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Enhanced Relief of Phobias by Flooding During Waning Diazepam Effect

Published online by Cambridge University Press:  29 January 2018

I. M. Marks
Affiliation:
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, S.E.5
R. Viswanathan
Affiliation:
Moorhaven Hospital, Ivybridge, Devon
M. S. Lipsedge
Affiliation:
St. Bartholomew's Hospital, London, E.C.1
R. Gardner
Affiliation:
Bethlem Royal and Maudsley Hospitals, Denmark Hill, London, S.E.5

Extract

Sedatives such as barbiturates, benzodiazepines and alcohol are valuable reducers of anxiety, but their effects do not endure for long after the drug has been metabolized and excreted. Phobics often become able to enter their phobic situation under the influence of sedatives, but as the drug effect wears off they begin to escape from the situation once more. This might be a form of drug-dissociative behaviour. In animal experiments, behaviour learned in the sedative drugged state often fails to transfer to the undrugged state (Miller, 1964). However, this effect might be more pronounced during the phase of peak drug effect than during the phase when the drug effect is wearing off. In rats, exposure to the phobic situation during slow withdrawal of sedative drugs was found to be effective in extinguishing conditioned avoidance responses (Sherman, 1967). That more lasting behavioural changes can follow treatment given both in the drug and in the non-drug state is suggested by evidence adduced by Baum (1971); he found that, in rats, avoidance behaviour which was learned both in the alcohol and in the non-drug state was more resistant to extinction than avoidance acquired in a non-drug state alone. The same might apply to approach behaviour in human phobics.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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References

Baum, M. (1971). ‘Avoidance training in both alcohol and non-drug states increases the resistance-to-extinction of an avoidance response in rats.’ Psychopharmacologia, 19, 8790.CrossRefGoogle ScholarPubMed
Besser, G. M. (1967). Some physiological characteristics of auditory flutter fusion in man.’ Nature, 214, 428.CrossRefGoogle ScholarPubMed
Friedman, D. E., and Lipsedoe, M. S. (1971). ‘Treatment of phobic anxiety and psychogenic importance by systematic desensitization employing methohexitone-induced relaxation.’ Brit. J. Psychiat., 118, 8790.Google Scholar
Gelder, M. G., and Marks, I. M. (1966). ‘Severe agoraphobia: a controlled prospective trial of behaviour therapy.’ Brit. J. Psychiat., 112, 309–19.CrossRefGoogle ScholarPubMed
King, A., and Little, J. G. (1959). ‘Thiopentone treatment of the phobic-anxiety-depersonalization syndrome.’ Proc. Roy. Soc. Med., 52, 595–6.Google ScholarPubMed
Lang, P. J. (1969). ‘The mechanics of desensitization and the laboratory study of human fear’, in Behaviour Therapy (ed. C. M. Franks). McGraw-Hill.Google Scholar
Marks, I. M. (1965). ‘Patterns of meaning in psychiatric patients.’ Maudsley Monograph No. 13. Oxford University Press.Google Scholar
Marks, I. M. (1969). Fears and Phobias. London: Heinemann Medical.Google Scholar
Marks, I. M., and Sartorius, N. H. (1968). ‘A contribution to the measurement of sexual attitude.’ J. new. ment. Dis., 145, 441–51.Google Scholar
Marks, I. M., Marset, P., Boulouoouris, J., and Huson, J. (1971a). ‘Physiological accompaniments of neutral and phobic imagery.’ Psychological Medicine, 1, 299307.CrossRefGoogle ScholarPubMed
Marks, I. M., Boulouoouris, J., and Marset, P. (1971b). ‘Flooding and densensitization in the treatment of phobic patients.’ Brit. J. Psychiat., 119, 353–75.CrossRefGoogle Scholar
Mathews, A., and Lader, M. (1972). ‘An evaluation of forearm blood flow as a psychophysiological measure.’ Awaiting publication.Google Scholar
Mawson, A. B. (1971). ‘Methohexitone-assisted desensitization in treatment of phobias.’ Lancet, i, 1084–6.Google Scholar
McCormick, W. O., and O'Gorman, E. (1971). ‘Dedining dose drug desensitization.’ Paper to Conference on Behaviour Therapy, Munich, July.Google Scholar
Miller, N. E. (1964). In Animal Behaviour and Drug Action (ed. H. Steinberg). London: Churchill.Google Scholar
Sherman, A. R. (1967). ‘Therapy of maladaptive fear-motivated behaviour in the rat by the systematic gradual withdrawal of a fear-reducing drug.’ Behav. Res. and Ther., 5, 121–9.CrossRefGoogle ScholarPubMed
Watson, J. P., Gaind, R., and Marks, I. M. (1971). ‘Prolonged exposure: a rapid treatment for phobias.’ Brit. med. J., i, 1315.CrossRefGoogle ScholarPubMed
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