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Phenomenology

Its Place in Schizophrenia Research

Published online by Cambridge University Press:  02 January 2018

Ann M. Mortimer*
Affiliation:
Charing Cross & Westminster Medical School, c/o St Bernard's Wing, Ealing Hospital, Uxbridge Road, Southall, Middlesex UB1 3EU

Extract

In some quarters schizophrenia has gained the reputation of a graveyard of research. Few findings stand the test of time, most of the pieces of this particular jigsaw seem to be missing, and it is not easy to make sense of those that are available. Even ‘hard’ scientific findings fail to be replicated, an example being the status of D2 receptors in drug-naive schizophrenics (Wong et al, 1986; Farde et al, 1987).

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Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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References

Andreasen, N. C. (1982) Negative symptoms in schizophrenia: definition and reliability. Archives of General Psychiatry, 39, 784788.Google Scholar
Andreasen, N. C. (1989) Neural mechanisms of negative symptoms. British Journal of Psychiatry, 155 (suppl. 7): 9398.Google Scholar
Bellak, L. (1979) Schizophrenic syndrome related to minimal brain dysfunction: a possible neurologic subgroup. Schizophrenia Bulletin, 5, 480489.Google Scholar
Bilder, R. M., Mukherjee, S., Rieder, M. D., et al (1985) Symptomatic and neuropsychological components of defect states. Schizophrenia Bulletin, 11, 409417.Google Scholar
Brockington, I. F., Kendell, R. E. & Leff, J. P. (1978) Definitions of schizophrenia: concordance and prediction of outcome. Psychological Medicine, 8, 387398.Google Scholar
Carpenter, W. T. (1989) Dissecting Schizophrenia through Psychopathology. Monograph, The 1989 Charles Burlingame, M.D., Award Lecture. Hartford, CT: The Institute of Living.Google Scholar
Ceulemans, D. L. S., Gelders, Y. G., Hoppenbrouwers, M.-L. J. A., et al (1985) Effect of serotonin antagonism in schizophrenia: a pilot study with septoperone. Psychopharmacology, 85, 329332.Google Scholar
Cornblatt, B. A., Lenzenweger, M. F., Dworkin, R. H., et al (1985) Positive and negative schizophrenic symptoms, attention, and information processing. Schizophrenia Bulletin, 11, 397408.Google Scholar
Crow, T. J. (1989) A current view of the Type II Syndrome: age of onset, intellectual impairment, and the meaning of structural changes in the brain. British Journal of Psychiatry, 155 (suppl. 7): 1520.Google Scholar
Cutting, J. (1985) The Psychology of Schizophrenia Chapter 3. Edinburgh: Churchill Livingstone.Google Scholar
Deakin, J. F. W., Slater, P., Simpson, M. D. C., et al (1989) Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. Journal of Neurochemistry, 52, 17811786.Google Scholar
Elliott, F. A. (1982) Neurological findings in adult minimal brain dysfunction and the dyscontrol syndrome. Journal of Nervous and Mental Disease, 170, 680687.Google Scholar
Farde, L., Wiesel, F.-A., Hall, H., et al (1987) No D2 receptor increase in PET study of schizophrenia. Archives of General Psychiatry, 44, 671672.Google Scholar
Frith, C. D. (1987) The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychological Medicine, 17, 631648.Google Scholar
Hertzig, M. E. & Birch, H. G. (1966) Neurologic organization in psychiatrically disturbed adolescent girls. Archives of General Psychiatry, 15, 590598.Google Scholar
Hane, J. A. & Mayerhoff, D. (1989) Do negative symptoms respond to pharmacological treatment? British Journal of Psychiatry, 155 (suppl. 7): 115118.Google Scholar
Haddle, P. F. (1987a) Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychological Medicine, 17, 4957.Google Scholar
Haddle, P. F. (1987b) The syndromes of chronic schizophrenia – a re-examination of the positive-negative dichotomy. British Journal of Psychiatry, 151, 145151.Google Scholar
