Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-24T08:44:15.693Z Has data issue: false hasContentIssue false

Prevention of falls in old people – a review

Published online by Cambridge University Press:  19 July 2013

Magnus K. Karlsson*
Affiliation:
Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden
Caroline Karlsson
Affiliation:
Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden
Maria Cöster
Affiliation:
Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden
Håkan Magnusson
Affiliation:
Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden
Björn E. Rosengen
Affiliation:
Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden
*
Address for correspondence: Magnus Karlsson, Department of Orthopaedics, Skåne University Hospital, SE-205 02 Malmö, Sweden. Email: [email protected]
Rights & Permissions [Opens in a new window]

Summary

Physical training, if including specific different training modalities, reduces the fall risk in healthy community-dwelling older people, as does a home hazards modification programme. Vitamin D supplementation in older individuals with low levels of vitamin D, adjustment of psychotropic medication, and structured modification of multi-pharmacy are all drug-focused programmes that reduce the number of falls. Anti-slip shoe devices during icy conditions for older people who walk outdoors and multifaceted podiatry in patients with specific foot disability reduce the fall risk. First eye cataract surgery and pacemakers in patients with cardio-inhibitory carotid sinus hypersensitivity are surgical interventions that reduce the fall risk. Multi-factorial preventive programmes that include training, both individually designed and generally prescribed, also reduce the fall frequency. With this in mind, we ought to initiate fall preventive programmes in older people, especially in high- risk groups, to reduce the number of falls and fallers in society.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2013 

Introduction

The number of fragility fractures has risen during the last 50 yearsReference Rosengren, Ahlborg, Mellstrom, Nilsson, Bjork and Karlsson1 so that the worldwide prevalence in adults above the age of 50 years is 9.0 million, of which 1.6 million are of the hip, 1.7 million the forearm and 1.4 million clinically diagnosed vertebral fractures.Reference Johnell and Kanis2 The increase is estimated to continue, so that by the year 2050 there will be 6.3 million hip fractures globally, half of these in AsiaReference Cooper, Campion and Melton3 (Fig. 1). This will impose a significant health care burden worldwide.Reference Rosengren, Ahlborg, Mellstrom, Nilsson, Bjork and Karlsson1 Therefore we must introduce measures that reduce the number of falls and fractures.

Figure 1. Estimated number of hip fractures in four geographic regions in 1990 and 2050Reference Cooper, Campion and Melton3

Falls are commonly found in older people. One-third of community dwellers aged over 65 years and 60% of individuals in nursing and retirement homes fall each year.Reference Tinetti, Speechley and Ginter4 Furthermore, women fall more often than men.Reference Tinetti, Speechley and Ginter4 Falls are also often followed by pain syndromes, functional limitations, dislocations, serious soft tissue injuries, fractures, high healthcare costs and high mortality.Reference Kannus, Sievanen, Palvanen, Jarvinen and Parkkari5 About 15% of falls in patients living in the communityReference Tinetti, Speechley and Ginter4 and 20% in institutionalized patientsReference Tinetti, Liu and Ginter6 result in a significant injury, and 12% of all falls in older people are followed by a fracture.Reference Tinetti, Doucette, Claus and Marottoli7 In addition, 23% of trauma-related deaths in patients above age 65 years and 34% in those above age 85 years follow a fall.Reference Fingerhut and Warner8

Fractures may provide the largest healthcare burden among fall-related injuries.Reference Rice and MacKenzie9 Fragility fractures, i.e. fractures of the proximal humerus, distal forearm, vertebrae, pelvis, hip and the tibial condyles in older individuals due to low-energy trauma share common features, such as having a higher incidence in women than in men and an exponential increase with age.Reference Melton and Riggs10 The incidence of hip fractures has increased during the last 50 yearsReference Rosengren, Ahlborg, Mellstrom, Nilsson, Bjork and Karlsson1, Reference Kannus, Niemi, Parkkari, Palvanen, Vuori and Jarvinen11 even if in many western countries there has been a decline in the incidence since the end of the twentieth century.Reference Rosengren, Ahlborg, Mellstrom, Nilsson, Bjork and Karlsson1, Reference Kannus, Niemi, Parkkari, Palvanen, Vuori and Jarvinen11 Despite this, the total number of hip fractures is still increasing due to changes in population demographics. As the proportion of older people in the population is due to grow even larger, the total number of fragility fractures will continue to rise,Reference Cooper, Campion and Melton3 a fact that increases the need of fall- and fracture-reducing interventions. As a fall is one of the most striking risk factors for fractures, and as there exists strong evidence supporting the effectiveness of several fall preventive strategies, this review summarizes the fall prevention programmes that have been shown to have beneficial effects in randomized controlled trials (RCTs).

Search methods

We identified potentially interesting studies through a structured search in PubMed from all years by using the terms: ‘accidental falls’, ‘physical therapy’, ‘equipment’, ‘supplies’, ‘self-help devices’, ‘protective devices’, ‘environmental intervention’, ‘home modification’, ‘exercise’, ‘exercise therapy’, ‘physical education’ and ‘training’. From the identified studies, we included only those studies which, using RCTs, evaluated the effects of interventions designed to reduce falls in older people (individuals aged 60 years or more or described as elderly, seniors or older). The participants had to be living in the community at home or in places of residence that did not provide residential health-related care. Trials that included younger participants, for example those recruited on the basis of a medical condition such as a stroke or Parkinson's disease were only included if the mean age minus one standard deviation was more than 60 years. Some references found evaluated interventions in nursing care facilities or hospitals, but these data are presented separately. In studies with participants living in different settings, participants were included only if data were provided for subgroups based on setting. Intervention programmes were compared with ‘usual care’ or ‘placebo’. Studies that evaluated two types of fall-prevention interventions were also included. Finally, we went through the included studies and excluded those without end-point variable rate or number of falls or number of participants sustaining at least one fall during follow-up (fallers). Apart from these studies, we also included recently published structured reviews and Cochrane reviews within the field that summarized the outcome in published RCTs.Reference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12Reference Liu and Latham20 We chose to present central studies reported in these Cochrane reviews in the figures; that is, not all of the total of 159 RCTs reported in the latest Cochrane review are included in the figures, while additional reports could be referred to in the text. Finally, we also reviewed the reference lists of each to identify papers fulfilling the above-mentioned criteria to add further relevant RCTs.

