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Demethylation of C14 2,3,4-Trimethoxyphenylethylamine in Schizophrenics Before and After L-methionine Loading

Published online by Cambridge University Press:  29 January 2018

F. T. Antun  and
R. Kurkjian
F. T. Antun
Affiliation:
American University Medical Centre, PO Box 113-6044, Beirut, Lebanon
R. Kurkjian
Affiliation:
Brain Metabolism Unit, Department of Internal Medicine, American University Medical Centre, Beirut, Lebanon
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Summary

Demethylation was compared in acute and chronic schizophrenics and in non-schizophrenics by the administration of C14 labelled 2,3,4-trimethoxyphenylethylamine (TMPEA). The results did not show a significant difference in the urinary levels of the monodemethylated catabolites of TMPEA among any groups of patients. However, there was a significant decrease in demethylation in untreated chronic schizophrenics after ten days of L-methionine orally, whereas the non-schizophrenic group similarly given methionine did not change. This suggests the possibility of a biological weakness in schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 140 , Issue 6 , June 1982 , pp. 611 - 614
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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References

Alexander, F., Curtis, G. C., Sprince, H. & Crosley, A. P. J. (1963) L-methionine and L-tryptophane feedings in non-psychotic and schizophrenic patients with and without tranylcypromine. Journal of Nervous and Mental Disease, 137, 135–42.Google Scholar
Antun, F. T., Burnett, G. B., Cooper, A. J., Daly, R. J., Smythies, J. R. & Zealley, A. K. (1971a) The effects of L-methionine without MAOI in schizophrenia. Journal of Psychiatric Research, 8, 63–71.Google Scholar
Antun, F. T., Smythies, J. R., Benington, F., Morin, R. D., Berknecht, C. F. & Nichols, D. E. (1971) Native fluorescence and hallucinogenic potency of some amphetamines. Experientia, 27, 62–3.CrossRefGoogle ScholarPubMed
Axelrod, J. (1959) Metabolism of epinephrine and other sympathomimetic amines. Physiological Reviews, 39, 751–76.Google Scholar
Brossi, A. & Teitel, S. (1969) 4-Desmethyl mescaline. Organic Preparations and Procedures, 3, 171–2.Google Scholar
Brune, G. C. & Himwich, H. E. (1962) Effects of L-methionine loading on the behaviour of schizophrenic patients. Journal of Nervous and Mental Disease, 137, 447–50.Google Scholar
Duff, J. C. (1941) A general method for the synthesis of O-hydroxy aldehydes from phenols and hexamethylenetetramine. Journal of the Chemical Society, 547–51.Google Scholar
Israelstam, D. M., Sargent, T., Finley, N. N., Winchell, H. S., Fish, M. B., Pollycone, M. & Johnson, A. (1970) Abnormal methionine metabolism in schizophrenic and depressive states. Journal of Psychiatric Research, 7, 185–9.Google Scholar
Kakimoto, Y., Sano, I., Kanazawa, A., Tsujio, T. & Kanelo, Z. (1967) Metabolic effects of methionine in schizophrenics pretreated with MAOI. Nature, 216, 1110–11.Google Scholar
Kubota, L. S. & Masui, T. (1965) The structure and synthesis of takatonine. Tetrahedron Letters, 40, 3599–602.Google Scholar
Meister, A. (1965) Biochemistry of Aminoacids, Vol 2, 2nd Edition. New York: Academic Press Google Scholar
Osmond, H. & Smythies, J. R. (1952) Schizophrenia: A new approach. Journal of Mental Science, 98, 309–15.Google Scholar
Pollin, W., Cardon, P. V. Jr. & Kety, S. S. (1961) Effects of amino acid feeding in schizophrenic patients treated with iproniazid. Science, 133, 104–5.CrossRefGoogle ScholarPubMed
Shulgin, A. T., Sargent, T. & Naranjo, C. (1969) Structure-activity relationship studies of one ring psychotomimetics. Nature, 221, 537–41.Google Scholar
Slotta, K. H. & Muller, J. (1936) The breakdown of mescaline and substances similar to mescaline in the organism (trans). Hoppe-Seyler's Zeitschrift für Physiologische Chemie, 238, 14–19.Google Scholar
Smythies, J. R., Bradley, R. J. & Johnson, V. S. (1967) Structure-activity relationships studies on mescaline. Psychopharmacologia, 10, 379.Google Scholar
Worral, D. E. (1941) Organic Syntheses Collective, Vol 1. 2nd ed. New York: John Wiley. 413–14.Google Scholar
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