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Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

Published online by Cambridge University Press:  29 January 2018

J. E. Christie ,
A. Shering ,
J. Ferguson  and
A. I. M. Glen
J. E. Christie
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, 153 Morningside Drive, Edinburgh EH10 5LG
A. Shering
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, 153 Morningside Drive, Edinburgh EH10 5LG
J. Ferguson
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, 153 Morningside Drive, Edinburgh EH10 5LG
A. I. M. Glen
Affiliation:
MRC Brain Metabolism Unit, Thomas Clouston Clinic, 153 Morningside Drive, Edinburgh EH10 5LG
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Summary

Physostigmine (0.25 mg-1 mg), arecoline (2 and 4 mg) and saline were administered intravenously over 30 minutes in a randomized double blind design to 11 patients with a clinical diagnosis of Alzheimer presenile dementia. Significant improvement was seen on a picture recognition test with physostigmine 0.375 mg and arecholine 4 mg. A trend towards improvement was also seen with physostigmine 0.25 mg and 0.75 mg, and arecholine 2 mg. For the majority of the patients improvement was only slight but in two patients it was clear cut and consistent.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 138 , Issue 1 , January 1981 , pp. 46 - 50
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Bartus, R. T. (1978) Evidence for a direct cholinergic involvement in the scopolamine-induced amnesia in monkeys: effects of concurrent administration of physostigmine and methylphenidate with scopolamine. Pharmacology, Biochemistry and Behaviour, 9, 833–836.Google Scholar
Bartus, R. T. (1979) Physostigmine and recent memory: effects in young and aged nonhuman primates. Science, 206, 1087–1089.CrossRefGoogle Scholar
Blessed, G. Tomlinson, B. E. & Roth, M. (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. British Journal of Psychiatry, 114, 797–811.Google Scholar
Boyd, W. D. Graham-White, J. Blackwood, G. Glen, I. & McQueen, J. (1977) Clinical effects of choline in Alzheimer senile dementia. The Lancet, ii, 711.Google Scholar
Buschke, H. (1973) Selective reminding for analysis of memory and learning. Journal of Verbal Learning, Verbal Behavior, 12, 543–550.CrossRefGoogle Scholar
Christie, J. E. Blackburn, I. M. Glen, A. I. M. Zeisel, S. Shering, A. & Yates, C. M. (1979) Effects of choline and lecithin on CSF choline levels and on cognitive function in patients with presenile dementia of the Alzheimer type. In: Nutrition and the Brain, vol. 5 (eds. Barbeau, A. Growdon, J. H. and Wurtman, R. J.), pp 377–387. New York: Raven Press.Google Scholar
Crow, T. J. & Grove-White, I. (1973) An analysis of the learning deficit following hyoscine on human learning capacity. British Journal of Pharmacology, 49, 322–327.Google Scholar
Davies, P. & Maloney, A. J. F. (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. The Lancet, ii, 1403.Google Scholar
Davies, P. & Verth, A. H. (1978) Regional distribution of muscarinic acetylcholine receptors in normal and Alzheimer type dementia brains. Brain Research, 138, 385–392.Google Scholar
Davis, K. L. & Berger, P. A. (1978) Pharmacological investigations of the cholinergic imbalance hypothesis of movement disorders and psychosis. Biological Psychiatry, 13, 23–49.Google Scholar
Davis, K. L. Mohs, R. Tinklenberg, J. R. Pfefferbaum, A. Hollister, L. E. & Kopell, B. S. (1978) Physostigmine: improvement of long term memory processes in normal humans. Science, 201, 272–273.CrossRefGoogle ScholarPubMed
Deutsch, J. A. (1971) The cholinergic synapse and the site of memory. Science, 174, 788–794.Google Scholar
Deutsch, J. A. (1979) Physiology of acetylcholine in learning and memory. In: Nutrition and The Brain, vol. 5 (eds. Barbeau, A. Growdon, J. H. and Wurtman, R. J.), pp 343–350. New York: Raven Press.Google Scholar
Drachman, D. (1977) Memory and cognitive function in man: does the cholinergic system have a specific role? Neurology, 27, 783–790.Google Scholar
Drachman, D. & Leavitt, J. (1974) Human memory and the cholinergic system: a relationship to aging. Archives of Neurology, 15, 52–61.Google Scholar
Drachman, D. & Sahakian, B. J. (1979) Effect of cholinergic agents on human learning and memory. In: Nutrition and The Brain, vol. 5 (eds. Barbeau, A. Growdon, J. H. and Wurtman, R. J.), pp 351–366. New York: Raven Press.Google Scholar
Etienne, P. Gauthier, S. Johnson, G. Collier, B. Mendis, T. Dastoor, D. Cole, M. & Muller, H. F. (1978) Clinical effects of choline in Alzheimer's disease. The Lancet, i, 508–509.Google Scholar
Glen, A. I. M. & Christie, J. E. (1979) Early diagnosis of Alzheimer's disease: working definitions for clinical and laboratory criteria. In: Alzheimer's Disease: Early Recognition of Potentially Reversible Deficits (eds. Glen, A. I. M. and Whalley, L. J.), pp 122–128. Edinburgh: Churchill Livingstone.Google Scholar
Mohs, R. C. & Davis, K. L. (1979) Cholinomimetic drug effects on memory in young and elderly adults. In: Alzheimer's Disease: Early Recognition of Potentially Reversible Deficits (eds. Glen, A. I. M. and Whalley, L. J.), pp 154–158. Edinburgh: Churchill Livingstone.Google Scholar
Ostfeld, A. & Aruguete, A. (1962) Central nervous system effects of hyoscine in man. Journal of Pharmacology and Experimental Therapeutics, 137, 133–139.Google Scholar
Perry, E. K. Gibson, P. H. Blessed, G. Perry, R. H. & Tomlinson, B. E. (1977) Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyl-transferase and glutamic acid decarboxylase activities in necropsy brain tissue. Journal of the Neurological Sciences, 34, 247–265.Google Scholar
Perry, E. K. Tomlinson, B. E. Blessed, G. Bergmann, K. Gibson, P. H. & Perry, R. H. (1978) Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. British Medical Journal, ii, 1457–1459.Google Scholar
Petersen, R. (1977) Scopolamine induced learning failures in man. Psychopharmacology, 52, 283–289.Google Scholar
Shepard, R. N. (1967) Recognition memory for words, sentences and pictures. Journal of Verbal Learning Behaviour, 6, 156–163.Google Scholar
Signoret, J. L. Whiteley, A. & Lhermitte, F. (1978) Influence of choline on amnesia in early Alzheimer's disease. The Lancet, ii, 837.Google Scholar
Sitaram, N. Weingartner, H. & Gelling, J. C. (1978a) Human serial learning: enhancement with arecoline and choline and impairment with scopolamine. Science, 201, 274.Google Scholar
Sitaram, N. Weingartner, H. Calne, E. & Gilling, J. C. (1978b) Choline: selective enhancement of serial learning and encoding of low imagery words in man. Life Science, 22, 1555.CrossRefGoogle ScholarPubMed
Smith, C. M. & Swash, M. (1978) Possible biochemical basis of memory disorder in Alzheimer's disease. Annals of Neurology, 3, 471–473.Google Scholar
White, P. Goodhardt, M. J. Keet, J. P. Hiley, C. R. Carrasco, L. H. Williams, I. E. I. & Bowen, D. M. (1977) Neocortical cholinergic neurons in elderly people. The Lancet, i, 668–670.Google Scholar
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