The meta-analyses calculations referred to in this paper are published in detail in cited Cochrane reviews.Reference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14 In summary, in the meta-analyses, data from different RCTs with comparable interventions and participant characteristics were pooled by use of a generic inverse variance method. Calculated pooled rate ratios for total number of falls or risk ratios for being a faller with 95% confidence intervals were estimated through the fixed-effect model. Where there was substantial statistical heterogeneity, data were pooled using a random effect model.Reference Close, Ellis, Hooper, Glucksman, Jackson and Swift21

Exercise

Physical training in community-living old individuals reduces the risk of fallingReference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12, Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13, Reference Sherrington, Whitney, Lord, Herbert, Cumming and Close19, Reference Campbell, Robertson, Gardner, Norton and Buchner22Reference Liu-Ambrose, Khan, Eng, Lord and McKay49 (Fig. 2) and is generally accepted as the most effective fall-prevention strategy in the community-living population.Reference Davis, Robertson, Ashe, Liu-Ambrose, Khan and Marra50, Reference Frick, Kung, Parrish and Narrett51 Exercise has also been reported as the most cost-effective fall-preventive strategy.Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13, Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14 Among the different training strategies, multi-component exercise programmes that include balance training and muscle-strength training have been the most effective interventions, followed by flexibility and endurance training.Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13, Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14 The training should be performed often and with high frequency.Reference Province, Hadley, Hornbrook, Lipsitz, Miller, Mulrow, Ory, Sattin, Tinetti and Wolf25, Reference Li, Harmer, Fisher, McAuley, Chaumeton, Eckstrom and Wilson44 Group training, where at least two different training components are included, has, in community-living old people above age 60 years decreased the fall rate by 22% (relative risk (RR) 0.78, 95% confidence interval (CI) 0.71–0.86) and the risk of falling by 17% (RR 0.83, 95% CI 0.72–0.97) (Fig. 2). Training classes that included gait balance alternating with functional training significantly reduced rate of falls by 27% (RR 0.73, 95% CI 0.54–0.98) (Fig. 2). RCTs comparing different types of exercise or methods of delivery have not found any differences.Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13

Figure 2. Comparison of number of falls in community-living older people exposed to intervention with different types of exercise versus controls reported in several randomized controlled trials (RCTs)

Individually designed exercise programmes with more than one exercise modality, conducted at home, is another approach that reduces the number of falls in community-living old individuals by 34% (RR 0.66, 95% CI 0.53–0.82) and the risk of falling by 23% (RR 0.77, 95% CI 0.61–0.97)Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13 (Fig. 2). However, training can be beneficial even if using only one exercise modality. Such an example is Tai Chi training where the beneficial effects include both strength and balance training. In the general old population this type of training reduced the number of fallers by close to 50% in one RCT published by the FICSIT group (Frailty and Injuries: Co-operative Studies of Intervention Techniques)Reference Wolf, Barnhart, Ellison and Coogler52 and a meta-analysis that included unselected community-living older people supported this notion when reporting that Tai Chi reduced the number of falls by 37% (RR 0.63, 95% CI 0.52–0.78) and the number of fallers by 35% (RR 0.65, 95% CI 0.51–0.82) (Fig. 2). The beneficial effect is usually referred to the fact that Tai Chi includes both strength and balance training.Reference Voukelatos, Cumming, Lord and Rissel53 Another recent published RCT showed that home-based balance and strength training in older community-living individuals aged 70 years or older, who had two or more falls or one injurious fall in the past 12 months, was followed by a 31% reduction in the number of falls (RR 0.69, 95% CI 0.48–0.99).Reference Clemson, Fiatarone Singh, Bundy, Cumming, Manollaras, O'Loughlin and Black54 A music-based multi-task exercise programme in community-dwelling individuals older than 65 years who were at increased risk of falling was also effective, and the programme resulted in 54% fewer falls in the exercise group (RR 0.46; 95% CI 0.27–0.79).Reference Trombetti, Hars, Herrmann, Kressig, Ferrari and Rizzoli55 The authors concluded that functional-based exercise should be a focus for interventions to protect older, high-risk individuals from falling and that the effect of physical training as a fall reductive strategy is less effective in institutionalized individuals.Reference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12, Reference Mulrow, Gerety, Kanten, Cornell, DeNino, Chiodo, Aguilar, O'Neil, Rosenberg and Solis56Reference Sihvonen, Sipila, Taskinen and Era62 (Fig. 3). Supervised training in institutionalized individuals above age 65 years reduced the risk of falling by 56% (RR 0.44, 95% CI 0.20–0.97)Reference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12 in one meta-analysis, but further subgroup analyses showed that the positive effect was only found in older people in sub-acute care hospitals, and not in those staying in general nursing care facilitiesReference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12 (Fig. 3). However, it should be noted that gait, balance and co-ordination exercises utilizing a mechanical apparatus in individuals in nursing homes did reduce the rate of falls by 55% (RR 0.45, 95% CI 0.24–0.85). Therefore, we cannot exclude that specific types of training in specific groups actually can reduce the fall frequency also in older individuals staying in nursing homes or other type of institutions (Fig. 3).

Figure 3. Comparison of number of falls in older people living in nursing home or hospitals exposed to intervention with different types of exercise versus controls reported in several RCTs

Vitamin D

Vitamin D supplements provided to unselected community-living older people did not reduce the number of falls (RR 0.95, 95% CI 0.80–1.14) (Fig. 4).Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13, Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14, Reference Latham, Anderson, Lee, Bennett, Moseley and Cameron63Reference Sato, Manabe, Kuno and Oizumi69 Slightly more positive conclusions could be drawn when the supplement was given to institutionalized old individuals, where the total number of falls was reduced by 28% (RR 0.72, 95% CI 0.55–0.95) (Fig. 4).Reference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12 In old people with low vitamin D levels, the sub-group analyses revealed that the number of falls was reduced by 43% (RR 0.57, 95% CI 0.37–0.89) (Fig. 4), as was the number of fallers by 35% (RR 0.65, 95% CI 0.46–0.91).Reference Pfeifer, Begerow, Minne, Abrams, Nachtigall and Hansen66, Reference Dhesi, Jackson, Bearne, Moniz, Hurley, Swift and Allain68 No fall reduction was seen in old people with normal vitamin D levels. However, the type of supplement also seems to be of importance, as calcitriol reduced the number of falls by 36% (RR 0.64, 95% CI 0.49–0.82)Reference Gallagher, Fowler, Detter and Sherman67 while alfacalcidol did not (RR 1.08, 95% CI 0.75–1.57)Reference Sato, Kaji and Oizomi70 (Fig. 4). Vitamin D supplements may reduce the number of falls but probably only in those with low vitamin D levels and maybe only with specific types of vitamin D drugs.

