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Prevention and treatment of venous thromboembolism in the elderly

Published online by Cambridge University Press:  17 November 2008

HGM Shetty*
Affiliation:
University of Wales College of Medicine, Cardiff, UK
PA Routledge
Affiliation:
University of Wales College of Medicine, Cardiff, UK
*
HGM Shetty, B6 Stem, University Hospital of Wales, Heath Park, Cardiff, South Glamorgan CF4 4XN, UK.

Abstract

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Type
Clinical geriatrics
Copyright
Copyright © Cambridge University Press 1996

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References

1Kniffin, WD Jr, Baron, JA, Barrett, J et al. The epidemiology of diagnosed pulmonary embolism and deep venous thrombosis in the elderly. Arch Intern Med 1994; 154: 861–66.CrossRefGoogle ScholarPubMed
2Mangion, DM. Pulmonary embolism – incidence and prognosis in hospitalised elderly. Postgrad Med J 1989; 65: 814–17.CrossRefGoogle Scholar
3Sandler, DA, Martin, JF. Autopsy proven pulmonary embolism in hospital patients: are we detecting enough deep vein thrombosis? J R Soc Med 1989; 82: 203205.CrossRefGoogle ScholarPubMed
4Fratantoni, J, Wessier, S. Prophylactic therapy of deep vein thrombosis and pulmonary embolism. DHEW publ. no. (NIH) 76–866. Washington, DC: US Government Printing Office, 1975.Google Scholar
5Thromboembolic Risk Factors (THRIFT) Consensus Group. Risk of and prophylaxis for venous thromboembolism in hospital patients. BMJ. 1992; 305: 567–74.CrossRefGoogle Scholar
6Hull, RD, Kakkar, VV, Raskob, GE. Prevention of venous thrombosis and pulmonary embolism. In: Fuster, V, Verstraete, M eds. Thrombosis in cardiovascular disorders. Philadelphia: WB Saunders Company, 1992: 451–64.Google Scholar
7Clagett, GP, Reisch, JS. Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis. Ann Surg 1988; 208: 227–40.CrossRefGoogle ScholarPubMed
8Collins, R, Scrimgeour, A, Yusef, S, Peto, R. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin. N Engl J Med 1988; 318: 1162–73.CrossRefGoogle ScholarPubMed
9International Multicentre Trial. Prevention of fatal post-operative pulmonary embolism by low doses of heparin. Lancet 1975; ii: 4551.Google Scholar
10Leyvraz, PF, Richard, J, Bachmann, F et al. Adjusted versus fixed dose subcutaneous heparin in the prevention of deep vein thrombosis after total hip replacement. N Engl J Med 1983; 309: 954–58.CrossRefGoogle ScholarPubMed
11Hirsh, J, Levine, MN. Low molecular weight heparin. Blood 1992; 79: 117.CrossRefGoogle ScholarPubMed
12Kakkar, W, Cohen, AT, Edmonson, RA et al. Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery. Lancet 1993; 341: 259–65.CrossRefGoogle ScholarPubMed
13Green, D, Hirsh, J, Keit, J et al. Low molecular weight heparin: a critical analysis of clinical trials. Pharmacol Rev 1994; 46: 89109.Google ScholarPubMed
14Warlow, C, Ogston, D, Douglas, A. Venous thrombosis following stroke. Lancet 1972; i: 1305–306.CrossRefGoogle Scholar
15Turpie, AGG, Gent, M, Côte, R et al. A low molecular weight heparinoid compared with infractionated heparin in the prevention of deep vein thrombosis in patients with acute stroke. A randomized, double-blind study. Ann Intern Med 1992; 117: 353–57.CrossRefGoogle Scholar
16Eriksson, BI, Edman, S, Kälebo, P et al. Prevention of deep vein thrombosis after total hip replacement: direct thrombin inhibition with recombinant hirudin, CGP 39393. Lancet 1996; 347: 635–39.CrossRefGoogle ScholarPubMed
