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The Assessment of Changes in Anxiety in a Drug Trial: A Comparison of Methods

Published online by Cambridge University Press:  29 January 2018

R. Kellner ,
A. V. Kelly  and
B. F. Sheffield
R. Kellner
Affiliation:
Department of Psychiatry, University of Liverpool
A. V. Kelly
Affiliation:
East Liverpool Psychiatric Day Hospital, and Rainhill Hospital
B. F. Sheffield
Affiliation:
Sefton General Hospital, Liverpool
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Extract

The purpose of this drug trial was to compare various methods of assessing changes in anxiety and to determine which would discriminate most effectively between the effects of treatment.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 114 , Issue 512 , July 1968 , pp. 863 - 869
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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References

Battle, C. C., Imber, S. D., Hoehn-Saric, R., Stone, A. R., Nash, E. H., and Frank, J. D. (1965). “Target complaints as criteria of improvement” Amer, J. Psychother., 20, 184–192.CrossRefGoogle Scholar
Behling, R. (1959). “Use of hydroxyzine pamoate in the treatment of pruritus” Clin. Med., 1363–1366.Google Scholar
Byrne, D. (1964). “Assessing personality variables and their alteration.” In: Personality Change (eds. Worchel, P. and Byrne, D.). New York, London: John Wiley and Sons.Google Scholar
Capstick, N. S., Corbett, M. F., Pare, C. M. B., Pryce, I. G., and Rees, L. W. (1965). “A comparative trial of diazepam (Valium) and amylobarbitone” Brit. J. Psychiat., 111, 517–519.CrossRefGoogle Scholar
Chieffi, M. (1965). “A two-part, double-blind study of the anti-neurotic action of tybamate” Dis. nerv. Syst., 26, 369–374.Google Scholar
Davison, K. (1963). “Evaluation of a new tranquillizer, Benzquinamide (P. 2647), by a sequential method” Brit. J. Psychiat., 109, 539–543.CrossRefGoogle Scholar
Eysenck, H. J. (1959). Manual of the Maudsley Personality Inventory, London.CrossRefGoogle Scholar
Frank, J. D., Nash, E. H., Stone, A. R., and Imber, S. D. (1963). “Immediate and long-term symptomatic course of psychiatric out-patients” Amer. J. Psychiat., 120, 429–439.CrossRefGoogle Scholar
Gliedman, L. H., Nash, E. H., Imber, S. D., Stone, A. R., and Frank, J. D. (1958). “Reduction of symptoms by pharmacologically inert substances and by short-term psychotherapy” A.M.A. Arch. Neurol. Psychiat., 79, 345–351.CrossRefGoogle Scholar
Greenhouse, H. R. (1963). “Of the use of hydroxyzine pamoate in the treatment of alcoholism” Med. Tms. (N.Y.),91, 1069–1073.Google Scholar
Hamilton, M. (1959). “The assessment of anxiety states by rating” Brit. J. med. Psychol., 32, 50–55.CrossRefGoogle Scholar
Hamilton, M. (1961). Lectures on the Methodology of Clinical Research. London: Livingstone, pp. 125–126.Google Scholar
Hinton, J. M. (1959). “A comparison of perphenazine (Fentazin), sodium amylobarbitone and a placebo in anxious and depressed out-patients” J. ment. Sci., 105, 872–877.CrossRefGoogle Scholar
Hoehn-Saric, R., Frank, J. D., Imber, S. D., Nash, E. H., Stone, A. R., and Battle, G. G. (1965). “Systematic preparation of patients for psychotherapy. 1. Effects on therapy behaviour and outcome” J. psychiat. Res., 2, 267–281.CrossRefGoogle Scholar
Jacobsen, M. (1965). “The use of rating scales in clinical research” Brit. J. Psychiat., 111, 545–546.CrossRefGoogle Scholar
Jenner, F. A., Kerry, R. J., and Parkin, D. (1961a). “A controlled trial of methamino-diazepoxide (chlordiazepoxide, ‘Librium’) in the treatment of anxiety in neurotic patients” J. ment. Sci., 107, 575–582.CrossRefGoogle Scholar