Figure 4. Comparison of number of falls in community-living older people exposed to vitamin D supplement with or without calcium versus controls reported in several RCTs

Medication

Multi-pharmacy and combinations of specific drugs may be associated with increased fall risk in the older population. A structured prescription modification programme could therefore hypothetically reduce the fall risk. One RCT demonstrated this in the intervention group, where a gradual withdrawal of psychotropic medication resulted in a 66% reduction in the number of falls (RR 0.34, 95% CI 0.16–0.73) (Fig. 5).Reference Campbell, Robertson, Gardner, Norton and Buchner22 Fall preventive education for family physicians that included academic teaching, feedback on prescribing practices and financial rewards combined with self-assessment of medication followed by a medication review with modification of prescriptions in community-dwelling older people was found to reduce the risk of falling by 39% (RR 0.61, 95% CI 0.41–0.91)Reference Pit, Byles, Henry, Holt, Hansen and Bowman71 (Fig. 5). Modification of prescriptions could also have an effect on individuals staying in institutions, since beneficial effects were found in one RCT that evaluated a prescribing modification programme by pharmacists in nursing care facilities or hospitals, an intervention that reduced the fall frequency by 38% (RR 0.62, 95% CI 0.53–0.72).Reference Campbell, Robertson, Gardner, Norton and Buchner22

Figure 5. Comparison of number of falls in community-living older people exposed to drug withdrawal, surgery and foot assessment versus controls reported in several RCTs

Surgery

Surgical interventions may be effective in reducing falls in specific risk groups. Cardiac pacemakers, in patients with cardioinhibitory carotid sinus hypersensitivity, were in one published RCT reported to reduce the rate of falls by 58% (RR 0.42, 95% CI 0.23–0.75) (Fig. 5).Reference Kenny, Richardson, Steen, Bexton, Shaw and Bond72 Cataract surgery for the first eye was, in another RCT, found to reduce the rate of falls by 34% (RR 0.66, 95% CI 0.45–0.95) (Fig. 5).Reference Harwood, Foss, Osborn, Gregson, Zaman and Masud73 Cataract surgery for the second eye was, however, not associated with a reduced fall rate (RR 0.68, 95% CI 0.39–1.17)Reference Foss, Harwood, Osborn, Gregson, Zaman and Masud74 (Fig. 5).

Home hazards

Modification of home hazards in the general older population reduce the number of falls (RR 0.81, 95% CI 0.68–0.97) (Fig. 6) and the number of fallers (RR 0.88, 95% CI 0.80–0.96).Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14, Reference Lin, Wolf, Hwang, Gong and Chen41, Reference Stevens, Holman and Bennett75Reference Day, Fildes, Gordon, Fitzharris, Flamer and Lord80 Modifications of home hazards in individuals above age 75 years with visual impairment that removed or changed loose floor mats, painted the edges of steps, reduced glare, installed grab bars and stair rails, removed clutter and improved lighting where needed, was followed by a 41% fall reduction (RR 0.59, 95% CI 0.42–0.83) (Fig. 6) and 24% reduction in number of fallers (RR 0.76, 95% CI 0.62–0.95).Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13, Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14, Reference Campbell, Robertson, La Grow, Kerse, Sanderson, Jacobs, Sharp and Hale78 A pooled sub-group analysis revealed that a home safety programme reduced the fall risk by 44% (RR 0.56, 95% CI 0.42–0.76) (Fig. 6) and the number of fallers by 22% (RR 0.78, 95% CI 0.64–0.95) in high-risk individuals, such as individuals with a history of a fall or multiple risk factors. Home hazard assessment and modification of risk factors should therefore be provided to all older people, but particularly focused on high-risk individuals as the interventions seem more effective in people at higher risk of falling.Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14

Figure 6. Comparison of number of falls in community-living older people exposed to intervention with home hazard assessment followed by risk factor reduction versus controls reported in several RCTs

Footwear

The type of footwear may influence the risk of falling.Reference Menant, Steele, Menz, Munro and Lord81 Anti-slip shoe devices have, in one study, been shown to reduce the rate of falls by 58% (RR 0.42, 95% CI 0.22–0.78) (Fig. 5), but only in old individuals who walked outdoors during icy conditionsReference McKiernan82 (Fig. 5). Anti-slip shoe devices should therefore be recommended to ambulatory old people who walk outdoors under icy conditions and multifaceted podiatry to patients with specific foot disability. Another RCT that evaluated the effect of multifaceted podiatry including foot and ankle exercise found that this intervention reduced the fall risk by 36% (RR 0.64, 95% CI 0.45–0.91) (Fig. 5) compared with standard podiatry in patients with disabling foot pain.Reference Spink, Menz, Fotoohabadi, Wee, Landorf, Hill and Lord83

Generalized multifaceted intervention

Hypothetically, it ought to be beneficial to modify as many risk factors as possible. One approach would be to prescribe generally designed intervention programmes that include a fixed combination of different components of interventions that are delivered to all participants independently of individual demands. Examples of such programmes are those including exercise, care planning, medical and/or diagnostic approaches, changes in physical environment, education programmes, calcium and vitamin D supplementation, medication review and removal of physical restraints.Reference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14, Reference Oliver, Connelly, Victor, Shaw, Whitehead, Genc, Vanoli, Martin and Gosney18, Reference Campbell, Robertson, La Grow, Kerse, Sanderson, Jacobs, Sharp and Hale78, Reference Hill, Mossman, Stockdale and Crome84Reference Swanenburg, de Bruin, Stauffacher, Mulder and Uebelhart87 (Fig. 7). Generalized programmes have, in RCTs, been found to reduce the fall rate by 31% when including exercise, education and a home safety intervention (RR 0.69, 95% CI 0.50–0.96),Reference Clemson, Cumming, Kendig, Swann, Heard and Taylor85 by 81% when including exercise plus nutritional supplementation in vitamin D and calcium replete women (RR 0.19, 95% CI 0.05–0.68),Reference Swanenburg, de Bruin, Stauffacher, Mulder and Uebelhart87 by 24% when including exercise and home safety assessment (RR 0.76, 95% CI 0.60–0.97),Reference Day, Fildes, Gordon, Fitzharris, Flamer and Lord80 by 27% when including exercise plus vision assessment (RR 0.73, 95% CI 0.59–0.91),Reference Day, Fildes, Gordon, Fitzharris, Flamer and Lord80 by 23% when including exercise plus vision and home safety assessment (RR 0.67, 95% CI 0.51–0.88)Reference Day, Fildes, Gordon, Fitzharris, Flamer and Lord80 and by 23% when including educational intervention combined with free access to an assessment at a geriatric clinic (RR 0.77, 95% CI 0.63–0.94)Reference Assantachai, Chatthanawaree, Thamlikitkul, Praditsuwan and Pisalsarakij88 (Fig. 7).

