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Abnormal Growth Hormone Response to TRH in Chronic Adolescent Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

Ronit Weizman ,
Abraham Weizman ,
Sam Tyano ,
Irit Gil-Ad  and
Zvi Laron
Ronit Weizman
Affiliation:
Geha Psychiatric Hospital, W. B. Schwartz Institute for Psychiatric Research, Beilinson Medical Center, Sackler School of Medicine, Tel-Aviv University, 49 100 Petah-Tiqva, Israel
Abraham Weizman
Affiliation:
Geha Psychiatric Hospital
Sam Tyano
Affiliation:
Geha Psychiatric Hospital
Irit Gil-Ad
Affiliation:
Institute of Paediatric and Adolescent Endocrinology, Beilinson Medical Center
Zvi Laron
Affiliation:
Institute of Pediatric and Adolescent Endocrinology, Beilinson Medical Center
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Summary

There was a significant rise in the human growth hormone response to intravenous thyrotropin releasing hormone in 5 of 10 chronic schizophrenic adolescents maintained on antipsychotic agents, but in none of 10 age and sex matched control subjects. In 4 of the 5 patients with growth hormone rise there was a positive family history of schizophrenia, but such a family history was obtained in only one of the non-responding schizophrenics.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 141 , Issue 6 , December 1982 , pp. 582 - 585
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd Edition). Washington, DC: APA.Google Scholar
Braddock, L. E. & Blake, I. M. (1981) Neuroendocrine tests during treatment with neuroleptic drugs: II. The TRH test. British Journal of Psychiatry, 139, 404–7.Google Scholar
Gild-Ad, I., Dickerman, Z., Weizman, R., Weizman, A., Tyano, S. & Laron, Z. (1981) Abnormal growth hormone response to LRH and TRH in adolesce it schizophrenic patients. American Journal of Psychiatry, 138, 357–61.Google Scholar
Gonzales-Bracena, P., Kastin, A. Y., Schalch, D. S., Torres-Zamora, M., Perez-Basten, E., Kato, A. & Schally, A. V. (1973) Response to thyrotropin releasing hormone in patients with renal failure, and after infusion in normal men. Journal of Clinical Endocrinology and Metabolism, 36, 117–20.Google Scholar
Hedge, G. A. (1977) Role of prostaglandins in the regulation of anterior pituitary secretion. Life Science, 20, 17–34.Google Scholar
Horrobin, D. F. (1979) Schizophrenia: reconciliation of the dopamine, prostaglandin and opioid concepts and the role of the pineal. Lancet, 1, 529–31.Google Scholar
Irie, M. & Tsushima, T. (1972) Increase of serum growth hormone concentration following thyrotropin releasing hormone injection in patients with acromegy or gigantism. Journal of Clinical Endocrinology and Metabolism, 35, 97–107.Google Scholar
Linkowski, P., Brauman, H. & Mendlewicz, J. (1980) Growth hormone after TRH in women with depressive illness. British Journal of Psychiatry, 137, 229–32.Google Scholar
Malda, K., Kato, Y., Ohgo, S., Chichara, K., Yoshimoto, Y., Yamaguchi, N., Kuromaru, S. & Imura, H. (1975) Growth hormone and prolactin release after injection of thyrotropin-releasing hormone in patients with depression. Journal of Clinical Endocrinology and Metabolism, 40, 501–5.Google Scholar
Malda, K., Kato, Y., Yamaguchi, N., Chichara, K., Ohgo, S., Iwasaki, Y., Yoshimoto, Y., Moridera, K., Kuromaru, S. & Imura, H. (1976) Growth hormone release following thyrotropin releasing hormone injection in patients with anorexia nervosa. Acta Endocrinologica, 8, 1–8.Google Scholar
Panerai, A. E., Salerro, F. & Maneschi, M. (1977) Growth hormone and prolactin response to thyrotropin releasing hormone in patients with severe liver disease. Journal of Clinical Endocrinology and Metabolism, 45, 134–40.Google Scholar
Takahara, Y., Arimura, A. & Schally, A. V. (1974) Stimulation of prolactin and growth hormone release by TRH infused with the hypophyseal portal vessel. Proceedings of Society for Experimental Biology and Medicine, 146, 831–5.Google Scholar
Udeschini, G., Cocchi, D., Panerai, A. E., Gil-Ad, I., Rossi, G. L., Chiodini, P. G., Liuzzi, A. & Muller, E. E. (1976) Stimulation of growth hormone by thyrotropin releasing hormone in the hypophysectomized rat bearing an ectopic pituitary. Endocrinology, 98, 807–14.Google Scholar
Weiner, R. I. & Ganong, W. F. (1978) Role of brain monoamines and histamine in the regulation of anterior pituitary secretion. Physiological Reviews, 58, 905–76.Google Scholar
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