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The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms

Published online by Cambridge University Press:  24 April 2002

ALEKSANDR V. MAKEYEV  and
STEPHEN A. LIEBHABER
ALEKSANDR V. MAKEYEV
Affiliation:
Departments of Genetics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
STEPHEN A. LIEBHABER
Affiliation:
Departments of Genetics and Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
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Abstract

The poly(C) binding proteins (PCBPs) are encoded at five dispersed loci in the mouse and human genomes. These proteins, which can be divided into two groups, hnRNPs K/J and the αCPs (αCP1-4), are linked by a common evolutionary history, a shared triple KH domain configuration, and by their poly(C) binding specificity. Given these conserved characteristics it is remarkable to find a substantial diversity in PCBP functions. The roles of these proteins in mRNA stabilization, translational activation, and translational silencing suggest a complex and diverse set of post-transcriptional control pathways. Their additional putative functions in transcriptional control and as structural components of important DNA-protein complexes further support their remarkable structural and functional versatility. Clearly the identification of additional binding targets and delineation of corresponding control mechanisms and effector pathways will establish highly informative models for further exploration.

Keywords

αCPhnRNP KmRNA stabilitymRNA translationpoly(C) binding proteinspost-transcriptional controls
Type
REVIEW
Information
RNA , Volume 8 , Issue 3 , March 2002 , pp. 265 - 278
Copyright
© 2002 RNA Society

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