Haddle, P. F. & Barnes, T. R. E. (1990) Syndromes of chronic schizophrenia. British Journal of Psychiatry, 157, 558561.Google Scholar
McKenna, P. J. (1987) Pathology, phenomenology and the dopamine hypothesis of schizophrenia. British Journal of Psychiatry, 151, 288301.Google Scholar
McKenna, P. J., Tamlyn, D., Hammond, S., et al (1990) Amnesic syndrome in schizophrenia. Psychological Medicine, 20, 967972.CrossRefGoogle ScholarPubMed
Morice, R. (1990) Cognitive inflexibility and pre-frontal dysfunction in schizophrenia and mania. British Journal of Psychiatry, 157, 5054.Google Scholar
Morrison, R. L., Bellack, A. S., Wixted, J. T., et al (1990) Positive and negative symptoms in schizophrenia – a cluster analytic approach. Journal of Nervous and Mental Disease, 178, 377384.Google Scholar
Mortimer, A. M., Lund, C. E. & McKenna, P. J. (1990) The positive: negative dichotomy in schizophrenia. British Journal of Psychiatry 157, 4149.Google Scholar
Owens, D. G. C. & Johnstone, E. C. (1980) The disabilities of chronic schizophrenia – their nature and the factors contributing to their development. British Journal of Psychiatry, 136, 384395.Google Scholar
Owens, D. G. C., Johnstone, E. C., Crow, T. J., et al (1985) Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychological Medicine, 15, 2741.Google Scholar
Pogue-Geile, M. F. (1989) The prognostic significance of negative symptoms in schizophrenia. British Journal of Psychiatry, 155 (suppl. 7): 123127.Google Scholar
Pogue-Geile, M. F. & Harrow, M. (1985) Negative symptoms in schizophrenia: their longitudinal course and prognostic significance. Schizophrenia Bulletin, 11, 427439.Google Scholar
van Praag, H. M., Asnis, G. M., Kahn, R. S., et al (1990) Monoamines and abnormal behaviour. A multi-aminergic perspective. British Journal of Psychiatry, 157, 723734.Google Scholar
Quitkin, F., Rifkin, A. & Klein, D. F. (1976) Neurologic soft signs in schizophrenia and character disorders. Archives of General Psychiatry, 33, 845853.Google Scholar
Reyntjens, A. J. M., Gelders, Y. G., Hoppenbrouers, M.-L. J. A., et al (1986) Thymosthenic effects of ritsanterin (R 55 667), a centrally acting serotonin-S2 receptor blocker. Drug Development and Research, 8, 205211.Google Scholar
Rogers, D. (1987) Neuropsychiatry. British Journal of Psychiatry, 150, 425427.Google Scholar
Shallice, T., Burgess, P. W. & Frith, C. D. (1991) Can the neuropsychological case-study approach be applied to schizophrenia? Psychological Medicine, 21, 661675.Google Scholar
Simpson, M. D. C., Slater, P., Deakin, J. F. W., et al (1989) Reduced GABA uptake sites in the temporal lobe in schizophrenia. Neuroscience Letters, 107, 211215.Google Scholar
Sims, A. C. P. (1988) Symptoms in the Mind, pp. 159161. London: Baillière Tindall.Google Scholar
Tamlyn, D., McKenna, P. J., Mortimer, A. M., et al (1992) Memory impairment in schizophrenia – its extent, affiliations and neuropsychological character. Psychological Medicine, 22, 101105.Google Scholar
Tsuang, M. T., Lyons, M. J. & Faraone, S. V. (1990) Heterogeneity of schizophrenia. Conceptual models and analytic strategies. British Journal of Psychiatry, 156, 1726.Google Scholar
Wing, J. K. & Brown, G. W. (1970) Institutionalism and Schizophrenia. Cambridge: Cambridge University Press.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974a) The Measurement and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974b) The Present State Examination. Cambridge: Cambridge University Press.Google Scholar
Wong, D. F., Wagner, H. N., Tune, L. E., et al (1986) Positron emission tomography reveals elevated D-2 dopamine receptors in drug-naive schizophrenics. Science, 234, 15581563.Google Scholar
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