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Biology of Sexuality Inborn Determinants of Human Sexual Response

Published online by Cambridge University Press:  29 January 2018

Raymond E. Goodman
Raymond E. Goodman*
Affiliation:
Community Health Service, Eccles Health Centre, Corporation Road, Eccles, Manchester, M30 0NJ
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Summary

Opinions vary on the relative importance of biological and learning processes in the aetiology of sexual expression and deviance. The structure of personality, consistency of fantasy patterns, and the familial nature of homosexuality hint at a biological an/age. Research with the HY-antigen complex and X chromosome, and the elucidation of the interactions of intrauterine testosterone and its products with the foetal brain and neurotransmitters, have given us new models to understand the programming of sexuality. However, gonadotrophin feedback is not relevant as an indicator of brain feminization in primates and man. Finally, the interaction of masculinization and defeminization provides us with a model for understanding homosexual behaviour.

Type
Symposium on Sexual Deviation
Information
The British Journal of Psychiatry , Volume 143 , Issue 3 , September 1983 , pp. 216 - 220
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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References

Anderson, D. C. (1981) Physiology of human fetal sex differentiation. In Clinical Paediatric Endocrinology (ed. Brooke, C. S. D.). Oxford: Blackwell Scientific Publications.Google Scholar
Anonymous (1981) Opportunistic infections and Kaposi's sarcoma in homosexual men. New England Journal of Medicine. 305, 1439–44.Google Scholar
Arnold, A. P. (1980) Sexual differences in the brain. American Science, 68, 165–73.Google ScholarPubMed
Baker, S. W. (1980) Psychosexual differentiation in the human. Biology of Reproduction, 22, 61–72.Google Scholar
Bancroft, J. (1974) Deviant Sexual Behaviour: Modification and Assessment, 1–20. London: Oxford University Press.Google Scholar
Baum, M. J. (1979) Differentiation of coital behaviour in mammals: a comparative analysis. Neuroscience and Biobehavioural Review, 3, 265–84.Google Scholar
Bidling Maier, F., Knorr, D. & Neuman, F. (1977) Inhibition of masculine differentiation in male offspring of rabbits actively immunised against testosterone before pregnancy. Nature, 266, 647–8.Google Scholar
Brandon, S. (1979) Aspects of psychosexual problems. Paper given to a symposium organized by the Department of Psychiatry, University of Liverpool.Google Scholar
de Sade, , Marquis, (1785) 120 Days of Sodom and Other Writings. (Compiled and translated in 1966 by Wainhouse, A. and Seaver, R.). New York: Grove Press.Google Scholar
Dorner, G. (1976) Hormones and Brain Differentiation. Amsterdam: Elsevier.Google Scholar
Eicher, W. (1981) HY Antigen in Transsexuality. Paper given to the fifth World Congress of Sexology, Jerusalem.Google Scholar
Eichwald, E. J. & Silmser, C. R. (1955) Untitled communication. Transplant Bulletin, 2, 148–9.Google Scholar
Eysenck, H. J. (1971) Personality and sexual adjustment. British Journal of Psychiatry, 118, 593–608.Google Scholar
Feder, H. H. (1981a) Hormonal actions on the sexual differentiation of the genitalia and the gonadotrophin-regulation system. In Neuro-endocrinology of Reproduction. (ed. Adler, N. T.). New York: Plenum.Google Scholar
Feder, H. H. (1981b) Perinatal hormones and their role in the development of sexually dimorphic behaviors. In Neuro-endocrinology of Reproduction. (ed. Adler, N. T.). New York: Plenum.Google Scholar
Federman, D. D. (1981) The requirements for sexual reproduction. Human Genetics, 58, 3–5.Google Scholar
Gerstoft, J., Maichow-Mollen, A., Bygbjerg, I., Dickmeiss, E., Enk, C., Halberg, P., Haar, S., Jacobsen, M., Jensen, K., Mejer, J., Nielson, J. O., Thomsen, H. K., Sondergaard, J. & Lorezen, I. (1982) Severe acquired immunodeficiency in European homosexual men. British Medical Journal, 285, 17–19.Google Scholar
Gessa, G. L. & Tegliamonte, A. (1974) Possible rôle of brain serotonin and dopamine in controlling male sexual behavior. In Serotonin—New Vistas (eds. Costa, E., Gessa, G. L. and Sandler, M.). New York: Raven Press.Google Scholar
