that will eventually be identified. We argue that this is not necessarily the case. While a hypothesis combining genetic diathesis with environmental stress cannot be disproved, it is also possible that ‘non-genetic’ factors consist entirely of stochastic events affecting gene expression or structure.

Type
Hypotheses
Information
The British Journal of Psychiatry , Volume 164 , Issue 5 , May 1994 , pp. 593 - 599
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adorno, T. (1973) The Jargon of Authenticity (eds & trans. K. Tarnowski & F. Will). London: Routledge & Kegan Paul.Google Scholar
Bouce, P. G. (1982) Sexuality in Eighteenth Century Britain. Manchester: Manchester University Press.Google Scholar
Crespo, E. (1986) A regional variation: emotions in Spain. In The Social Construction of Emotions (ed. Harre, R.). Oxford: Blackwell.Google Scholar
Davis, K. (1936) Jealousy and sexual property. Social Forces, 14, 395–405.CrossRefGoogle Scholar
de Rougemont, D. (1950) Passion and Society (trans. M. Belgion). London: Faber and Faber.Google Scholar
Fisher, M. (1990) Personal Love. London: Duckworth.Google Scholar
Fitzgerald, R. (1984) The Iliad. Oxford: Oxford University Press.Google Scholar
Finlay-Jones, R. (1983) Accidie and melancholy in a clinical context. Australian and New Zealand Journal of Psychiatry, 17, 149–152.CrossRefGoogle Scholar
Flynn, C. H. (1987) Defoe's idea of conduct: ideological fictions and fictional reality. In Ideology of Conduct (eds N. Armstrong & L. Tennehouse), pp. 73–95. London: Methuen.Google Scholar
Freud, S. (1955) Some neurotic mechanisms in jealousy, paranoia and homosexuality. In Standard Edition, Vol. 18 (eds & trans. J. Strachey), pp. 221–232. London: Hogarth Press.Google Scholar
Gay, P. (1984) The Bourgeois Experience: Victoria to Freud, Vol. I. The Education of the Senses. New York: Oxford University Press.Google Scholar
Gay, P. (1986) The Bourgeois Experience: Victoria to Freud, Vol. II. The Tender Passion. New York: Oxford University Press.Google Scholar
Gonzalez-Crussi, F. (1988) On the Nature of Things Erotic. London: Picador Press.Google Scholar
Hampshire, S. (1989) Innocence and Experience. Boston: Harvard University Press.Google Scholar
Heller, A. (1985) The Power of Shame: A Rational Perspective. London: Routledge & Kegan Paul.Google Scholar
Jaspers, K. (1910) Eifersuchsqahn: Zeitschrift fur die gesamte. Neurologie und Psychiatre, 1, 567–637.Google Scholar
Jones, E. (1937) Jealousy. In Papers on Psychoanalysis, pp. 469–485. London: Bailliere, Tindall.Google Scholar
Lagache, D. (1947) La Jalousie Amoureuse. Paris: Universitaires de France.Google Scholar
Lawson, A. (1987) Adultery: An Analysis of Love and Betrayal. New York: Basic Books.Google Scholar
MacIntyre, A. (1988) Whose Justice? Which Rationality? London: Duckworth.Google Scholar
MacNaughton, N. (1989) The Biology of Emotion. Oxford: Oxford University Press.CrossRefGoogle Scholar
Mercier, C. (1918) Crime and Criminals. London: University of London Press.Google Scholar
Mullen, P. E. (1990a) Morbid jealousy and the delusion of infidelity. In Principles and Practice of Forensic Psychiatry (eds R. Bluglass & P. Bowden), pp. 823–834. London: Churchill Livingstone.Google Scholar
Mullen, P. E. (1990b) A phenomenology of jealousy. Australian and New Zealand Journal of Psychiatry, 24, 17–28.CrossRefGoogle ScholarPubMed
Proust, M. (1980) Remembrance of Things Past (trans. F. Scott-Moncrieff & T. Kilmartin). New York: Random House (original 1913–1922).Google Scholar
Rawls, J. (1971) A Theory of Justice. Oxford: Clarendon Press.CrossRefGoogle Scholar
Retterstol, N. (1967) Jealousy paranoic psychosis: A personal follow-up study. Acta Psychiatrica Scandinavica, 43, 75–107.CrossRefGoogle Scholar
Scruton, R. (1986) Sexual Desire: A Philosophical Investigation. London: Weidenfeld and Nicholson.Google Scholar
Shepherd, M. (1961) Morbid jealousy: Some clinical and social aspects of a psychiatric symptom. Journal of Mental Science, 107, 607–753.CrossRefGoogle Scholar
Solomon, R. C. (1980) Emotions and choice. In Explaining Emotions (ed. A. O. Rorty). California: University of California Press.Google Scholar
Stearns, P. N. (1989) Jealousy: The Evolution of an Emotion in American History. New York: New York University Press.Google Scholar
Tiggelaar, J. (1956) Pathological jealousy and jealous delusions. Folia Psychiatrica, Neurologica et Neurochirurgica Netherlandia, 59, 522–541.Google Scholar
Tolstoy, L. (1985) The Kreutzer Sonata and Other Stories (ed. & trans. D. McDuff) (original 1892). London: Penguin Books.Google Scholar
Vaukhonen, K. (1968) On the pathogenesis of morbid jealousy. Acta Psychiatrica Scandinavica (suppl. 202).Google Scholar
White, G. L. & Mullen, P. E. (1989) Jealousy: Theory, Research and Clinical Strategies. New York: Guilford Press.Google Scholar
White, G. O. & Devine, K. (1991) Romantic jealousy: Therapists' perception of causes, consequences and treatment. Family Relations.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.