Figure 7. Comparison of number of falls in community-living older people exposed to generalized multifaceted interventions versus controls reported in several RCTs

Individualized multifactorial intervention

In individualized multifaceted intervention programmes, each individual would be evaluated for risk factors and then be assigned to an individually designed prevention programmeReference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13, Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14, Reference Close, Ellis, Hooper, Glucksman, Jackson and Swift21, Reference Davison, Bond, Dawson, Steen and Kenny89Reference Elley, Robertson, Garrett, Kerse, McKinlay, Lawton, Moriarty, Moyes and Campbell101 (Fig. 8). Similar programmes have been shown to reduce the rate of falls in community-dwelling old adults by 25% (RR 0.75, 95% CI 0.65–0.86) (Fig. 8).Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13, Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14 In hospital settings, these multifactorial interventions reduced the rate of falls by 31% (RR 0.69, 95% CI 0.49–0.96) (Fig. 8) and the risk of falling by 27% (RR 0.73, 95% CI 0.56–0.96). The number of falls was not reduced in individuals living in nursing home facilities (RR 0.82, 95% CI 0.68–1.08), even if further sub-analysis revealed that specific types of interventions with multidisciplinary team approaches together with physical training reduced the rate of falling also in nursing home residents by 40% (RR 0.60, 95% CI 0.5–0.72).Reference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12 It should also be noted that all multiple intervention trials that have been shown to reduce the fall risk include some type of physical training in the interventionReference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14 (Fig. 8) and that multi-factorial risk assessment in conjunction with comprehensive management of identified risk factors are usually recommended to focus on high-risk populations. In the recently updated American Geriatric Society (AGS) clinical practice guidelines, this especially accounts for older adults who have sustained two falls or more in the recent year, have gait or balance problems or have presented with an acute fall.

Figure 8. Comparison of number of falls in community-living older people exposed to individualized multifactorial interventions versus controls reported in several RCTs

Interventions with harmful effects

An intervention programme can also increase the fall rate. Two RCTs have reported that intervention with vision assessment, eye examination, new spectacles and/or ophthalmology treatment in conjunction with mobility training and canes increased the fall rate by 57% (RR 1.57, 95% CI 1.19–2.06)Reference Cumming, Ivers, Clemson, Cullen, Hayes, Tanzer and Mitchell77, Reference Day, Fildes, Gordon, Fitzharris, Flamer and Lord80 (Fig. 6). Exercise in hospitalized individuals that included several different training modalities was in one RCT found to increase the fall rate by 172% (RR 2.72, 95% CI 1.42–5.19)Reference Schoenfelder59 (Fig. 3) and when using pooled data from several RCTs that included different types of training modalities, by 37% in people in hospital settings (RR 1.37, 95% CI 1.01–1.85)Reference Cameron, Murray, Gillespie, Robertson, Hill, Cumming and Kerse12 (Fig. 3). This highlights the importance of drawing inferences for fall preventive effect only in cohorts similar to the one evaluated in RCTs and not directly transfer the conclusion of beneficial effects in one cohort to other populations.

Cost benefits

In one review there were eight RCTs that included economic evaluation as an outcome.Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13, Reference Gillespie, Robertson, Gillespie, Sherrington, Gates, Clemson and Lamb14 These studies infer that there is weak evidence that prevention strategies for fall reduction can be cost saving during the trial period, but also during the rest of the lifespan of the participants. All reports also infer that the prevention strategies with fall-reducing effects ought to be targeted at high-risk sub-groups of old people to achieve greatest cost-beneficial effects.Reference Gillespie, Robertson, Gillespie, Lamb, Gates, Cumming and Rowe13

Conclusions

Fall risk in community-living old individuals is reduced by:

  • Regular exercise that includes multicomponent training modalities

  • Reduction of home hazards

  • Vitamin D supplements in individuals with low levels of vitamin D

  • Adjustment of psychotropic medication

  • Structured modification of multi-pharmacy

  • Anti-slip shoe devices in older individuals walking outdoors during icy conditions

  • Multifaceted podiatry to patients with specific foot disability

  • First eye cataract surgery in patients with visual impairment

  • Pacemakers in patients with cardioinhibitory carotid sinus hypersensitivity

  • Generalized multifactorial fall prevention programmes

  • Individually designed multifactorial fall prevention programmes.

Conflict of interest

There are no competing interests for any of the authors.