17Pini, M, Pattacinic, , Quintavalla, R et al. Subcutaneous vs intravenous heparin in the treatment of deep venous thrombosis – a randomized clinical trial. Thromb Haemost 1990; 64: 222–26.Google ScholarPubMed
18Fennerty, A, Campbell, IA, Routledge, PA. Anticoagulants in venous thromboembolism. BMJ 1988; 297: 1285–88.CrossRefGoogle ScholarPubMed
19Lensing, AWA, Prins, MJ, Davidson, BL, Hirsh, J. Treatment of deep venous thrombosis with low molecular weight heparins. A meta-anlaysis. Arch Intern Med 1995; 155: 601607.CrossRefGoogle Scholar
20Hull, RD, Raskob, GE, Rosenblomm, D et al. Heparin for 5 days as compared with 10 days in the initial treatment of proximal venous thrombosis. N Engl J Med 1990; 322 1260–64.CrossRefGoogle ScholarPubMed
21Shetty, HGM, Routledge, PA. Computer assisted anticoagulation. In: Fuster, V, Verstraete, M eds. Thrombosis in cardiovascular disorders. Philadelphia: WB Saunders, 1992: 523–27.Google Scholar
22British Society for Haematology. British Committee for Standards in Haematology. Haemostasis and Thrombosis Task Force. Guidelines on oral anticoagulation: second edition, J Clin Pathol 1990; 43: 177–83.CrossRefGoogle Scholar
23Shetty, HGM, Backhouse, G, Bentley, DP et al. Effective reversal of warfarin-induced excessive anticoagulation with low dose vitamin K1. Thromb Haemost 1992; 67: 1315.Google ScholarPubMed
24Research Committee of the British Thoracic Society. Optimum duration of anticoagulation for deep vein thrombosis and pulmonary embolism. Lancet 1992; 340: 873–76.CrossRefGoogle Scholar
25Schulman, S, Rhedin, A, Lindmarker, P et al. A comparison of six weeks with six months of oral anticoagulant therapy after first episode of venous thromboembolism. N Engl J Med 1995; 332: 1661–65.CrossRefGoogle ScholarPubMed
26Verstraete, M, Verhaeghe, R, Routledge, PA. Anticoagulants in the elderly. In: Butchart, EG, Bodnar, E eds. Thrombosis, embolism and bleeding. London: ICR Publishers, 1992: 356–61.Google Scholar
27Routledge, PA, Chapman, PH, Davies, DM, Rawlins, MD. Factors affecting warfarin requirements – a prospective population study. Ear J Clin Pharmacol 1979; 15: 319–22.CrossRefGoogle ScholarPubMed
28Terrin, M, Goldhaber, SZ, Thompson B and the TIPE investigators. Selection of patients with acute pulmonary embolism for thrombolytic therapy. Thrombolysis in pulmonary embolism (TIPE) patient survey. Chest 1989; 95: 2795–815.Google ScholarPubMed
29Rogers, LQ, Lutcher, CL. Streptokinase therapy for deep vein thrombosis: a comprehensive review of the English literature. Am J Med 1990; 88: 389–95.CrossRefGoogle ScholarPubMed
30Stein, PD, Hull, RD, Raskob, G. Risks for major bleeding from thrombolytic therapy in patients with acute pulmonary embolism. Consideration of non-invasive management. Ann Intern Med 1994; 121: 313–17.CrossRefGoogle Scholar
31Clarke, DB, Abrams, LD. Pulmonary embolectomy: a 25-year experience. J Thorac Cardiovasc Surg 1986; 92: 442–45.CrossRefGoogle ScholarPubMed
32Meyer, G, Tamisier, D, Sors, H et al. Pulmonary embolectomy: a 20-year experience in one center. Ann Thorac Surg 1991; 51: 232–36.CrossRefGoogle ScholarPubMed
33Moser, KJ, Auger, WR, Fedullo, PF. Chronic major-vessel thrombo-embolic pulmonary hypertension. Circulation 1990; 81: 1735–43.CrossRefGoogle Scholar
34Levine, M, Gent, M, Hirsh, J et al. A comparison of low molecular weight heparin administered primarily at home with unfractionated heparin administered in hospital for proximal deep vein thrombosis. N Engl J Med 1996; 334: 677–81.CrossRefGoogle ScholarPubMed