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3H-Imipramine Binding to Previously Frozen Platelet Membranes from Depressed Patients, Before and After Treatment

Published online by Cambridge University Press:  02 January 2018

David Healy ,
Andreas E. Theodorou ,
Andrew M. Whitehouse ,
Kevin M. Lawrence ,
William White ,
Helen Wilton-Cox ,
Sally M. Kerry ,
Roger W. Horton  and
Eugene S. Paykel
David Healy
Affiliation:
Department of Psychiatry, University of Cambridge
Andreas E. Theodorou
Affiliation:
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London
Andrew M. Whitehouse
Affiliation:
Department of Psychiatry, University of Cambridge
Kevin M. Lawrence
Affiliation:
Research Technician, Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London
William White
Affiliation:
Department of Psychiatry, University of Cambridge
Helen Wilton-Cox
Affiliation:
Department of Psychiatry, University of Cambridge
Sally M. Kerry
Affiliation:
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London
Roger W. Horton*
Affiliation:
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London SW17 0RE
Eugene S. Paykel
Affiliation:
Department of Psychiatry, University of Cambridge
*
∗Correspondence
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Extract

3H-imipramine binding in 39 drug-free patients with major depression and 44 healthy controls did not differ significantly between the two groups, in male or female subjects or in subgroups of depressed patients divided by endogenicity or dexamethasone suppression test result. 3H-imipramine binding in depressed patients drug-free for less than three weeks did not differ from those drug-free for longer intervals or from controls. A significant seasonal variation of 3H-imipramine Bmax was found, with lower values in summer and autumn. Treatment of depressed patients with imipramine or lofepramine for six weeks increased KD and Bmax. Methodological modification (in preparation and storage of platelets) does not explain the major differences in results between this study (using frozen platelets), a previous one (using freshly prepared platelets) and others in general, although it might contribute to the range of values reported.

Type
Papers
Information
The British Journal of Psychiatry , Volume 157 , Issue 2 , August 1990 , pp. 208 - 215
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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