References

1Rosengren, BE, Ahlborg, HG, Mellstrom, D, Nilsson, JA, Bjork, J, Karlsson, MK. Secular trends in Swedish hip fractures 1987–2002: birth cohort and period effects. Epidemiology 2012; 23: 623–30.CrossRefGoogle ScholarPubMed
2Johnell, O, Kanis, JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006; 17: 1726–33.CrossRefGoogle ScholarPubMed
3Cooper, C, Campion, G, Melton, LJ 3rd. Hip fractures in the elderly: a world-wide projection. Osteoporos Int 1992; 2: 285–89.CrossRefGoogle ScholarPubMed
4Tinetti, ME, Speechley, M, Ginter, SF. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988; 319: 1701–7.CrossRefGoogle ScholarPubMed
5Kannus, P, Sievanen, H, Palvanen, M, Jarvinen, T, Parkkari, J. Prevention of falls and consequent injuries in elderly people. Lancet 2005; 366: 1885–93.CrossRefGoogle ScholarPubMed
6Tinetti, ME, Liu, WL, Ginter, SF. Mechanical restraint use and fall-related injuries among residents of skilled nursing facilities. Ann Intern Med 1992; 116: 369–74.CrossRefGoogle ScholarPubMed
7Tinetti, ME, Doucette, J, Claus, E, Marottoli, R. Risk factors for serious injury during falls by older persons in the community. J Am Geriatr Soc 1995; 43: 1214–21.CrossRefGoogle ScholarPubMed
8Fingerhut, L, Warner, M. Injury Chartbook. Health, United States, 1996–1997. Hyattsville, Maryland., 1997.Google Scholar
9Rice, D, MacKenzie, E, Associates. Cost of injury in the United States: a report to congress. San Francisco: University of California, 1989.Google Scholar
10Melton, LJ 3rd, Riggs, BL. Risk factors for injury after a fall. Clin Geriatr Med 1985; 1: 525–39.CrossRefGoogle ScholarPubMed
11Kannus, P, Niemi, S, Parkkari, J, Palvanen, M, Vuori, I, Jarvinen, M. Nationwide decline in incidence of hip fracture. J Bone Miner Res 2006; 21: 1836–38.CrossRefGoogle ScholarPubMed
12Cameron, ID, Murray, GR, Gillespie, LD, Robertson, MC, Hill, KD, Cumming, RG, Kerse, N. Interventions for preventing falls in older people in nursing care facilities and hospitals. Cochrane Database Syst Rev 2010; 1: CD005465.Google Scholar
13Gillespie, LD, Robertson, MC, Gillespie, WJ, Lamb, SE, Gates, S, Cumming, RG, Rowe, BH. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2009; 2: CD007146.Google Scholar
14Gillespie, LD, Robertson, MC, Gillespie, WJ, Sherrington, C, Gates, S, Clemson, LM, Lamb, SE. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev 2012; 9: CD007146.Google Scholar
15McClure, R, Turner, C, Peel, N, Spinks, A, Eakin, E, Hughes, K. Population-based interventions for the prevention of fall-related injuries in older people. Cochrane Database Syst Rev 2005; 1: CD004441.Google Scholar
16Karinkanta, S, Piirtola, M, Sievanen, H, Uusi-Rasi, K, Kannus, P. Physical therapy approaches to reduce fall and fracture risk among older adults. Nat Rev Endocrinol 2010; 6: 396407.CrossRefGoogle ScholarPubMed
17Lyons, RA, John, A, Brophy, S, Jones, SJ, Johansen, A, Kemp, A, Lannon, S, Patterson, J, Rolfe, B, Sander, LV, Weightman, A. Modification of the home environment for the reduction of injuries. Cochrane Database Syst Rev 2006; 4: CD003600.Google Scholar
18Oliver, D, Connelly, JB, Victor, CR, Shaw, FE, Whitehead, A, Genc, Y, Vanoli, A, Martin, FC, Gosney, MA. Strategies to prevent falls and fractures in hospitals and care homes and effect of cognitive impairment: systematic review and meta-analyses. BMJ 2007; 334: 82.CrossRefGoogle ScholarPubMed
19Sherrington, C, Whitney, JC, Lord, SR, Herbert, RD, Cumming, RG, Close, JC. Effective exercise for the prevention of falls: a systematic review and meta-analysis. J Am Geriatr Soc 2008; 56: 2234–43.CrossRefGoogle Scholar
20Liu, CJ, Latham, NK. Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst Rev 2009; 3: CD002759.Google Scholar
21Close, J, Ellis, M, Hooper, R, Glucksman, E, Jackson, S, Swift, C. Prevention of falls in the elderly trial (PROFET): a randomised controlled trial. Lancet 1999; 353: 9397.CrossRefGoogle ScholarPubMed
22Campbell, AJ, Robertson, MC, Gardner, MM, Norton, RN, Buchner, DM. Falls prevention over 2 years: a randomized controlled trial in women 80 years and older. Age Ageing 1999; 28: 513–18.CrossRefGoogle Scholar
23Gardner, MM, Robertson, MC, Campbell, AJ. Exercise in preventing falls and fall related injuries in older people: a review of randomised controlled trials. Br J Sports Med 2000; 34: 717.CrossRefGoogle ScholarPubMed
24Gillespie, LD, Gillespie, WJ, Robertson, MC, Lamb, SE, Cumming, RG, Rowe, BH. Interventions for preventing falls in elderly people. Cochrane Database Syst Rev 2003; 4: CD000340.Google Scholar
25Province, MA, Hadley, EC, Hornbrook, MC, Lipsitz, LA, Miller, JP, Mulrow, CD, Ory, MG, Sattin, RW, Tinetti, ME, Wolf, SL. The effects of exercise on falls in elderly patients. A preplanned meta-analysis of the FICSIT Trials. Frailty and Injuries: Cooperative Studies of Intervention Techniques. JAMA 1995; 273: 1341–47.CrossRefGoogle ScholarPubMed
26Karinkanta, S, Heinonen, A, Sievanen, H, Uusi-Rasi, K, Pasanen, M, Ojala, K, Fogelholm, M, Kannus, P. A multi-component exercise regimen to prevent functional decline and bone fragility in home-dwelling elderly women: randomized, controlled trial. Osteoporos Int 2007; 18: 453–62.CrossRefGoogle ScholarPubMed
27Barnett, A, Smith, B, Lord, SR, Williams, M, Baumand, A. Community-based group exercise improves balance and reduces falls in at-risk older people: a randomised controlled trial. Age Ageing 2003; 32: 407–14.CrossRefGoogle ScholarPubMed
28Ballard, JE, McFarland, C, Wallace, LS, Holiday, DB, Roberson, G. The effect of 15 weeks of exercise on balance, leg strength, and reduction in falls in 40 women aged 65 to 89 years. J Am Med Womens Assoc 2004; 59: 255–61.Google ScholarPubMed
29Buchner, DM, Cress, ME, de Lateur, BJ, Esselman, PC, Margherita, AJ, Price, R, Wagner, EH. The effect of strength and endurance training on gait, balance, fall risk, and health services use in community-living older adults. J Gerontol A Biol Sci Med Sci 1997; 52: M21824.CrossRefGoogle ScholarPubMed
30Bunout, D, Barrera, G, Avendano, M, de la Maza, P, Gattas, V, Leiva, L, Hirsch, S. Results of a community-based weight-bearing resistance training programme for healthy Chilean elderly subjects. Age Ageing 2005; 34: 8083.CrossRefGoogle ScholarPubMed
