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Combination of behaviour therapy with fluvoxamine in comparison with behaviour therapy and placebo

Results of a multicentre study

Published online by Cambridge University Press:  06 August 2018

F. Hohagen ,
G. Winkelmann ,
H. Rasche-Räuchle ,
I. Hand ,
A. König ,
N. Münchau ,
H. Hiss ,
C. Geiger-Kabisch ,
C. Käppler  and
P. Schramm
...Show all authors
F. Hohagen*
Affiliation:
Department of Psychiatry and Psychotherapy, University of Freiburg
G. Winkelmann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Freiburg
H. Rasche-Räuchle
Affiliation:
Department of Psychiatry and Psychotherapy, University of Freiburg
I. Hand
Affiliation:
Department of Psychiatry, University of Hamburg
A. König
Affiliation:
Department of Psychiatry, University of Hamburg
N. Münchau
Affiliation:
Department of Psychiatry, University of Hamburg
H. Hiss
Affiliation:
Department of Psychiatry, University of Hamburg
C. Geiger-Kabisch
Affiliation:
Central Institute of Mental Health, Mannheim
C. Käppler
Affiliation:
Department of Psychiatry and Psychotherapy, University of Freiburg
P. Schramm
Affiliation:
Department of Psychiatry and Psychotherapy, University of Freiburg
E. Rey
Affiliation:
Central Institute of Mental Health, Mannheim
J. Aldenhoff
Affiliation:
Department of Psychiatry, University of Kiel
M. Berger
Affiliation:
Department of Psychiatry and Psychotherapy, University of Freiburg
*
Correspondence: Dr Fritz Hohagen, Psychiatric Department of the University of Freiburg, Hauptstr. 5, 79104 Freiburg, Germany. Tel: +49 761–270-6521/6518. Fax: +49 761–270-6523
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Abstract

Background We investigated whether the combination of multimodal behaviour therapy (BT) with fluvoxamine is superior to BTand placebo in the acute treatment of severely ill in-patients with obsessive-compulsive disorder (OCD).

Method In a randomised, double-blind design, 30 patients were treated for nine weeks with BT plus placebo and 30 patients with BT plus fluvoxamine (maximum dosage 300 mg, mean dose 288.1 mg). BT included exposure with response prevention, cognitive restructuring and development of alternative behaviours.

Results Both groups showed a highly significant symptom reduction after treatment. There were no significant differences between the groups concerning compulsions. Obsessions were significantly more reduced in the fluvoxamine and BT group than in the placebo and BT group. Furthermore, the group BT plus fluvoxamine showed a significantly higher response rate (87.5 v. 60%) according to a previously defined response criterion. Severely depressed patients with OCD receiving BT plus placebo presented a significantly worse treatment outcome (Y–BOCS scores) than all other groups.

Conclusions The results suggest that BTshould be combined with fluvoxamine when obsessions dominate the clinical picture and when a secondary depression is present.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 173 , Issue S35: New perspectives in research and treatment of obsessive-compulsive disorder , August 1998 , pp. 71 - 78
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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