Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-12-01T00:16:22.730Z Has data issue: false hasContentIssue false
  • English
  • Français

Combination Treatment with Noradrenalin and Serotonin Reuptake Inhibitors in Resistant Depression

Published online by Cambridge University Press:  02 January 2018

R. Seth ,
A. L. Jennings ,
J. Bindman ,
J. Phillips  and
K. Bergmann
R. Seth*
Affiliation:
The Maudsley Hospital, Denmark Hill, London SE5 8AZ
K. Bergmann
Affiliation:
Bethlem Royal and Maudsley Hospitals
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

Eight cases of resistant recurrent depression were treated with a combination of nortriptyline and a new serotonin reuptake inhbitor, with or without concurrent lithium therapy. Significant improvement was seen in all patients where other drug regimes and ECT had been ineffective. No adverse reactions occurred in any of our patients, seven of whom were elderly. The combination treatment was more effective than individual therapies alone.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 161 , Issue 4 , October 1992 , pp. 562 - 565
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Asberg, M., Traskman, L. & Thoren, P. (1976) 5HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Archives of General Psychiatry, 33, 1193–1197.CrossRefGoogle ScholarPubMed
Baldwin, R. C. & Jolley, D. J. (1986) The prognosis of depression in old age. British Journal of Psychiatry, 149, 574–583.Google Scholar
Barker, W. A., Scott, J. & Eccleston, D. (1987) The Newcastle chronic depression study: results of a treatment regime. International Clinical Psychopharmacology, 2, 261–272.CrossRefGoogle ScholarPubMed
Bowden, C. L., Koslow, S. H., Hanin, I., et al (1985) Effects of amitriptyline and imipramine on brain amine neurotransmitter metabolites in cerebrospinal fluid. Clinical Pharmacology and Therapeutics, 37, 316–324.CrossRefGoogle ScholarPubMed
Bradley, P. B., Engel, G., Fennik, W., et al (1986) Proposals for the classification and nomenclature of functional receptors for 5–hydroxytryptamine. Neuropharmacology, 25, 563–567.CrossRefGoogle ScholarPubMed
Eccleston, D. & Cole, A. J. (1990) Calcium channel blockade and depressive illness. British Journal of Psychiatry, 156, 889–891.CrossRefGoogle ScholarPubMed
Green, A. R. (1987) Evolving concepts on the interactions between antidepressant treatments and monoamine neurotransmitters. Neuropharmacology, 26, 815–822.CrossRefGoogle ScholarPubMed
Hollander, J. & Burrows, C. H. (1968) Enzymatic studies in senescent rodent brain. Journal of Gerontology, 23, 174–179.Google Scholar
Koe, K. B. (1990) Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin re-uptake. Journal of Clinical Psychiatry, 51, 12 (suppl B).Google Scholar
Moudgil, V. K. & Kanungo, M. S. (1973) Effect of age on the circadian rhythm of acetylcholinesterase of the brain of the rat. Comparative and General Pharmacology, 4, 127–130.Google Scholar
Nordin, C., Bertilsson, L. & Siwers, B. (1987) Clinical and biochemical effects during treatment of depression with nortriptyline: the role of 10–hydroxynortriptyline. Clinical Pharmacology and Therapeutics, 42, 10–19.CrossRefGoogle ScholarPubMed
Post, F. (1972) The management and nature of depressive illness in late life: A follow-through study. British Journal of Psychiatry, 121, 393–404.Google Scholar
Schou, M. (1990) Lithium and treatment resistant depressions: a review. Lithium, 1, 3–8.Google Scholar
Stahl, S. M. & Palazidou, L. (1986) The pharmacology of depression: study of neurotransmitter receptors lead the search for biochemical lesions and new drug therapies. Trends in Pharmacological Sciences, 48, 349–353.CrossRefGoogle Scholar
Sulser, F. (1987) Serotonin-norepinepherine receptor interactions in the brain: implications for the pharmacology and pathophysiology of affective disorders. Journal of Clinical Psychiatry, 48 (suppl.): 12–18.Google Scholar
Thal, L. J., Horowitz, S. G., Dvorkim, B., et al (1980) Evidence for loss of brain 3H-spiroperidol and 3H-ADTN binding sites in rabbit brain with aging. Brain Research, 192, 185–194.Google Scholar
Vetulani, J. & Sulser, F. (1975) Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain. Nature, 257, 495–496.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.