31Carter, ND, Khan, KM, McKay, HA, Petit, MA, Waterman, C, Heinonen, A, Janssen, PA, Donaldson, MG, Mallinson, A, Riddell, L, Kruse, K, Prior, JC, Flicker, L. Community-based exercise program reduces risk factors for falls in 65- to 75-year-old women with osteoporosis: randomized controlled trial. CMAJ 2002; 167: 9971004.Google ScholarPubMed
32Korpelainen, R, Keinanen-Kiukaanniemi, S, Heikkinen, J, Vaananen, K, Korpelainen, J. Effect of impact exercise on bone mineral density in elderly women with low BMD: a population-based randomized controlled 30-month intervention. Osteoporos Int 2006; 17: 109–18.CrossRefGoogle Scholar
33Lord, SR, Castell, S, Corcoran, J, Dayhew, J, Matters, B, Shan, A, Williams, P. The effect of group exercise on physical functioning and falls in frail older people living in retirement villages: a randomized, controlled trial. J Am Geriatr Soc 2003; 51: 1685–92.CrossRefGoogle ScholarPubMed
34Lord, SR, Ward, JA, Williams, P, Strudwick, M. The effect of a 12-month exercise trial on balance, strength, and falls in older women: a randomized controlled trial. J Am Geriatr Soc 1995; 43: 1198–206.CrossRefGoogle ScholarPubMed
35Means, KM, Rodell, DE, O'Sullivan, PS. Balance, mobility, and falls among community-dwelling elderly persons: effects of a rehabilitation exercise program. Am J Phys Med Rehabil 2005; 84: 238–50.CrossRefGoogle ScholarPubMed
36Luukinen, H, Lehtola, S, Jokelainen, J, Vaananen-Sainio, R, Lotvonen, S, Koistinen, P. Pragmatic exercise-oriented prevention of falls among the elderly: a population-based, randomized, controlled trial. Prev Med 2007; 44: 265–71.CrossRefGoogle ScholarPubMed
37Rubenstein, LZ, Josephson, KR, Trueblood, PR, Loy, S, Harker, JO, Pietruszka, FM, Robbins, AS. Effects of a group exercise program on strength, mobility, and falls among fall-prone elderly men. J Gerontol A Biol Sci Med Sci 2000; 55: M31721.CrossRefGoogle ScholarPubMed
38Skelton, D, Dinan, S, Campbell, M, Rutherford, O. Tailored group exercise (Falls Management Exercise – FaME) reduces falls in community-dwelling older frequent fallers (an RCT). Age Ageing 2005; 34: 636–39.CrossRefGoogle ScholarPubMed
39Campbell, AJ, Robertson, MC, Gardner, MM, Norton, RN, Tilyard, MW, Buchner, DM. Randomised controlled trial of a general practice programme of home based exercise to prevent falls in elderly women. BMJ 1997; 315: 1065–69.CrossRefGoogle ScholarPubMed
40Weerdesteyn, V, Rijken, H, Geurts, AC, Smits-Engelsman, BC, Mulder, T, Duysens, J. A five-week exercise program can reduce falls and improve obstacle avoidance in the elderly. Gerontology 2006; 52: 131–41.CrossRefGoogle ScholarPubMed
41Lin, MR, Wolf, SL, Hwang, HF, Gong, SY, Chen, CY. A randomized, controlled trial of fall prevention programs and quality of life in older fallers. J Am Geriatr Soc 2007; 55: 499506.CrossRefGoogle ScholarPubMed
42Suzuki, T, Kim, H, Yoshida, H, Ishizaki, T. Randomized controlled trial of exercise intervention for the prevention of falls in community-dwelling elderly Japanese women. J Bone Miner Metab 2004; 22: 602–11.CrossRefGoogle ScholarPubMed
43Robertson, MC, Devlin, N, Scuffham, P, Gardner, MM, Buchner, DM, Campbell, AJ. Economic evaluation of a community based exercise programme to prevent falls. J Epidemiol Community Health 2001; 55: 600–6.CrossRefGoogle ScholarPubMed
44Li, F, Harmer, P, Fisher, KJ, McAuley, E, Chaumeton, N, Eckstrom, E, Wilson, NL. Tai Chi and fall reductions in older adults: a randomized controlled trial. J Gerontol A Biol Sci Med Sci 2005; 60:187–94.CrossRefGoogle ScholarPubMed
45Wolf, SL, Barnhart, HX, Kutner, NG, McNeely, E, Coogler, C, Xu, T. Reducing frailty and falls in older persons: an investigation of Tai Chi and computerized balance training. Atlanta FICSIT Group. Frailty and Injuries: Cooperative Studies of Intervention Techniques. J Am Geriatr Soc 1996; 44: 489–97.CrossRefGoogle ScholarPubMed
46Wolf, SL, Sattin, RW, Kutner, M, O'Grady, M, Greenspan, AI, Gregor, RJ. Intense tai chi exercise training and fall occurrences in older, transitionally frail adults: a randomized, controlled trial. J Am Geriatr Soc 2003; 51: 1693–701.CrossRefGoogle ScholarPubMed
47Cornillon, E, Blanchon, MA, Ramboatsisetraina, P, Braize, C, Beauchet, O, Dubost, V, Blanc, P, Gonthier, R. [Effectiveness of falls prevention strategies for elderly subjects who live in the community with performance assessment of physical activities (before–after)]. Ann Readapt Med Phys 2002; 45: 493504.CrossRefGoogle ScholarPubMed
48McMurdo, ME, Mole, PA, Paterson, CR. Controlled trial of weight bearing exercise in older women in relation to bone density and falls. BMJ 1997; 314: 569.CrossRefGoogle ScholarPubMed
49Liu-Ambrose, T, Khan, KM, Eng, JJ, Lord, SR, McKay, HA. Balance confidence improves with resistance or agility training. Increase is not correlated with objective changes in fall risk and physical abilities. Gerontology 2004; 50: 373–82.CrossRefGoogle Scholar
50Davis, JC, Robertson, MC, Ashe, MC, Liu-Ambrose, T, Khan, KM, Marra, CA. Does a home-based strength and balance programme in people aged > or = 80 years provide the best value for money to prevent falls? A systematic review of economic evaluations of falls prevention interventions. Br J Sports Med 2010; 44: 8089.CrossRefGoogle ScholarPubMed
51Frick, KD, Kung, JY, Parrish, JM, Narrett, MJ. Evaluating the cost-effectiveness of fall prevention programs that reduce fall-related hip fractures in older adults. J Am Geriatr Soc 2010; 58:136–41.CrossRefGoogle ScholarPubMed
52Wolf, SL, Barnhart, HX, Ellison, GL, Coogler, CE. The effect of Tai Chi Quan and computerized balance training on postural stability in older subjects. Atlanta FICSIT Group. Frailty and Injuries: Cooperative Studies on Intervention Techniques. Phys Ther 1997; 77: 371–81; discussion 82–84.CrossRefGoogle ScholarPubMed
53Voukelatos, A, Cumming, RG, Lord, SR, Rissel, C. A randomized, controlled trial of tai chi for the prevention of falls: the Central Sydney tai chi trial. J Am Geriatr Soc 2007; 55: 1185–91.CrossRefGoogle ScholarPubMed
54Clemson, L, Fiatarone Singh, MA, Bundy, A, Cumming, RG, Manollaras, K, O'Loughlin, P, Black, D. Integration of balance and strength training into daily life activity to reduce rate of falls in older people (the LiFE study): randomised parallel trial. BMJ 2012; 345: e4547.CrossRefGoogle ScholarPubMed
