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Cyclic Amp Levels in Blood Cells from a Short-Cycle Manic-Depressive Subject

Published online by Cambridge University Press:  29 January 2018

Dorothy E. Buckley ,
Graham J. Naylor ,
David A. Stansfield  and
Richard A. Brown
Dorothy E. Buckley
Affiliation:
Department of Psychiatry/Biochemistry, University of Dundee, Royal Dundee Liff Hospital, Dundee DD2 5NF
Graham J. Naylor
Affiliation:
Department of Psychiatry, Ninewells Hospital and Medical School, Dundee DD1 9SY
David A. Stansfield
Affiliation:
Department of Biochemistry, University of Dundee
Richard A. Brown
Affiliation:
Department of Mathematics, University of Dundee
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Summary

Erythrocyte and leucocyte numbers and cyclic AMP content were monitored weekly in a mentally defective short-cycle manic-depressive woman. The erythrocyte count remained relatively constant but cyclic AMP content when manic was significantly higher than when depressed, and the mood and biochemical data appeared to have the same periodicity, with coincident peaks and troughs. Total leucocytes were related to mood, with peaks in the manic phase. Mononuclear cyclic AMP content varied without relation to manic or depressive phases.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 136 , Issue 6 , June 1980 , pp. 584 - 590
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Abdulla, Y. H. & Hamadah, K. (1970) 3′5’ Cyclic adenosine monophosphate in depression and mania. Lancet, i, 378–81.Google Scholar
Bain, B. J. & England, J. M. (1975) Variations in leucocyte count during menstrual cycle. British Medical Journal, ii, 473–5.Google Scholar
Bourne, H. R., Lichtenstein, L. M., Melmon, K. L., Henney, C. S., Weinstein, Y. & Shearer, G. M. (1974) Modulation of inflammation and immunity of cyclic AMP. Science, 184, 19–28.CrossRefGoogle Scholar
Bøyum, A. (1968) Separation of leucocytes from blood and bone marrow. Scandinavian Journal of Clinical Laboratory Investigations, 21, Suppl. 97.Google Scholar
Broadus, A. E., Kaminsky, N. I., Hardman, J. G., Sutherland, E. W. & Liddle, G. W. (1970a) Kinetic parameters and renal clearances of plasma adenosine 3′5’ monophosphate and guanosine 3′5’ monophosphate in man. Journal of Clinical Investigation, 49, 2222–36.CrossRefGoogle ScholarPubMed
Broadus, A. E., Kaminsky, N. I., Northcott, R. G., Hardman, J. G., Sutherland, , & Liddle, G. W. (1970b) Effects of glucagon on adenosine 3′5’ monophosphate and guanosine 3′5’ monophosphate in human plasma and urine. Journal of Clinical Investigation, 49, 2237–45.Google Scholar
Brown, B. L., Salway, J. G., Albano, J. D. M., Hullin, R. P. & Ekins, R. P. (1972) Urinary excretion of cyclic AMP and manic depressive psychosis. British Journal of Psychiatry, 120, 405–8.Google Scholar
Hansen, O. (1972) Blood nucleoside and nucleotide studies in mental disease. British Journal of Psychiatry, 121, 341–50.Google Scholar
Hullin, R. P., Salway, J. G., Allsopp, M. N. E., Barnes, G. D., Albano, J. D. M. & Brown, B. L. (1974) Urinary cyclic AMP in the switch process from depression to mania. British Journal of Psychiatry, 125, 457–8.Google Scholar
Jarrett, D. B., Newell, B., Davies, B. & Coghlan, J. P. (1977) Adenosine 3′5’ cyclic monophosphate metabolism in patients with severe depressive illness. Psychological Medicine, 7, 93–101.Google Scholar
Jenner, F. A., Sampson, G. A., Thompson, E. A., Somerville, A. R., Beard, N. A. & Smith, A. A. (1972) Manic-depressive psychosis and urinary excretion of cyclic AMP. British Journal of Psychiatry, 121, 236–7.Google Scholar