Jenner, F. A., Kerry, R. J., and Parkin, D. (1961b). “A controlled comparison of methaminodiazepoxide (chlordiazepoxide, ‘Librium’) and amylobarbitone in the treatment of anxiety in neurotic patients” J. ment. Sci., 107, 583–589.CrossRefGoogle Scholar
Kellner, R., and Sheffield, B. F. (1967). “Symptom Rating Test scores in neurotics and normals” Ibid., 113, 525–526.Google Scholar
Kerry, R. J., and Jenner, F. A. (1962). “A double blind cross-over comparison of diazepam (Valium) with chlordiazepoxide (Librium) in the treatment of neurotic anxiety” Psychopharmacologia, 3, 302–310.CrossRefGoogle Scholar
King, J. C. (1959). “The use of hydroxyzine in internal medicine” Int. Rec. Med., 669–671.Google Scholar
Lader, M. H., and Wing, L. G. (1966). Physiological Measures, Sedative Drugs and Morbid Anxiety. London: Oxford University Press, p. 89.Google Scholar
Lebo, D., Toal, R. A., and Brick, H. (1958). “Manifest anxiety in prisoners before and after CO2.” J. consult. Psychol., 22, 51–55.CrossRefGoogle Scholar
Le Gassicke, J., and McPherson, F. M. (1965). “A sequential trial of Wy 3498 (Oxazepam.)” Brit. J. Psychiat., 111, 521–525.CrossRefGoogle Scholar
Lipman, R. S., Cole, J. O., Park, L. D., and Rickels, K. (1965a). “Sensitivity of symptom and non-symptom focused criteria of out-patient drug efficacy” Am. J. Psychiat., 122, 24–27.CrossRefGoogle Scholar
Lipman, R. S., Rickels, K., Uhlenhuth, E. H., Park, L. C., and Fisher, S. (1965b). “Neurotics who fail to take their drugs” Brit. J. Psychiat., 111, 1043–1049.CrossRefGoogle Scholar
Lorr, M., McNair, D. M., Michaux, W. W., and Raskin, A. (1962). “Frequency of treatment and change in psychotherapy” J. abnorm. soc. Psychol., 64, 281–292.CrossRefGoogle Scholar
Park, L. C., Uhlenhuth, E. H., Lipman, R. S., Rickels, K., and Fisher, S. (1965). “A comparison of doctor and patient improvement rating in a drug (meprobamate) trial” Brit. J. Psychiat., 111, 535–540.CrossRefGoogle Scholar
Raab, E., Rickels, K., and Moore, E. (1964). “A double blind evaluation of tybamate in anxious neurotic medical clinic patients” Amer. J. Psychiat., 120, 1005–1007.CrossRefGoogle Scholar
Raymond, M. J., Lucas, C. J., Beesley, M. L., O'Connell, B. A., and Fraser Roberts, J. A. (1957). “A trial of five tranquillizing drugs in psychoneurosis” Brit. med. J., ii, 63–66.CrossRefGoogle Scholar
Rickels, K., Clark, T. W., Ewing, J. H., Klingensmith, W. C., Morris, H. M., and Smock, G. D. (1959). “Evaluation of tranquillizing drugs in medical out-patients” J. Amer. med. Ass., 171, 1649–1656.CrossRefGoogle Scholar
Robin, A. A. (1959). “Pecazine (‘Pacatal’) compared with amylobarbitone sodium in anxiety states” J. ment. Sci., 105, 1064–1069.CrossRefGoogle Scholar
Robinson, J. T., Davies, L. S., Knowles, J., and Kreitman, N. (1965). “A controlled trial of pericyazine in the treatment of anxiety states.” In: Proceedings of the Leeds Symposium on Behavioural Disorders. (ed. Jenner, F. A.). pp. 221–227. Dagenham, Essex: May & Baker Ltd.Google Scholar
Siegel, S. (1956). Nonparametric Statistics for the Behavioural Sciences. New York: McGraw Hill, p. 36.Google Scholar
Snedecor, G. U. (1956). Statistical Methods. Ames, Iowa: Iowa State College Press, p. 291.Google Scholar
Spelman, M., and Ley, P. (1968). “A comparison of Maudsley Personality Inventory scores, Manifest Anxiety and Hildreth Feeling Scale.” (Awaiting publication.)Google Scholar
Taylor, J. A. (1953). “A personality scale of manifest anxiety” J. abnorm. soc. Psychol., 48, 285–290.CrossRefGoogle Scholar
Winer, B. J. (1962). Statistical Principles in Experimental Design. New York: McGraw-Hill, p. 85.CrossRefGoogle Scholar
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