55Trombetti, A, Hars, M, Herrmann, FR, Kressig, RW, Ferrari, S, Rizzoli, R. Effect of music-based multitask training on gait, balance, and fall risk in elderly people: a randomized controlled trial. Arch Internal Med 2011; 171: 525–33.CrossRefGoogle ScholarPubMed
56Mulrow, CD, Gerety, MB, Kanten, D, Cornell, JE, DeNino, LA, Chiodo, L, Aguilar, C, O'Neil, MB, Rosenberg, J, Solis, RM. A randomized trial of physical rehabilitation for very frail nursing home residents. JAMA 1994; 271: 519–24.CrossRefGoogle ScholarPubMed
57Faber, MJ, Bosscher, RJ, Chin, APMJ, van Wieringen, PC. Effects of exercise programs on falls and mobility in frail and pre-frail older adults: A multicenter randomized controlled trial. Arch Phys Med Rehabil 2006; 87: 885–96.CrossRefGoogle ScholarPubMed
58Rosendahl, E, Gustafson, Y, Nordin, E, Lundin-Olsson, L, Nyberg, L. A randomized controlled trial of fall prevention by a high-intensity functional exercise program for older people living in residential care facilities. Aging Clin Exp Res 2008; 20: 6775.CrossRefGoogle ScholarPubMed
59Schoenfelder, DP. A fall prevention program for elderly individuals. Exercise in long-term care settings. J Gerontol Nurs 2000; 26: 4351.CrossRefGoogle ScholarPubMed
60Sakamoto, K, Nakamura, T, Hagino, H, Endo, N, Mori, S, Muto, Y, Harada, A, Nakano, T, Itoi, E, Yoshimura, M, Norimatsu, H, Yamamoto, H, Ochi, T. Effects of unipedal standing balance exercise on the prevention of falls and hip fracture among clinically defined high-risk elderly individuals: a randomized controlled trial. J Orthop Sci 2006; 11: 467–72.CrossRefGoogle ScholarPubMed
61Shimada, H, Obuchi, S, Furuna, T, Suzuki, T. New intervention program for preventing falls among frail elderly people: the effects of perturbed walking exercise using a bilateral separated treadmill. Am J Phys Med Rehabil 2004; 83: 493–99.CrossRefGoogle ScholarPubMed
62Sihvonen, S, Sipila, S, Taskinen, S, Era, P. Fall incidence in frail older women after individualized visual feedback-based balance training. Gerontology 2004; 50: 411–16.CrossRefGoogle ScholarPubMed
63Latham, NK, Anderson, CS, Lee, A, Bennett, DA, Moseley, A, Cameron, ID. A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS). J Am Geriatr Soc 2003; 51: 291–99.CrossRefGoogle ScholarPubMed
64Porthouse, J, Cockayne, S, King, C, Saxon, L, Steele, E, Aspray, T, Baverstock, M, Birks, Y, Dumville, J, Francis, R, Iglesias, C, Puffer, S, Sutcliffe, A, Watt, I, Torgerson, DJ. Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ 2005; 330: 1003.CrossRefGoogle ScholarPubMed
65Bischoff-Ferrari, HA, Orav, EJ, Dawson-Hughes, B. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch Intern Med 2006; 166: 424–30.Google ScholarPubMed
66Pfeifer, M, Begerow, B, Minne, HW, Abrams, C, Nachtigall, D, Hansen, C. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 2000; 15: 1113–18.CrossRefGoogle ScholarPubMed
67Gallagher, JC, Fowler, SE, Detter, JR, Sherman, SS. Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss. J Clin Endocrinol Metab 2001; 86: 3618–28.CrossRefGoogle ScholarPubMed
68Dhesi, JK, Jackson, SH, Bearne, LM, Moniz, C, Hurley, MV, Swift, CG, Allain, TJ. Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing 2004; 33: 589–95.CrossRefGoogle ScholarPubMed
69Sato, Y, Manabe, S, Kuno, H, Oizumi, K. Amelioration of osteopenia and hypovitaminosis D by 1alpha-hydroxyvitamin D3 in elderly patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 1999; 66: 6468.CrossRefGoogle ScholarPubMed
70Sato, Y, Kaji, M, Oizomi, K. An alternative to vitamin D supplementation to prevent fractures in patients with MS. Neurology 1999; 53: 437.CrossRefGoogle ScholarPubMed
71Pit, SW, Byles, JE, Henry, DA, Holt, L, Hansen, V, Bowman, DA. A Quality Use of Medicines program for general practitioners and older people: a cluster randomised controlled trial. Med J Aust 2007; 187: 2330.CrossRefGoogle ScholarPubMed
72Kenny, RA, Richardson, DA, Steen, N, Bexton, RS, Shaw, FE, Bond, J. Carotid sinus syndrome: a modifiable risk factor for nonaccidental falls in older adults (SAFE PACE). J Am Coll Cardiol 2001; 38: 1491–96.CrossRefGoogle ScholarPubMed
73Harwood, RH, Foss, AJ, Osborn, F, Gregson, RM, Zaman, A, Masud, T. Falls and health status in elderly women following first eye cataract surgery: a randomised controlled trial. Br J Ophthalmol 2005; 89: 5359.CrossRefGoogle ScholarPubMed
74Foss, AJ, Harwood, RH, Osborn, F, Gregson, RM, Zaman, A, Masud, T. Falls and health status in elderly women following second eye cataract surgery: a randomised controlled trial. Age Ageing 2006; 35: 6671.CrossRefGoogle ScholarPubMed
75Stevens, M, Holman, CD, Bennett, N. Preventing falls in older people: impact of an intervention to reduce environmental hazards in the home. J Am Geriatr Soc 2001; 49: 1442–47.CrossRefGoogle ScholarPubMed
76Pighills, AC, Torgerson, DJ, Sheldon, TA, Drummond, AE, Bland, JM. Environmental assessment and modification to prevent falls in older people. J Am Geriatr Soc 2011; 59: 2633.CrossRefGoogle ScholarPubMed
77Cumming, RG, Ivers, R, Clemson, L, Cullen, J, Hayes, MF, Tanzer, M, Mitchell, P. Improving vision to prevent falls in frail older people: a randomized trial. J Am Geriatr Soc 2007; 55: 175–81.CrossRefGoogle ScholarPubMed
78Campbell, AJ, Robertson, MC, La Grow, SJ, Kerse, NM, Sanderson, GF, Jacobs, RJ, Sharp, DM, Hale, LA. Randomised controlled trial of prevention of falls in people aged > or = 75 with severe visual impairment: the VIP trial. BMJ 2005; 331: 817.CrossRefGoogle ScholarPubMed
79Cumming, RG, Thomas, M, Szonyi, G, Salkeld, G, O'Neill, E, Westbury, C, Frampton, G. Home visits by an occupational therapist for assessment and modification of environmental hazards: a randomized trial of falls prevention. J Am Geriatr Soc 1999; 47: 1397–402.CrossRefGoogle ScholarPubMed
80Day, L, Fildes, B, Gordon, I, Fitzharris, M, Flamer, H, Lord, S. Randomised factorial trial of falls prevention among older people living in their own homes. BMJ 2002; 325: 128.CrossRefGoogle ScholarPubMed
81Menant, JC, Steele, JR, Menz, HB, Munro, BJ, Lord, SR. Optimizing footwear for older people at risk of falls. J Rehabil Res Dev 2008; 45: 1167–81.CrossRefGoogle ScholarPubMed
82McKiernan, FE. A simple gait-stabilizing device reduces outdoor falls and nonserious injurious falls in fall-prone older people during the winter. J Am Geriatr Soc 2005; 53: 943–47.CrossRefGoogle ScholarPubMed
