Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-24T11:18:54.378Z Has data issue: false hasContentIssue false
  • English
  • Français

Peptidyl transferase activity catalyzed by protein-free 23S ribosomal RNA remains elusive

Published online by Cambridge University Press:  01 May 1999

PHILIPP KHAITOVICH ,
TANEL TENSON ,
ALEXANDER S. MANKIN  and
RACHEL GREEN
PHILIPP KHAITOVICH
Affiliation:
Center for Pharmaceutical Biotechnology—m/c 870, University of Illinois, Chicago, Illinois 60607, USA
TANEL TENSON
Affiliation:
Estonian Biocenter, Riia 23, Tartu, EE2400, Estonia
ALEXANDER S. MANKIN
Affiliation:
Center for Pharmaceutical Biotechnology—m/c 870, University of Illinois, Chicago, Illinois 60607, USA
RACHEL GREEN
Affiliation:
Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In two recent articles by Nitta et al. (1998a, 1998b), evidence was presented that in vitro-transcribed protein-free 23S rRNA of Escherichia coli (and its individual domains) can catalyze peptide bond formation. The implications of these studies are considerable because demonstration of catalytic activity associated with protein-free 23S rRNA would be fundamental to our understanding of the mechanism and evolution of protein synthesis (Noller et al., 1992; Khaitovich et al., 1999).

Keywords

peptide bond formationribosomeRNA catalysisrRNA
Type
LETTERS TO THE EDITOR
Information
RNA , Volume 5 , Issue 5 , May 1999 , pp. 605 - 608
Copyright
© 1999 RNA Society