Kaiser, G., Quiring, K., Gauger, D., Palm, D., Becker, H. & Schoeppe, W. (1974) Occurrence of adenyl cyclase activity in human erythrocytes. Blut, 29, 115–22.CrossRefGoogle ScholarPubMed
Kemp, B. E., Froscio, M., Rogers, A. & Murray, A. W. (1975) Multiple protein kinases from human lymphocytes. Biochemical Journal, 145, 241–9.Google Scholar
McDonald, J. W. D. (1971) Lymphocyte and platelet adenyl cyclase. Canadian Journal of Biochemistry, 49, 316–19.Google Scholar
Naylor, G. J., Stansfield, D. A., Whyte, S. F. & Hutchison, F. (1974) Urinary excretion of adenosine 3′5’ cyclic monophosphate in depressive illness. British Journal of Psychiatry, 125, 275–9.Google Scholar
Naylor, G. J., Buckley, D., Reid, A. H. & Stansfield, D. A. (1975) Whole blood cyclic AMP levels in a short-cycle manic depressive. IRCS Medical Science Metabolism and Nutrition; Psychiatry and Clinical Psychology, 3, 278.Google Scholar
Paul, M. J., Ditzion, B. R., Pauk, G. L. & Janowsky, D. S. (1970) Urinary adenosine 3′5’ monophosphate excretion in affective disorders. American Journal of Psychiatry, 126 (10), 1493–9.CrossRefGoogle ScholarPubMed
Paul, I. M., Cramer, H. & Bunney, W. E. (1971) Urinary cAMP in the switch process from depression to mania. Science, 171, 300–3.Google Scholar
Post, R. M., Cramer, H. & Goodwin, F. K. (1977) Cyclic AMP in cerebrospinal fluid of manic and depressive patients. Psychological Medicine, 7, 599–605.Google Scholar
Reid, A. H. & Naylor, G. J. (1976) Short-cycle manic depressive psychosis in mental defectives: A clinical and physiological study. Journal of Mental Deficiency Research, 20, 67.Google Scholar
Robison, G. A., Coppen, A. J., Whybrow, P. C. & Prange, A. J. (1970) Cyclic AMP in affective disorders, Lancet, ii, 1028–9.Google Scholar
Rosen, O. M., Rubin, C. S. & Erlichman, J. (1973) Molecular characterization of cyclic AMP—dependent protein kinases derived from bovine heart and human erythrocytes. In Protein Phosphorylation in Control Mechanism (eds. Huijing, F. and Lee, E. Y. C.,) London: Academic Press, 67–82.Google Scholar
Scott, R. E. (1970) Effects of prostaglandins, epinephrine and NaF on human leucocyte, platelet and liver adenyl cyclase, Blood, 35, 514–16.Google Scholar
Sinanan, K., Keatinge, A. M. B., Becket, P. G. S. & Clayton Love, W. (1975) Urinary cyclic AMP in ‘Endogenous’ and ‘Neurotic’ depression. British Journal of Psychiatry, 126, 49–55.Google Scholar
Smith, C. S., Tallman, J. F., Post, R. M., Van Kammen, D. P., Jimnerson, D. C., Brown, G. L., Brookes, B. R. & Bunney, W. E. Jr. (1976) An examination of baseline and drug-induced levels of cyclic nucleotides in the cerebrospinal fluid of control and psychiatric patients. Life Sciences, 19, 131–6.Google Scholar
Smoake, J. A., Song, S. & Cheung, W. Y. (1974) Cyclic 3′5’ nucleotide phosphodiesterase, distribution and developmental changes of the enzyme and its protein activator in mammalian tissues and cells. Biochemica et Biophysica Acta, 341, 402–11.Google Scholar
Tomlinson, S., Barling, B. M., Albano, J. D. M., Brown, B. L. & O'Riordan, J. L. H. (1974) The effects of exogenous parathyroid hormone on plasma and urinary adenosine 3′5’ cyclic monophosphate in man. Clinical Science and Molecular Medicine, 47, 481–92.Google Scholar
Tsung, P., Salamoto, T. & Weissmann, G. (1975) Protein kinase and phosphates from human polymorphonuclear leucocytes. Biochemical Journal, 145, 437–48.Google Scholar
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