Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-05T07:00:21.566Z Has data issue: false hasContentIssue false

Panic Attacks: New Approaches to an Old Problem

Published online by Cambridge University Press:  29 January 2018

M. G. Gelder*
Affiliation:
Warneford Hospital, Oxford OX3 7JX

Abstract

Anxiety attacks were included in the first descriptions of the syndrome of anxiety neurosis. Recently it has been suggested that such attacks (now usually called panic attacks) characterize a distinct form of anxiety disorder—panic disorder, it has also been proposed that panic attacks result from a biochemical disorder and require pharmacological treatment. Some of the evidence for these ideas is presented, and two other explanations for panic attacks are reviewed: that they are caused by hyperventilation, and that they result from a cognitive disorder. It is concluded that although it is not possible on the present evidence to choose between the three theories, there is strong indirect support for the cognitive theory and good reason to investigate cognitive factors more thoroughly. Future work on biochemical causes of, and pharmacological treatments for panic attacks should take account of such factors.

Type
Papers
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd ed.) (DSM–III). Washington DC: APA.Google Scholar
American Psychiatric Association (1985) DSM–III–R in Development. Washington DC: APA.Google Scholar
Anderson, D. J., Noyes, R. & Crowe, R. R. (1984) The comparison of panic disorder and generalized anxiety disorder. American Journal of Psychiatry, 141, 572575.Google Scholar
Beck, A. T., Laude, R. & Bohnert, M. (1974) Ideational components of anxiety neuroses. Archives of General Psychiatry, 31, 319325.Google Scholar
Boulenger, J. P., Uhde, T. W., Wolfe, E. A. & Post, R. M. (1984) Increased sensitivity to caffeine in patients with panic disorders. Archives of General Psychiatry, 41, 10671071.CrossRefGoogle ScholarPubMed
Charney, D. S. & Heninger, G. R. (1985) Noradrenergic function and the mechanism of anti-anxiety treatment: II. The effect of long-term imipramine treatment. Archives of General Psychiatry, 42, 473481.CrossRefGoogle Scholar
Charney, D. S., Menkes, D. B. & Heninger, G. R. (1981) Receptor sensitivity and the mechanism of action of antidepressant treatment: implications for the etiology and therapy of depression. Archives of General Psychiatry, 38, 11601180.Google Scholar
Charney, D. S., Heninger, G. R. & Breier, A. (1984) Noradrenergic function in panic anxiety. Archives of General Psychiatry, 41, 751762.CrossRefGoogle ScholarPubMed
Clark, C. M., & Hemsley, D. R. (1982) Effects of hyperventilation: individual variability and its relation to personality. Journal of Behaviour Therapy and Experimental Psychiatry, 13, 4147.Google Scholar
Clark, C. M., Salkovskis, P. M. & Chalkley, A. J. (1985) Respiratory control as a treatment for panic attack. Journal of Behaviour Therapy and Experimental Psychiatry, 16, 2330.CrossRefGoogle Scholar
Clutton-Brock, T. H. & Rithalia, S. V. S. (1984) Transcutaneous carbon dioxide monitoring. British Journal of Hospital Medicine, 31, 225229.Google ScholarPubMed
Cowen, P. J., Green, A. R., Grahame-Smith, D. G. & Braddock, L. E. (1985) Plasma melatonin during desmethylimipramine treatment: evidence for changes in noradrenergenic transmission. British Journal of Clinical Pharmacology, 19, 799805.CrossRefGoogle ScholarPubMed
Crowe, R. R., Noyes, R., Pauls, D. L. & Slymen, D. (1983) A family study of panic disorder. Archives of General Psychiatry, 40, 10651069.Google Scholar
da Costa, J. M. (1871) Irritable heart; the clinical study of the form of functional cardiac disorder and its consequences. American Journal of Medical Sciences, 71, 1752.Google Scholar
Fraser, S. & Wilson, R. M. (1918) The sympathetic nervous system—the “irritable heart of soldiers”. British Medical Journal, 2, 2729.Google Scholar
