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High Dose Flupenthixol Decanoate in Chronic Schizophrenia

Published online by Cambridge University Press:  29 January 2018

R. G. McCreadie ,
W. L. Flanagan ,
J. McKnight  and
A. Jorgensen
R. G. McCreadie
Affiliation:
Crichton Royal Hospital, Dumfries (Gartnavel Royal Hospital, Glasgow)
J. McKnight
Affiliation:
Gartnavel Royal Hospital, Glasgow G12 0XH
A. Jorgensen
Affiliation:
H. Lundbeck & Co., A/S Copenhagen, Denmark
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Summary

In a double-blind trial, female ‘drug-resistant’ chronic schizophrenic in-patients were given high dose or standard dose flupenthixol decanoate for 13 weeks. Plasma flupenthixol levels showed a five-fold interindividual variation, but were consistently higher with the high dose. Analysis of final scores showed no statistically significant differences between groups with regards to mental state, ward behaviour and extrapyramidal side-effects. When compared with pre-trial scores, the extrapyramidal side-effects worsened significantly in the high dose patients and social withdrawal decreased in the standard dose patients. The mental state of a sub-group of patients, possibly drug resistant for pharmacokinetic reasons, improved significantly on the high dose over the 13 weeks.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 135 , Issue 2 , August 1979 , pp. 175 - 179
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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