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Peptidyl transferase activity catalyzed by protein-free 23S ribosomal RNA remains elusive

Published online by Cambridge University Press:  01 May 1999

PHILIPP KHAITOVICH ,
TANEL TENSON ,
ALEXANDER S. MANKIN  and
RACHEL GREEN
PHILIPP KHAITOVICH
Affiliation:
Center for Pharmaceutical Biotechnology—m/c 870, University of Illinois, Chicago, Illinois 60607, USA
TANEL TENSON
Affiliation:
Estonian Biocenter, Riia 23, Tartu, EE2400, Estonia
ALEXANDER S. MANKIN
Affiliation:
Center for Pharmaceutical Biotechnology—m/c 870, University of Illinois, Chicago, Illinois 60607, USA
RACHEL GREEN
Affiliation:
Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA

Abstract

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In two recent articles by Nitta et al. (1998a, 1998b), evidence was presented that in vitro-transcribed protein-free 23S rRNA of Escherichia coli (and its individual domains) can catalyze peptide bond formation. The implications of these studies are considerable because demonstration of catalytic activity associated with protein-free 23S rRNA would be fundamental to our understanding of the mechanism and evolution of protein synthesis (Noller et al., 1992; Khaitovich et al., 1999).

Keywords

peptide bond formationribosomeRNA catalysisrRNA
Type
LETTERS TO THE EDITOR
Information
RNA , Volume 5 , Issue 5 , May 1999 , pp. 605 - 608
Copyright
© 1999 RNA Society