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Serum Concentration of Depot Neuroleptics in Tardive Dyskinesia

Published online by Cambridge University Press:  29 January 2018

A. F. Fairbairn ,
F. J. Rowell ,
S. M. Hui ,
F. Hassanyeh ,
A. J. Robinson  and
D. Eccleston
A. F. Fairbairn
Affiliation:
Department of Psychiatry, University of Newcastle upon Tyne, NE1 4LP
F. J. Rowell
Affiliation:
Department of Pharmaceutical Chemistry, Sunderland Polytechnic, Sunderland
S. M. Hui
Affiliation:
Department of Pharmaceutical Chemistry, Sunderland Polytechnic, Sunderland
F. Hassanyeh
Affiliation:
University of Newcastle upon Tyne
A. J. Robinson
Affiliation:
University of Newcastle upon Tyne
D. Eccleston
Affiliation:
University of Newcastle upon Tyne
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Summary

Using radioimmunoassay techniques, serum levels of depot neuroleptics, fluphenazine and flupenthixol, were estimated in two groups of chronic schizophrenic patients with, and without, tardive dyskinesia. There were high correlations between drug dose and plasma concentration. There was no significant difference in dose-related serum levels of either drug between the groups.

The hypothesis that patients with tardive dyskinesia develop the syndrome because they do not metabolise neuroleptics as efficiently as those without the syndrome was not supported by the data.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 142 , Issue 6 , June 1983 , pp. 579 - 583
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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