Goodman, R. E. (1980) Photoquiz: The Marquis de Sade. British Journal of Sexual Medicine, 59, 57–8, 60, 75–6.Google Scholar
Goodman, R. E., Anderson, D. C., Bu'lock, D. E., Sheffield, B., Lynch, S. S. & Butt, W. R. (1982) Study of the effect of estradiol on gonadotrophin levels in untreated male to female transsexuals. Archives of Sexual Behaviour (in press).Google Scholar
Gorer, G. (1953) The Life and Ideas of the Marquis de Sade. London: Peter Owen.Google Scholar
Gorski, R. A. (1978) Sexual differentiation of the brain. Hospital Practice, 13, 55–62.CrossRefGoogle ScholarPubMed
Goy, R. W. & Goldfoot, D. A. (1975) Neuroendocrinology: animal models and problems of human sexuality. Archives of Sexual Behavior, 4, 405–20.Google Scholar
Hake, N. (1968) Encyclopaedia of Sexual Knowledge, 672–708. London: Encyclopaedic Press Ltd.Google Scholar
Haseltine, R. P. & Ohno, S. (1981) Mechanism of gonadal differentiation. Science, 21, 1272–84.Google Scholar
Imperato McGinley, J., Peterson, R. E., Gautier, T. & Sturla, E. (1979) Androgens and the evolution of male gender identity among male pseudo-hermaphrodites with 5 alpha-reductase deficiency. New England Journal of Medicine, 300, 1233–7.CrossRefGoogle Scholar
Jost, A. (1953) Studies on sex differentiation in mammals. Recent Progress in Hormone Research, 29, 1–35.Google Scholar
Kaplan, H. S. (1974) The New Sex Therapy: Active Treatment of Sexual Dysfunction. London: Bailliere Tindall.Google Scholar
Knobil, E. (1974) On the control of gonadotrophin secretion in the rhesus monkey. Recent Progress in Hormone Research, 30, 1–43.Google Scholar
Masters, W. H. & Johnson, V. E. (1979) Incidents and comparison of fantasy patterns. In Homosexuality in Perspective. Boston: Little, Brown & Co.Google Scholar
MacLusky, N. J. & Naftolin, F. (1981) Sexual differentiation of the central nervous system. Science, 211, 1294–303.Google Scholar
McEwan, B. S. (1981) Neurol gonadal steroid actions. Science, 211, 1303–11.Google Scholar
McIntosh, T. K., Vallano, M. L. & Barfield, R. J. (1980) Effects of morphine, β-endorphin and naloxone on catecholamine levels and sexual behavior in the male rat. Pharmacology, Biochemistry and Behavior, 13, 435–41.CrossRefGoogle ScholarPubMed
Mizejewski, G. J., Vonnegut, M. & Simon, R. (1980) Neonatal androgenisation using antibodies to alpha-feto protein. Brain Research, 188, 273–7.Google Scholar
Murphy, M. R. (1981) Endogenous opiates and the mechanism of male sexual behavior. (in press).Google Scholar
Ohno, S., Christian, L. C., Wachtel, S. S. & Koo, G. C. (1976) Hormone-like role of HY-antigen in bovine freemartin gonad. Nature, 261, 597–9.Google Scholar
Ohno, S., Nagai, Y., Ciccarese, S. & Iwata, H. (1979) Testisorganising HY-antigen and the primary sex-determining of mammals. Recent Progress in Hormone Research, 35, 449–75.Google Scholar
Pillard, R. C., Poumadere, J. & Carreta, R. A. (1981) Is homosexuality familial? A review, some data, and a suggestion. Archives of Sexual Behavior, 10, 465–75.CrossRefGoogle ScholarPubMed
Polani, P. E. (1981) Abnormal sex development in man: (1) anomalies in sex-determining mechanisms and (2) anomalies of sex-differentiating mechanisms. In Mechanisms of Sex Differentiation in Animals and Man. (eds. Austin, C. R. and Edwards, R. G.). London: Academic Press.Google Scholar
Wachtel, S. S. (1979) Immunogenetic aspects of abnormal sexual differentiation. Cell, 16, 691–5.Google Scholar
Wachtel, S. S. & Koo, G. C. (1981) HY-antigen in gonadal differentiation. In Mechanisms of Sex Differentiation in Animals and Man. (eds Austin, C. R. and Edwards, R. J.) London: Academic Press.Google Scholar
Ward, I. L. & Weisz, J. (1980) Maternal stress alters plasma testosterone in foetal males. Science, 207, 328–9.Google Scholar
Wilson, J. D., George, F. W. & Griffin, J. E. (1981) The hormonal control of sexual development. Science, 211, 1278–84.Google Scholar
Winter, J. S. D., Fairman, C. & Reyes, F. Sexual endocrinology of foetal and perinatal life. In Mechanisms of Sex Differentiation in Animals and Man. (eds. Austin, C. R. and Edwards, R. G.). London: Academic Press.Google Scholar
Wolf, , Fraccaro, M., Mayerova, A., Hech, T., Zuffardi, O. & Hamiester, H. (1980) Turner's syndrome patients are HY-positive. Human Genetics, 54, 315–8.Google Scholar
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