83Spink, MJ, Menz, HB, Fotoohabadi, MR, Wee, E, Landorf, KB, Hill, KD, Lord, SR. Effectiveness of a multifaceted podiatry intervention to prevent falls in community dwelling older people with disabling foot pain: randomised controlled trial. BMJ 2011; 342: 3411.CrossRefGoogle ScholarPubMed
84Hill, S, Mossman, J, Stockdale, P, Crome, P. A randomised controlled trial of a nurse-led falls prevention clinic. Age Ageing 2000; 29 (suppl 2): 20.Google Scholar
85Clemson, L, Cumming, RG, Kendig, H, Swann, M, Heard, R, Taylor, K. The effectiveness of a community-based program for reducing the incidence of falls in the elderly: a randomized trial. J Am Geriatr Soc 2004; 52: 1487–94.CrossRefGoogle ScholarPubMed
86Shumway-Cook, A, Silver, IF, LeMier, M, York, S, Cummings, P, Koepsell, TD. Effectiveness of a community-based multifactorial intervention on falls and fall risk factors in community-living older adults: a randomized, controlled trial. J Gerontol A Biol Sci Med Sci 2007; 62: 1420–27.CrossRefGoogle ScholarPubMed
87Swanenburg, J, de Bruin, ED, Stauffacher, M, Mulder, T, Uebelhart, D. Effects of exercise and nutrition on postural balance and risk of falling in elderly people with decreased bone mineral density: randomized controlled trial pilot study. Clin Rehabil 2007; 21: 523–34.CrossRefGoogle ScholarPubMed
88Assantachai, P, Chatthanawaree, W, Thamlikitkul, V, Praditsuwan, R, Pisalsarakij, D. Strategy to prevent falls in the Thai elderly: a controlled study integrated health research program for the Thai elderly. J Med Assoc Thai 2002; 85: 215–22.Google ScholarPubMed
89Davison, J, Bond, J, Dawson, P, Steen, IN, Kenny, RA. Patients with recurrent falls attending Accident & Emergency benefit from multifactorial intervention–a randomised controlled trial. Age Ageing 2005; 34: 162–68.CrossRefGoogle ScholarPubMed
90Hornbrook, MC, Stevens, VJ, Wingfield, DJ, Hollis, JF, Greenlick, MR, Ory, MG. Preventing falls among community-dwelling older persons: results from a randomized trial. Gerontologist 1994; 34: 1623.CrossRefGoogle ScholarPubMed
91Lord, SR, Tiedemann, A, Chapman, K, Munro, B, Murray, SM, Gerontology, M, Ther, GR, Sherrington, C. The effect of an individualized fall prevention program on fall risk and falls in older people: a randomized, controlled trial. J Am Geriatr Soc 2005; 53: 1296–304.CrossRefGoogle ScholarPubMed
92Tinetti, ME, Baker, DI, McAvay, G, Claus, EB, Garrett, P, Gottschalk, M, Koch, ML, Trainor, K, Horwitz, RI. A multifactorial intervention to reduce the risk of falling among elderly people living in the community. N Engl J Med 1994; 331: 821–27.CrossRefGoogle ScholarPubMed
93Salminen, MJ, Vahlberg, TJ, Salonoja, MT, Aarnio, PT, Kivelä, S-L. Falls data (as supplied 20 May 2008) – unpublished data. Data on file. 2008.Google Scholar
94Wyman, J, Gross, C, DiFabio, R, Nyman, J, Lindquist, R, McCarthy, T. A randomized trial of exercise, education, and risk reduction counseling to prevent falls in populationbased sample of older women. Gerontologist 2005; 45 (Special Issue II): 297.Google Scholar
95Carpenter, GI, Demopoulos, GR. Screening the elderly in the community: controlled trial of dependency surveillance using a questionnaire administered by volunteers. BMJ 1990; 300: 1253–56.CrossRefGoogle ScholarPubMed
96Gallagher, EM, Brunt, H. Head over heels: impact of a health promotion program to reduce falls in the elderly. Canadian J Aging 1996; 15: 8496.CrossRefGoogle Scholar
97Hogan, DB, MacDonald, FA, Betts, J, Bricker, S, Ebly, EM, Delarue, B, Fung, TS, Harbidge, C, Hunter, M, Maxwell, CJ, Metcalf, B. A randomized controlled trial of a community-based consultation service to prevent falls. CMAJ 2001; 165: 537–43.Google ScholarPubMed
98Lightbody, E, Watkins, C, Leathley, M, Sharma, A, Lye, M. Evaluation of a nurse-led falls prevention programme versus usual care: a randomized controlled trial. Age Ageing 2002; 31: 203–10.CrossRefGoogle ScholarPubMed
99Mahoney, JE, Shea, TA, Przybelski, R, Jaros, L, Gangnon, R, Cech, S, Schwalbe, A. Kenosha County falls prevention study: a randomized, controlled trial of an intermediate-intensity, community-based multifactorial falls intervention. J Am Geriatr Soc 2007; 55: 489–98.CrossRefGoogle ScholarPubMed
100Rubenstein, LZ, Alessi, CA, Josephson, KR, Trinidad Hoyl, M, Harker, JO, Pietruszka, FM. A randomized trial of a screening, case finding, and referral system for older veterans in primary care. J Am Geriatr Soc 2007; 55: 166–74.CrossRefGoogle ScholarPubMed
101Elley, CR, Robertson, MC, Garrett, S, Kerse, NM, McKinlay, E, Lawton, B, Moriarty, H, Moyes, SA, Campbell, AJ. Effectiveness of a falls-and-fracture nurse coordinator to reduce falls: a randomized, controlled trial of at-risk older adults. J Am Geriatr Soc 2008; 56: 1383–89.CrossRefGoogle Scholar
Figure 0

Figure 1. Estimated number of hip fractures in four geographic regions in 1990 and 20503

Figure 1

Figure 2. Comparison of number of falls in community-living older people exposed to intervention with different types of exercise versus controls reported in several randomized controlled trials (RCTs)

Figure 2

Figure 3. Comparison of number of falls in older people living in nursing home or hospitals exposed to intervention with different types of exercise versus controls reported in several RCTs

Figure 3

Figure 4. Comparison of number of falls in community-living older people exposed to vitamin D supplement with or without calcium versus controls reported in several RCTs

Figure 4

Figure 5. Comparison of number of falls in community-living older people exposed to drug withdrawal, surgery and foot assessment versus controls reported in several RCTs

Figure 5

Figure 6. Comparison of number of falls in community-living older people exposed to intervention with home hazard assessment followed by risk factor reduction versus controls reported in several RCTs

Figure 6

Figure 7. Comparison of number of falls in community-living older people exposed to generalized multifaceted interventions versus controls reported in several RCTs

Figure 7

Figure 8. Comparison of number of falls in community-living older people exposed to individualized multifactorial interventions versus controls reported in several RCTs