Freud, S. (1895) The justification for detaching from neurasthenia a particular syndrome: the anxiety-neurosis. Neurologisches Zentralblatt, 2. Reprinted (1940) in Collected Papers, 1 (trans. Riviere, J.), 76106.Google Scholar
Garakani, H., Zitrin, C. M. & Klein, D. F. (1984) Treatment of panic disorder with imipramine alone. American Journal of Psychiatry, 141, 446448.Google Scholar
Grant, S. J., Huang, Y. H. & Redmond, D. E. (1980) Benzodiazepines attenuate single unit activity in the locus ceruleus. Life Sciences, 27, 22312236.Google Scholar
Hibbert, G. A. (1985) Ideational components of anxiety, their origin and content. British Journal of Psychiatry, 144, 618624.Google Scholar
Hibbert, G. A. (1986) The diagnosis of hyperventilation using ambulatory carbon dioxide monitoring. Proceedings of the 15th European Conference for Psychosomatic Research (eds. Lacey, H. & Sturgeon, J.). London: John Libby.Google Scholar
Hibbert, G. A. & Chan, M. (1986) Respiratory control: its contribution to the treatment of panic attacks—a controlled study. In press.Google Scholar
Hoehn-Saric, R. (1982) Comparison of generalized anxiety disorder with panic disorder patients. Psychopharmacology Bulletin, 18, 104108.Google Scholar
Hume, W. E. (1918) A study of the cardiac disabilities of soldiers in France (V.D.H. & D.A.H.) The Lancet, i, 529534.Google Scholar
Klein, D. F. (1964) Deliniation of two drug-responsive anxiety syndromes. Psychopharmacologia, 5, 397408.Google Scholar
Ko, G. N., Elsworth, J. D., Roth, R. H., Rifkin, B. G., Leigh, H. & Redmond, E. (1983) Panic induced elevation of plasma MHPG levels in phobic-anxious patients. Archives of General Psychiatry, 40, 425430.Google Scholar
Lader, M. & Mathews, S. (1970) Physiological changes during spontaneous panic attacks. Journal of Psychosomatic Research, 14, 377382.Google Scholar
Lewis, B. I. (1954) Chronic hyperventilation syndrome. Journal of the American Medical Association, 155, 12041208.Google Scholar
Nesse, R. M., Cameron, O. G., Curtis, G. C., McCann, D. S. & Huber-Smith, M. J. (1984) Adrenergic function in patients with panic anxiety. Archives of General Psychiatry, 41, 771776.Google Scholar
Pitts, F. M. & McClure, J. N. (1967) Lactate metabolism in anxiety neurosis. New England Journal of Medicine, 277, 13291336.Google Scholar
Raskin, M., Peeke, H. B. S., Dickman, W. & Pinsker, H. (1982) Panic and generalized anxiety disorder. Archives of General Psychiatry, 39, 687689.Google Scholar
Redmond, D. E. & Huang, Y. H. (1982) The primate locus ceruleus and effects of Clonidine on opiate withdrawal. Journal of Clinical Psychiatry, 43, 2529.Google Scholar
Salkovskis, P. M., Jones, D. R. O. & Clark, D. M. (1985) Respiratory control in the treatment of panic attacks: replication and extention with concurrent measurement of behaviour and pCO2 . British Journal of Psychiatry, 148, 526532.Google Scholar
Sanghera, M. K., McMillen, B. A. & German, D. C. (1983) Buspirone, a norbenzodiazepine anxiolytic, increases locus coeruleus noradrenergic neuronal activity. European Journal of Pharmacology, 86, 107110.Google Scholar
Wearn, J. T. & Sturgis, C. C. (1919) Studies in epinephrin: I. Effects of injection of epinephrin in soldiers with “irritable heart”. Archives of Internal Medicine, 24, 247268.CrossRefGoogle Scholar
Wood, R. (1941) da Costa's Syndrome (or Effort Syndrome). British Medical Journal, 1, 767774, 805–811, and 846–851.CrossRefGoogle ScholarPubMed
Zitrin, C. M. (1983) Differential treatment for phobias: use of imipramine for panic attacks. Journal of Behaviour Therapy and Experimental Psychiatry, 14, 1118.Google Scholar
Zitrin, C. M., Klein, D. F. & Woerner, M. G. (1978) Behaviour therapy, supportive psychotherapy, imipramine and phobias. Archives of General Psychiatry, 35, 307316.Google Scholar
Zitrin, C. M., Klein, D. F., Woerner, M. G. & Ross, D. C. (1983) Treatment of phobias: I. Comparison of imipramine hydrochloride and placebo. Archives of General Psychiatry, 40, 125138.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.